Biomedical subjects

D B Flach

Publications and source records attributed to D B Flach.

3 recordsLinked to original sources

PubMed1988

Lung cancer and scleroderma.

Among 14 patients with carcinoma of the lung and scleroderma, 9 had no history of smoking. The 14 cases of primary lung carcinoma occurred in a population of 3550 patients with a diagnosis of scleroderma. Scleroderma preceded the diagnosis of lung cancer by at least 6 years in 8 cases. Scleroderma and lung carcinoma were diagnosed within 3 years of each other in 4 cases. The most frequent type of carcinoma in our series was small cell carcinoma, which accounted for 5 of the 14 cases. Our data indicate an increased risk of carcinoma of the lung in patients with scleroderma, even among nonsmokers. Small cell carcinoma of the lung is probably much more common in patients with scleroderma in whom lung carcinoma develops than is indicated by previous reports.

Adolescent↗

PubMed1986

Juvenile xanthogranuloma with central nervous system lesions.

We describe two boys in whom extensive normolipemic cutaneous papulonodular xanthomatous lesions developed and disabling central nervous system disease later developed. Histologically, lesional skin from each patient was consistent with juvenile xanthogranuloma. Electron microscopic studies in each case failed to reveal Langerhans (Birbeck) granules. Results of S-100 protein studies done with the peroxidase-immunoperoxidase technic were negative in each case. Radiation therapy and systemic corticosteroids have been partially successful in controlling the cerebellar ataxia experienced by one of the patients. The other patient had progressive central nervous system disease and died 8 years after the onset of his skin lesions despite radiation therapy and systemic chemotherapy. We believe that these cases are examples of normolipemic, xanthomatous, non-X histiocytosis with features of juvenile xanthogranuloma and aggressive central nervous system disease.

Brain Diseases↗

PubMed1985

Neutrophilic dermatoses and myeloproliferative disease: report of two cases.

The term "neutrophilic dermatosis" has been suggested for a spectrum of skin lesions that have been noted in some patients with myeloproliferative diseases. These cutaneous conditions vary from plaques typical of Sweet's syndrome to bullous and pyodermatous lesions. We describe two patients with neutrophilic dermatoses and myeloproliferative disorders. Distinctive features included concurrent bullous pyodermatous lesions and characteristic lesions of Sweet's syndrome in one patient and overwhelming sterile pulmonary infiltration in the other patient. These disorders may be difficult to distinguish from acute infectious processes, and they may have systemic components, including pneumonitis. Possible therapeutic alternatives to systemic corticosteroid therapy are suggested.

Aged↗