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Biomedical subjects

D B Gould

Publications and source records attributed to D B Gould.

At least 19 recordsLinked to original sources
PubMed1996

Venous air embolism retrieval catheters cannot capture bubbles; an air lock is required.

Differently designed right atrial venous air embolism retrieval catheters were tested in vitro in clinical simulations to determine if increasing numbers of aspirating orifices enhance the recovery of air bubbles by aspirating through these catheters. Air bubbles of 1.5 to 2.0 mm diameter were directly observed to pass against the aspirating orifices while catheters were vertically suspended in a 3.7 cm diameter glass cylinder filled with hetastarch. Essentially, no air, only fluid, was recovered by any of these submerged catheters upon aspiration. Only when an orifice was positioned above a fluid level could air be retrieved.

Cardiac Catheterization↗
PubMed1996

Autosomal dominant iridogoniodysgenesis anomaly maps to 6p25.

Autosomal dominant iridogoniodysgenesis anomaly (IGDA) is characterized by iris hypoplasia and goniodysgenesis with frequent juvenile glaucoma. IGDA is the result of aberrant migration or terminal induction of the neural crest cells involved in the formation of the anterior chamber of the eye. After eliminating candidate regions for other ocular disorders, a genome-wide scan for IGDA was performed using linkage analysis. Approximately 95% of the genome was excluded with >300 microsatellite markers before significant linkage was demonstrated between IGDA and chromosome 6 markers in two families. From haplotype analysis and identification of recombinants, the IGDA locus is mapped to an 8.3-cM interval distal to D6S477, at 6p25. Our linkage results are consistent with the ocular findings in rare cases of individuals with chromosomal anomalies involving deletions of 6p. This suggests that there is a major gene involved in eye anterior segment development at 6p25.

Chromosome Mapping↗
PubMed1994

Internal carotid artery dissection after remote surgery. Iatrogenic complications of anesthesia.

BACKGROUND: Subintimal dissection with acute occlusion of the internal carotid artery resulting in acute cerebral infarction has not been reported as an iatrogenic complication of general anesthesia. CASE DESCRIPTIONS: An anesthetist stretched the neck of a 44-year-old man by anchoring an anesthesia mask posterior to the angle of the jaw with overlying fingers as the patient struggled during an insufficient inhalational mask anesthetic. A 33-year-old man received an endotracheal anesthetic without struggle, but as he was turned from a supine to a prone position, his head and neck were not immobilized to rotate with his torso during the move. The next day both patients suffered acute cerebral infarctions secondary to ICA dissections and occlusions (angiographically demonstrated). CONCLUSIONS: Stretching the soft neck tissues of anesthetized patients can cause internal carotid artery dissection and acute cerebral infarction.

Adult↗
PubMed1983

Bupivacaine cardiotoxicity in a patient with renal failure.

Bradycardia and hypotension were the first major signs of toxicity from a 250 mg bupivacaine axillary brachial plexus block experienced by a patient with chronic renal failure, who had an anion gap acidosis and hyperkalaemia. Without these metabolic abnormalities, this patient received four similar blocks: three were without incident and one was complicated by seizure. Acidosis and/or hyperkalaemia in man appears to increase the myocardial susceptibility to bupivacaine toxicity into the range of arterial concentrations of the drug normally produced by plexus blocks, even in the absence of drug-induced cerebral toxicity, seizures and hypoxia.

Acidosis↗
PubMed1982

Effect of nitrous oxide solubility on vaporizer aberrance.

Concentrations of halogenated anesthetics produced by contemporary vaporizers vary from vaporizer dial settings when carrier gas is not 100% oxygen. This effect is most marked when carrier gas changes from 100% O2 to 100% nitrous oxide (N2O). Vapor concentrations of halothane and enflurane from vaporizers with 6 L/min carrier gas flows were reduced to 3% from 4% until absorption of N20 by the liquid anesthetic ceased. Presaturation of liquid anesthetics with N2O eliminated the transient decrease of vapor output. Steady-state outputs of halothane and enflurane in 100% N2O were 10% below dial settings. The significance of these changes in administration of closed-circuit anesthesia with an out-of-circuit vaporizer is discussed.

Anesthesiology↗