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Biomedical subjects

D B Hom

Publications and source records attributed to D B Hom.

27 records · Page 2Linked to original sources
PubMed1993

Endothelial cell growth factor (ECGF) application to irradiated soft tissue.

Delayed postoperative wound healing in previously radiated cancer patients is a common and debilitating occurrence. Prior studies have given evidence that endothelial cell growth factor (ECGF) can accelerate neovascularization in soft tissue. To explore its effects in irradiated tissue, an ECGF-heparin formulation (7200 micrograms/mL) contained in Gelfoam was applied to previously irradiated (N = 38) and nonirradiated skin flaps (N = 38) on rabbit ears. Both peripheral neovascularization and flap viability were quantitatively documented by polar planimetry and digital angiography in all flaps. The ECGF-heparin flaps had a greater than twofold increase in both vascularity and viability when compared to their controls among the irradiated and nonirradiated flaps (P < .01). Also, the additional viability and vascularization effects from ECGF-heparin did not appear statistically altered by previous radiation. These results support the promising angiogenic effect of ECGF-heparin in previously irradiated surgical wounds.

Animals↗
PubMed1993

A practical methodology to analyze facial deformities.

Despite much information about various methods to analyze the face, a practical stepwise methodology has not been firmly established in otolaryngology teaching programs. A general guideline for facial analysis would be helpful to individuals not totally familiar with facial analysis for assessing facial deformities resulting from to traumatic, neoplastic, or developmental causes. This article attempts to distill and integrate previously established guidelines for facial analysis into eight major steps to provide a preliminary and practical methodology for initial facial assessment.

Algorithms↗
PubMed1992

Effects of endothelial cell growth factor on vascular compromised skin flaps.

Angiogenic growth factors have the potential to accelerate vascularization in soft tissue. This study explored the vascular effects of endothelial cell growth factor (1800 micrograms/mL) with heparin (7 micrograms/mL) in gelatin sponge (Gelfoam) in two settings of vascular compromise. On days 2 and 3 ligated skin flaps in the rabbit ear model, peripheral neovascularization, and flap viability were quantitatively documented by digital angiographic analysis and by polar planimetry. The mean flap viability of the treated flaps was two times greater than their controls in the day 2 (N = 24) and day 3 ligation groups (N = 22). The angiograms among the treated flaps in the day 2 ligation group also demonstrated a quantitative increase in vascularization compared with their controls. These results suggest a provocative means for accelerating neovascularization and enhancing viability to vascular compromised skin flaps.

Administration, Topical↗
PubMed1992

Angiogenic growth factors: their effects and potential in soft tissue wound healing.

Since their discovery 30 years ago, angiogenic growth factors have been demonstrated to stimulate neovascularization in vitro and in animal studies. Over the last decade, knowledge gained in the field of angiogenic growth factors has grown immensely. These angiogenic growth factors exist in four major families: fibroblast growth factor (FGF), transforming growth factor beta (TGF-beta), platelet-derived growth factor (PDGF), and epidermal growth factor (EGF). Each has the ability to induce soft tissue vascularization in microgram quantities. In animal models, FGF, TGF-beta, PDGF, and EGF have been shown to enhance soft tissue wound healing. In human clinical trials, EGF, and a mixture of PDGFs have been demonstrated to accelerate epidermal regeneration in cutaneous wounds. These factors have considerable therapeutic potential in the areas of soft tissue wound healing and otolaryngology. This article reviews important aspects of angiogenic growth factors and discusses their future potential in soft tissue wound healing.

Animals↗
PubMed1990

Augmentation mentoplasty using Mersilene mesh.

Many different materials are available for augmentation mentoplasty. However, the optimal implant material for chin implantation has yet to be found. During the past several years, a number of experienced surgeons have turned to the use of Mersilene mesh. Mersilene mesh is a non-absorbable Dacron polyester fiber that can be conformed easily into layers to achieve tailored dimensions and shape. At the McCollough Plastic Surgery Clinic PA, Birmingham, Ala, 277 patients over a 10-year period underwent chin augmentation with Mersilene mesh implants. The material provides excellent tensile strength, durability, and surgical adaptability. The overall complication rate was 3.2% (nine patients); infection rate, 2.5% (seven patients); and removal secondary to infection, 1.7% (five patients). Based on this 10-year experience, Mersilene mesh remains our material of choice for chin augmentation.

Adult↗
PubMed1988

Utilizing angiogenic agents to expedite the neovascularization process in skin flaps.

The revascularization of a skin flap after flap transposition is an important step in flap survival. This study investigates the efficacy of certain angiogenic agents to expedite the neovascularization process and to increase the viability of skin flaps. Eighty-four island skin flaps were designed on the auricles of 42 New Zealand White rabbits to achieve 90% necrosis over a 7-day period. Thirty-six flaps were treated with Endothelial Cell Growth Supplement (ECGS) or Endothelial Cell Growth Factor (ECGF) at several concentrations topically or immersed in Gelfoam. The remaining flaps were used as normal saline controls. Flap viability and peripheral neovascularization were documented by polar planimetry, angiography, and histological analysis. The flap viability of the ECGS-Gelfoam -treated flaps was 100% greater than their normal saline-Gelfoam controls (p = .021). Flap angiograms demonstrated increased vascular ingrowth among the treated flaps compared to the controls. This study suggests that angiogenic agents can expedite flap neovascularization and have the potential to increase flap viability.

Administration, Topical↗
PubMed1987

An unusual complication of tracheostomy.

Synthetic pediatric tracheostomy tubes have been a major advance for both short- and long-term airway support. We present a late complication from the use of a Shiley silicone pediatric tracheostomy tube (Silastic), and its radiologic manifestations. To our knowledge, this complication has not been previously reported.

Child, Preschool↗
PubMedDate not supplied

A new era of discovery in facial plastic surgery.

OBJECTIVE: To review recent advances in our understanding of molecular biology and wound healing relevant to facial plastic surgery. DATA SOURCES: Recent basic science literature relevant to molecular biology and wound healing and its clinical implications. CONCLUSIONS: During the 21st century, we will experience a new biological and informational age that will have profound implications for facial plastic surgery. This modern era will be driven by discoveries in molecular biology and wound healing that will result in new diagnosis and treatment modalities.

Craniofacial Abnormalities↗