Biomedical subjects

D B Osbon

Publications and source records attributed to D B Osbon.

At least 19 recordsLinked to original sources

PubMed1985

Delayed mandibular reconstruction following removal of a mesenchymal chondrosarcoma. Report of a case.

An unusual case of mesenchymal chondrosarcoma is presented. Initially seen when the patient was 8 years old, the lesion was repeatedly biopsied and curetted with a diagnosis of odontogenic fibroma. In 1971 a diagnosis of osteosarcoma of the chondroblastic type was made. At that time, the patient underwent a partial mandibulectomy with immediate graft. The patient did well until 1981, when a recurrence of the lesion was noted. The microscopic diagnosis at this time was mesenchymal chondrosarcoma. The treatment of this lesion as a staged procedure with initial resection of the mandible and placement of a silicone rubber mandibular prosthesis is discussed. The second stage of the procedure was definitive mandibular reconstruction, with an allogeneic mandible as a crib for autologous particulate cancellous bone from the iliac crest. Although the prognosis of mesenchymal chondrosarcoma is usually grave, this case is unusual because of its long history of multiple procedures performed prior to the definitive treatment of the lesion 14 years after its discovery. Two-year follow-up since the definitive mandibular reconstruction shows adequate range of motion, excellent healing, and no recurrence.

Bone Transplantation↗

PubMed1983

Influence of polylactic acid mesh on the incidence of localized osteitis.

A biodegradable polylactic acid surgical implant, designed to facilitate dental extraction wound heading, is described. Animal studies have proved the safety and tissue compatibility of the implanted polylactic acid material. A clinical study using this material in mandibular third molar extraction sites in human subjects is reviewed. Results of that study reveal the implant to be effective in reducing the incidence of localized osteitis following mandibular third molar extractions.

Adolescent↗

PubMed1983

Arteriovenous malformations of the mandible.

Arteriovenous malformations of the mandible may present with pulsatile tinnitus, pain, a bruit, loosening of teeth, or intraoral or facial deformation or discoloration. In the absence of these classic symptoms and signs, the unwary surgeon might attempt a limited excision, leading to massive intraoperative hemorrhage. Management includes external carotid as well as selective branch arteriography and preoperative arterial embolization with polyvinyl alcohol sponges and absorbable gelatin. Vessel ligation, mandibular resection, lesion excision, mandibular autografting, and intermaxillary fixation complete surgical treatment.

Adult↗

PubMed1982

A comparative study of polylactic acid, Gelfoam, and Surgicel in healing extraction sites.

The search for a biodegradable material which may be placed in a fresh extraction socket to facilitate healing and prevent localized osteitis is a project which continues to hold much interest for oral surgeons. Polylactic acid is a biodegradable material which appears to have some promise in this area. The present study was devised to compare polylactic acid with two commonly used biodegradable substances and natural healing in order to determine the tissue response and suitability of polylactic acid as a treatment modality in fresh extraction sites. The over-all results were very satisfactory. The polylactic acid was well tolerated and did not interfere with the healing process.

Alveolar Process↗

PubMed1982

A retrospective study of alveolar cleft grafting.

A surgical technique for the bone graft repair of alveolar clefts is described, and an evaluation of the conditions of 30 patients who have undergone that procedure is reported. Evaluation was made specifically for the preoperative and postoperative presence of oronasal fistula, postoperative eruption of previously unerupted teeth into the graft, soft and hard tissue periodontal status, and radiographic evidence of bone fill in the previous cleft defect resulting in alveolar segmental stabilization.

Adolescent↗

PubMed1982

Fractures of the mandible: a review of 580 cases.

The anatomic distribution of fractures in this study showed more fractures of the condylar and parasymphysis/symphysis regions, with correspondingly fewer body and angle fractures, than in other reported studies. The site of fracture is related to the type of trauma involved. Altercations, in which most force is directed in a single blow to the lateral aspect of the jaw, tend to result more frequently in angle and body fractures and less often in condylar, symphysis, and alveolar fractures. Automobile accidents, which more frequently involve trauma to the anterior mandible, result in more fractures of the symphysis region, alveolus and condyle. Motorcycle accidents produce many more alveolar fractures, suggesting that the traumatic force in this kind of accident is often directed to the alveolus. As might be expected, those individuals involved in motor vehicle accidents had the highest incidence of other injuries in addition to the mandibular fractures. Injuries to the head and neck were most common, but a wide variety of other injuries occurred. Complications are more common in the patient who has sustained multiple trauma. Most fractures were treated by closed reduction. When open reduction was necessary, the most common sites were the angle, body, and symphysis regions.

Adolescent↗

PubMed1980

Hypothalamic-pituitary-adrenal suppression after short-term dexamethasone therapy for oral surgical procedures.

Ten patients were given dexamethasone therapy for prevention of postoperative complications after oral surgical procedures. The hypothalamic-pituitary-adrenal response of the patients was measured by their response to a single-dose metyrapone test. A significant difference was found between preoperative values of 11-deoxycortisol and values three days postoperatively. No difference was found when comparing preoperative values of 11-deoxycortisol with values seven days postoperatively. There appears to be an initial suppression of the normal feedback mechanism of the hypothalamic-pituitary-adrenal axis followed by a complete return of normal functioning by the seventh postoperative day. The amount of surgical stress involved in these routine oral surgical procedures is of an insufficient magnitude to overcome this hypothalamic-pituitary-adrenal suppression of the negative feedback mechanism caused by dexamethasone therapy. The presence of adequate amounts of synthetic steroids at a cellular level appears to prevent manifestations of adrenal insufficiency despite suppression of endogenous production of steroids.

Adult↗

PubMed1978

Leukemia: the dentist's role in diagnosis.

Patients with leukemia frequently have oral signs and symptoms that may lead to the early diagnosis of this condition. Hematologic laboratory tests that would be of value include a white blood cell count and a platelet count. The dental practitioner should be aware of those diagnostic signs and the possibilities of oral complications associated with the disease. The nature of leukemia and its complications require a regular and thorough oral examination as part of the routine treatment of these patients.

Adult↗

PubMed1977

Bone grafts with surface decalcified allogeneic and particulate autologous bone: report of cases.

A method for mandibular bone grafting that uses a combination of SDAB and particulate autologous cancellous bone and marrow is presented. The results of this treatment in four patients are described. Two additional maxillary bone grafts that use only SDAB are also reported. Grafts that are a combination of SDAB and cancellous autologous bone and marrow are biocompatible, anatomically contoured, easily adapted at surgery, and the allogeneic component is biodegradable. They do not require elaborate internal metallic devices for structural support.

Adolescent↗

PubMed1977

Neurofibromatosis with central neurofibroma of the mandible: review of the literature and report of case.

The clinical, radiographic, and etiological factors of neurofibromatosis have been discussed. A rare case of a large neurofibroma of the mandible in association with systemic neurofibromatosis and a characteristic mandibular dysplasia has been presented. The unique coexistence of mandibular dysplasia associated with sphenoidal and orbital dysplasia should be considered in the diagnosis of multiple neurofibromatosis.

Bone Diseases↗

PubMed1976