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Biomedical subjects

D B Peacock

Publications and source records attributed to D B Peacock.

7 recordsLinked to original sources
PubMed1976

Immune response to phi X 174 in man. 5. Primary and secondary antibody production in primary biliary cirrhosis.

In primary biliary cirrhosis, the primary immune response to the bacteriophage phi X 174 is normal but the secondary response is significantly reduced. The reduction is primarily of IgG antibody, while IgM is proportionately less affected. These changes may be the result of a reduction in helper T lymphocyte function and may contribute to the increase in the ratio of serum concentration of IgM to IgG.

Adult↗
PubMed1975

The immune response to phi chi 174 in man. II. Primary and secondary antibody production in patients with Crohn's disease.

10 patients with Crohn's disease in various states of activity have been injected with 3.3 times 10-9 plaque-forming units of the bacteriophage phi chi 174, as a test for their capacity to produce antibodies. 9 patients had a completely normal primary and secondary antibody response. One patient had higher levels of preimmunization antibodies than have been encountered in normal subjects and developed a secondary (IgG) response to the first dose of antigen. We conclude that there is no evidence of a general disturbance of antibody-producing capacity in subjects with Crohn's disease.

Adult↗
PubMed1975

The immune response of phiX 174 in man. III. Evidence for an association between hyposplenism and immunodeficiency in patients with coeliac disease.

The ability of patients with coeliac disease to produce primary and secondary antibody in response to a new antigen has been tested. Eight patients with coeliac disease were injected intravenously with the coliphage phiX 174. Antibody levels were measured throughout the primary response. On day 28 a second injection was given and the secondary response was also studied in detail. The production of antibody in the primary response is lower than in a group of normal subjects. The secondary response is severely reduced and the difference between the coeliac group and controls is highly significant. The secondary response in the coeliac patients contains a much higher proportion of IgM antibody than normal. These abnormalities correlate approximately with clinical status and with hyposplenism. It is concluded that in patients with coeliac disease the ability to produce antibody is impaired, with a defect in switching from IgM to IgG antibody.

Adult↗
PubMed1975

The immune response to phichi174 in man. IV. Primary and secondary antibody production in patients with chronic lymphatic leukaemia.

Ten patients with chronic lymphatic leukaemia (CLL) were injected with the antigen phichi174 intravenously on two occasions to test their capacity for antibody production. Nine out of ten patients failed to develop a primary response, and five out of ten failed to develop a secondary response. Only one out of the ten of the secondary responses fell within the normal range. There was evidence of defective switching from IgM to IgG antibody in two out of three cases in which the immunoglobulin class of antibody in the secondary response was determined. The severity of the immunoparesis in CLL is related to the severity of the disease.

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