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Biomedical subjects

D B Sharma

Publications and source records attributed to D B Sharma.

At least 19 recordsLinked to original sources
PubMed1986

Pharmacokinetics of carbamazepine in protein energy malnutrition.

The pharmacokinetics of carbamazepine was studied in 6 children with protein energy malnutrition (PEM) and in 6 healthy children. Plasma carbamazepine was estimated by enzyme multiplied immunoassay technique. Single-dose concentration profiles after 10 mg/kg of the drug showed lower plasma peak levels. The systemic availability (AUC 0-48 h) of the drug in PEM was also reduced. Based on these observations, suggestions have been made for rescheduling the dosage of the drug in PEM.

Adolescent↗
PubMed1986

Pharmacokinetics of phenobarbitone in protein energy malnutrition.

Phenobarbitone kinetics was studied in malnourished and normal children after single oral dose of approximately 7.0 mg/kg. Estimation of serum phenobarbitone concentration was performed by spectrophotometric method. Elimination half-life was 58.9 +/- 9.5 h and 30.15 +/- 6.1 h for malnourished and healthy children, respectively. Compared to healthy children, tmax was prolonged in malnutrition group suggesting slow absorption in the latter group. The systemic bioavailability was observed to be higher in protein energy malnutrition. Modifications of the usual dosage regimen in malnutrition are recommended.

Absorption↗
PubMed1981

Hepatoblastoma.

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Carcinoma, Hepatocellular↗