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Biomedical subjects

D B Trash

Publications and source records attributed to D B Trash.

14 recordsLinked to original sources
PubMed1998

Systemic multifocal fibrosclerosis.

We describe a case of hydronephrosis as a result of retroperitoneal fibrosis in a patient who had previous sclerosing lobulitis of the breast. To the best of our knowledge this is the first reported association between these two conditions in the english literature. We presume these conditions are linked and unify them under the general heading of systemic multifocal fibrosclerosis.

Breast↗
PubMed1983

Ursodeoxycholic acid for the dissolution of radiolucent gall bladder stones.

In a prospective dosage response study of 84 patients with radiolucent gall bladder stones treated with ursodeoxycholic acid (UDCA), a dose of 500 mg daily was as effective as 1,000 mg daily. Complete dissolution of stones was achieved in 9 of 31 patients (29%) treated for at least 6 months with the lower dose, and in 7 of 33 patients (21%) on the higher dose. 4 patients in each group continue on treatment having shown partial gall-stone dissolution. When the two dosage groups were considered together, small stones dissolved more readily than larger ones and, after allowance for stone size, success rates were equal in obese and non-obese patients. Treatment with UDCA was well tolerated and significant adverse effects were not encountered.

Adolescent↗
PubMed1976

Pulmonary oedema during treatment of acute water intoxication.

Acute water intoxication with deepening coma and uncontrolled epileptiform seizures in a 25-year-old previously fit male schizophrenic was treated with hypertonic (2 N) saline and a 20% mannitol solution. This improved his neurological state but precipitated severe pulmonary oedema. Intravenous frusemide increased his urinary output sufficiently to clear the pulmonary oedema. In acute water intoxication the use of hypertonic solutions may thus precipitate left heart failure by expanding the intra-pulmonary blood volume beyond the capacity of even a healthy left ventricle to compensate. Simple water restriction will produce a slower but perhaps safer improvement.

Acute Disease↗
PubMed1975

Diagnositic value of serum bile acid estimations in liver disease.

Bile acid concentrations were estimated enzymatically in fasting and postprandial (two-hour) serum samples from 18 normal subjects and 30 patients with histologically proven hepatobiliary disease. The serum bile acid concentration was less than 15 mumol/1 in normal subjects and did not increase postprandially. The fasting serum bile acid concentration was raised in 27 of the patients with hepatobiliary disease, and following a meal was outside the normal range in all 30 patients. Other liver function tests were abnormal less frequently. These results suggest that the estimation of serum bile acids in the postprandial state is a sensitive screening test of hepatobiliary disease. They should be of particular value in patients in whom liver disease is suspected but not proven, and in those recovering from liver disease, especially following therapy.

Adolescent↗
PubMed1974

Use of bumetanide in the treatment of ascites due to liver disease.

Bumetanide is an effective diuretic for the treatment of ascites. Fifteen out of 17 patients with chronic liver disease responded satisfactorily and the incidence of hepatic encephalopathy and electrolyte disturbances was similar to that previously observed with frusemide. Colicky abdominal pain was reported in three patients but no other adverse effects were noted. An unexpected response was obtained in two patients who had diuresis without natriuresis.

Adolescent↗
PubMedDate not supplied

Safety of colonoscopy.

The deterioration of three patients with ulcerative colitis shortly following colonoscopy made us question whether this was related to the colonoscopy or bowel preparation, this trial was set up to answer this question. A total of 105 patients were recruited and underwent full bowel preparation and colonoscopy. Results showed that there was no statistically significant difference between patients with ulcerative colitis and controls with non-inflammatory disease in increase in bowel frequency, general well being or pain. In summary we conclude that full bowel preparation and colonoscopy in patients with ulcerative colitis managed as outpatients do not lead to a deterioration in their symptoms.

Adolescent↗