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Biomedical subjects

D B Uteshev

Publications and source records attributed to D B Uteshev.

13 recordsLinked to original sources
PubMedDate not supplied

[The effect of anti-asthmatic preparations on the proliferation of human peripheral mononuclear cells].

The authors studied the effect of some antiasthmatic drugs (theophylline, budesonide, sodium cromalyne) and beta-carotene in vitro on spontaneous and PHA-induced proliferation of human peripheral blood mononuclears (PBMN). It was found that the drugs had no effect on spontaneous cell proliferation. But budesonide caused a 4-fold and beta-carotene a 6-fold decrease of the index of PHA-stimulated PBMN proliferation. It is concluded that beta-carotene may be used in clinical practice as an anti-inflammatory agent for bronchial asthma treatment.

Anti-Asthmatic Agents↗
PubMedDate not supplied

[The anti-inflammatory activity of intal and beta-carotene in a model of experimental granulomatous lung inflammation].

A-25 sephadex-induced granulomatous inflammation of the lungs in rats was treated with beta-carotene and intal in inhalations. Both drugs showed antiinflammatory activity reducing the area of alveolitis and emphysema in the lungs, number of neutrophils and lymphocytes in the bronchoalveolar fluid. The experimental data allow to recommend further trial of intal and beta-carotene in granulomatous pulmonary diseases.

Animals↗
PubMedDate not supplied

[The protector properties of a pseudopeptide drug ingamine studied on a model of bronchospasm in guinea pigs].

The original pseudopeptide drug ingamine (4-[N-[2-(imidazol-4-yl)ethyl]-carbamoyl] butyric acid) was studied on the traditional model of antigen-induced bronchospasm in actively sensitized guinea pigs. The drug was introduced using various methods (by inhalation, via intragastric tube, and by intraperitoneal injections) in a range of doses (20, 50, 150, or 500 mg/kg). The new drug exhibited a pronounced dose-dependent protector action for all ways of introduction, but the most significant effect was observed upon inhalation, whereby the degree of bronchospasm inhibition exceeded 80%. In comparison to the reference drug sodium cromoglycate, ingamine (in equimolar doses) showed a higher activity with respect to the antigen-dependent bronchospasmic reactions. It can be expected that ingamine will provide for the effective treatment of bronchial obstruction under clinical conditions.

Animals↗
PubMedDate not supplied

[Adhesive molecules as drugs and objects of pharmacological effect in myocardial ischemia and reperfusion].

The modern advancements in the study of the mechanisms of reperfusion damage in myocardial infarction are analysed. Emphasis is placed on the leukocyte-endothelial interactions and the role of various adhesive molecules and cytokines. The effect of various biotechnological agents and drugs, products of chemical synthesis, on some links of the reperfusion syndrome are discussed. A classification of substances possessing a protective effect in ischemia/reperfusion is proposed.

Animals↗
PubMedDate not supplied

[Apoptosis: the pharmacological aspects].

The article deals with the latest achievements in the interpretation of the mechanism of programmed cell death (apoptosis). The effect of drugs on the different stages of the apoptotic signal conduction is analysed. The earliest prospects of creating apoptosis regulating agents are planned. It is suggested that tests for apoptosis should be included in the list of obligatory ones in the preclinical studies of new biologically active compounds.

Animals↗
PubMedDate not supplied

[Current concepts of the structure and functions of retinoid receptors].

The article discusses the principal structure of nuclear receptors. The structure and function of retinoid receptors, their main ligands and inhibitors are analysed. Data (experimental and clinical) concerning the immunotropic antineoplastic and cardiovascular activity of the main retinoids are given.

Animals↗