[Cytogenetic effects of hyperbaric factors].
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Biomedical subjects
Publications and source records attributed to D B Vandyshev.
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The effect of high pressure on the Fe-ascorbate-induced lipid peroxidation in liposome suspensions has been studied. It was found that hydrostatic or helium pressure up to 140 bar increases the rate of MDA accumulation in this model system. This effect is assumed to be connected with the gain in polarity of the lipid bilayer under hyperbaric conditions.
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The comparative analysis of pressure effects of helium, nitrogen (to 100 kg/cm2), cryptone (to 50 kg/cm2) and temperature (32-45 degrees C) on the lateral diffusion of pyrene in liposomal membranes of egg phospholipids was performed. The linear additivity of studied effects was demonstrated. The results are discussed from the point of view of the disturbances of cell processes in the hyperbaric conditions.
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