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Biomedical subjects

D B Weeks

Publications and source records attributed to D B Weeks.

11 recordsLinked to original sources
PubMed1978

Physiologic saline solution, Normosol R pH 7.4, and Plasmanate as reconstituents of packed human erythrocytes.

The authors compared the effects of three reconstituent solutions (Normosol R pH 7.4, physiologic saline solution, and Plasmanate) on hemolysis and cellular morphology of young (8-10 days' storage) and old (22-26 days' storage) packed human erythrocytes (PE). These variables were tested at 22 and 37 C and at two dilutions )1 part PE:1 part reconstituent and 2 parts PE:1 part reconstituent). Plasmanate produced unacceptably high levels of hemolysis, particularly of older PE, and should not be used as a reconstituent. Normosol R pH 7.4 and physiologic saline solution were compatible with both young and old PE, producing similar changes in hemolysis and erythrocytic morphology, Therefore, Normosol R pH 7.4 may be used as a diluent for PE when rapid and massive infusions are needed.

Blood Proteins↗
PubMed1976

Provision of endogenous and exogenous humidity for the Bain breathing circuit.

The endogenous humidity produced by a partial rebreathing system, the Bain Breathing Circuit, was measured clinically and experimentally. The addition of humidification by interposing a Garthur Vapor Condenser (HME) or a Bennett Cascade heated humidifier into the system was also studied. Without supplemental humidity, the Bain Breathing Circuit probably meets marginal requirements for preservation of ciliary morphology and function during endotracheal anaesthesia. However, additional humidity is needed to prevent alteration in pulmonary mechanics. The HME is a beneficial adjunct to the Bain Breathing Circuit, raising humidity to near acceptable levels, especially if ambient temperatures range from 24 degrees to 26 degrees C. However, the deadspace of the HME is 17 ml, which might limit its use in children. The Bennett Cascade humidifier plus the Bain Breathing Circuit satisfies minimal suggested humidity requirements at ambient reservoir water temperatures of 24 degrees to 26 degrees C. Heating the reservoir water to maximum heat capacity increased humidity but caused marked water condensation along the inner fresh gas tube of the Bain Breathing Circuit.

Adolescent↗
PubMedDate not supplied

Airway maintenance in patients with long-term endotracheal intubation.

Long-term endotracheal intubation in seriously ill patients is frequently complicated by nosocomial infection of the tracheobronchial tree, especially with aerobic gram negative bacilli. A further complication is drying of pulmonary secretions unless the medical gases given are humidified. The performance characteristics of humidifying system used in spontaneously breathing, intubated patients is described. This system possesses the potential to decrease infection, provides physiologic humidification without nebulization, and, by avoiding air dilution, allows the administration of a precisely regulated FIO2.

Cross Infection↗