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Biomedical subjects

D Böhmer

Publications and source records attributed to D Böhmer.

At least 37 records · Page 2Linked to original sources

[The first period in the history of the Institute for General Biology].

Of the history of the Institute for General Biology, School of Medicine, Comenius University, the study deals with the first period, namely the years 1923-1945. The institute greatly benefited from the activities of Prof. MUDr. Zdenĕk Frankenberger who established it and was its Head in the first year of its existence. From 1925 till 1943 the institute was directed by Prof. MUDr. Jozef Florian Babor. Professor Babor's main interest was focused on malacology and he achieved international reputation in this field of zoology. He investigated the flora and fauna of Slovakia, was engaged in limnology, and cooperated with Professor Frankenberg in the field of anthropology and primatology. Over these years, prof. Vojtech Nábĕlek and MUDr. Bohumil Krajnik greatly contributed to the activities and development of the institute along with Prof. Babor. The Institute for General Biology was already in the first period of its existence reknown not only for its teaching activities but was also internationally appreciated in the medical, biological and historiographic community.

Academies and Institutes↗

[Possibilities of prevention of congenital developmental defects].

One of the still open questions of teratology is the relationship between experimental teratological investigations and their validity in human medicine. The aetiology of the development of inborn developmental defects comprises factors the ratio of which is the subject of discussions. The category of still unknown factors is the largest one. This means that in 70% of inborn developmental defects there is nothing to go by. The influence of the deteriorated living or working environment need not be manifested by a higher incidence of seriously damaged foetuses. Comprehensive preconception care is a way which may lead to improvement in the sphere of prevention, although its application is not unequivocal. An essential prerequisite of effective prevention of inborn developmental errors is recognition of the causes of and laws governing their development.

Congenital Abnormalities↗

[Radiological heart volume determination--a new method carried out in the sitting position (author's transl)].

A method is described for the determination of cardiac volume with the subject in a sitting position. The results correspond with those of other accepted methods, but there are several significant advantages: 1. The position is easily maintained by the subject and the method is therefore acceptable for patients with cardiac disease. 2. The risks connected with a Valsalva effect are reduced. 3. There is no need to change the position of the x-ray tube during the examination. 4. Contrary to the traditional technique, the x-ray room does not require a very high ceiling. 5. Because of even blood distribution, the cardiac volume determinations also provide information regarding the lungs.

Adult↗

Correlation between increased dopamine-beta-hydroxylase activity and catecholamine concentration in plasma: determination of acute changes in sympathetic activity in man.

In 11 healthy untrained volunteers the increase in plasma dopamine-beta-hydroxylase (DBH) activity during graded physical exercise has been examined as a true measure of increased activity of the sympathetic nervous system. The correlation between DBH activity, catecholamine concentration (CA) in plasma and heart rate was studied. When work on an electrically braked bicycle ergometer was gradually increased from 12.5 to 100, 200 and 300 watts there was a linear increase in DBH activity and heart rate; the increase in CA concentrations followed an exponential function. The peak values for DBH activity and CA concentration in plasma after the 300 watt work load (as percentages of the resting levels) were 130+/-3% and 820+/-71%, respectively; the adrenaline concentration in plasma increased only to 150+/-19% (p less than 0.05). There were significant correlations between heart rate and work load, DBH and work load and log CA and work load. The data imply direct correlations between heart rate and DBH, heart rate and log CA and DBH and log CA. The exponential increase in noradrenaline concentration in plasma might be due either to a greater net ""overflow'' from sympathetic nerve endings, and/or to increased secretion by the adrenal medulla. In the latter case, the release of noradrenaline would not be accompanied by secretion either of adrenaline or DBH. After work ceased there were sharp falls in heart rate and CA concentration, which indicate an immediate drop in sympathetic activity. DBH activity in plasma returned to normal very slowly; it reached half maximum values after 20-22 min. It is concluded that increased sympathetic activity in man can be estimated in vivo as changes in DBH and/or CA concentration in plasma. In contrast, a rapid decrease in sympathetic activity is directly reflected only by a rapid fall in the plasma concentrations of CA.

Epinephrine↗