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Biomedical subjects

D Balikdjian

Publications and source records attributed to D Balikdjian.

At least 19 recordsLinked to original sources
PubMed1988

Six-year results of a multimodality treatment strategy for locally advanced breast cancer.

Between 1976 and 1982, 59 patients with locally advanced breast cancer were treated with preoperative supervoltage radiotherapy, adjuvant preoperative and postoperative hormonochemotherapy, and modified radical mastectomy. Systemic treatment, which was started simultaneously with radiotherapy, consisted of a combination of daily oral tamoxifen and a monthly alternation of Doxorubicin + vincristine and cyclophosphamide + methotrexate + 5-fluorouracil (CMF). One of each cycle was given preoperatively at half dosage and five of each were repeated postoperatively at full dosage. All patients became operable. Results of pathologic examination of the operative specimen, available in 51 patients, showed complete disappearance of tumor tissue in breast areas in eight patients, of which three still had positive axillary nodes. After a median follow-up time of 6 years locoregional failure was observed in 12 patients (20%) but in only three (5%) did it occur before distant failure. The actuarial median survival of the entire patient population is close to 4 years. Seven patients are alive without recurrence at greater than 9 years. This aggressive multidisciplinary treatment approach is associated with a projected 30% long-term survival (10 years), excellent local control, but substantial toxicity.

Adult↗
PubMed1987

Detection of gastroduodenal ulcers using technetium-99m-labeled sucralfate.

Sucralfate is an effective medication for treatment of gastroduodenal ulcers, and 99mTc-labeled sucralfate has been found to adhere to ulcers. In this study, we examined the reliability of confirming the diagnosis of gastroduodenal ulcers--previously detected by endoscopy and histology--by means of sucralfate labeled with 99mTc, imaging 1 and 2 hr after oral administration. Eighteen out of 23 patients were positive by scintigraphy with this method (sensitivity = 78%). In five patients with gastroduodenal bleeding, the study was positive. The procedure was well tolerated and offered a noninvasive procedure that can be performed at the bedside in critically ill patients, and in follow-up of fragile patients.

Adult↗
PubMed1986

Which diphosphonate for routine bone scintigraphy (MDP, HDP or DPD)?

Of 790 patients, 772 with proven cancerous disease have been studied without any selection using either MDP (three different kits), HDP (two types) or DPD. The groups were identical in age distribution, male/female ratio, body weight and verified percentage metastatic involvement. Technical conditions (Mo/Tc-generator used, dilution volume, total activity of the final product per vial, preparation/injection and injection/examination delays) were identical. Analogous scintigrams according to qualitative criteria (image quality, bone delineation, soft tissue fixation, metastatic/normal tissue contrast, aspecific uptake by non-target organs) and superior to MDP. Quantitative data were quite similar for all types of diphosphonates spine; metastatic/normal bone fixation ratio, bone/soft tissue ratio) have been evaluated. The results obtained showed that there was no criterion to demonstrate that HDP or DPD would be superior to MDP. Quantitative data were quite similar for all types of diphosphonates studied. Two out of the three MDPs were slightly superior to the other products with regard to detectability of metastatic lesions. Our results show, that in non-selected clinical routine work for bone scintigraphy HDP and DPD do not present any decisive qualitative or quantitative advantage in comparison to MDP.

Adolescent↗
PubMed1985

[Cancer of the endometrium and radiotherapy. Review of 280 patients treated at the Institut Bordet].

280 patients were treated at the Institute Bordet between 1963 and 1977 for endometrial carcinoma. 149 patients had radiotherapy alone, 65 patients had radiotherapy before operation and 66 patients after operation. Radiation alone was reserved for those patients whose operative risk was very serious. Five year survival was 49.6% after irradiation alone in Stage I tumours (A "packing" technique was used to deliver the radiation therapy). 22.7% of these patients died of intercurrent diseases. The majority of the recurrences were in the uterus. This series confirms the prognostic importance of the clinical staging, of the length of the uterine cavity and the degree of differentiation of the tumour. The five year survival rate after postoperative irradiation is 75%, and 84% after preoperative irradiation. Though the association of surgery with irradiation gives better results for those patients who can be operated on, it must be pointed out that radiotherapy alone gives a chance of curing an important percentage of patients whose surgical risk is in a major category.

Combined Modality Therapy↗
PubMed1982

Experience of telecobalt therapy in operable breast cancer at J. Bordet Institute (1969-1975).

Between 1969 and 1975, postoperative radiotherapy was performed at the J. Bordet Institute on 787 stage I-III operable breast cancer patients. Crude 10 years survival rates are respectively 61% for stage I, 59% for stage II and 30% for stage III. The results have been analysed according to clinical characteristics of significant prognostic value and according to the technical conditions of treatment. The status of the axillary nodes appears to be the most important prognostic factor. Radiotherapy to the thoracic wall and lymph drainage areas has varied little throughout the whole period with the dose to the internal mammary chain being the only parameter which varied significantly. Loco-regional recurrences occurred only in 5, 2% of patients without distant metastases appearing previously or during the following year (2.4 for stage I patients). Severe sequelae were seen in only a very few cases. Survival appears significantly correlated with an adequate dose of irradiation to mammary node chain.

Breast Neoplasms↗
PubMed1979

[Lethal midline granuloma. A case report].

In their study of a case of lethal midline-granuloma, the authors describe the relations between this affection, Wegener's granulomatosis and lymphoma. The case under review illustrates the difficulty in accurately defining the nosologic picture of the disease. Anatomo-pathological examinations present two possibilities: one being malignant granuloma of the Stewart type, the other that of lymphoma. From its subsequent evolution, we may eventually learn whether this is purely a local illness or represents the onset of a systemic disease.

Granuloma, Lethal Midline↗
PubMed1975

[Effects of radiotherapy on plasma T 1/2 59Fe in patients with lung cancer and lymphomas].

The variations of the plasma 59Fe T 1/2 were observed in 20 patients treated by high-energy irradiation. They were submitted to a focalized radiotherapy involving a non-negligible volume of erythropoietic marrow. Among them there were 10 cases of pulmonary cancer, 7 cases of lymphomas, and 3 cases of seminomas. When treatment was limited to an irradiation of the thorax, no significant change of the 59Fe T 1/2 was observed in cases of pulmonary cancer or lymphomas. In case of a supra and infradiaphragmatic irradiation (lymphomas), the 59Fe T 1/2 (initially subnormal) tended to reach normal values after radiotherapy and seems to be independent of the initial value (before irradiation) and of the delivered dose.

Cobalt Radioisotopes↗