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Biomedical subjects

D Bang

Publications and source records attributed to D Bang.

At least 37 records · Page 2Linked to original sources
PubMed1997

Treatment of Behçet's disease.

Behçet's disease is characterized with multifactorial etiopathogenesis and multiclinical pictures. The treatment of patients with Behçet's disease is based on the severity of illness, and the most appropriate management of Behçet's disease requires a multidisciplinary approach. Although various therapeutic modalities have been employed for Behçet's disease, treatment is far from satisfactory. Treatment of Behçet's disease includes local, systemic, or surgical therapies. Limited success has been found with colchicine, azathioprine, indomethacin, cyclophosphamide, chlorambucil, levamisole, transfer factor, fibrinolytic therapy, and systemic corticosteroid. New therapeutic approaches have been introduced for Behçet's disease using cyclosporine, thalidomide, interferon, acyclovir, high-dose corticosteroids or cyclophosphamide pulse therapy, and FK 506. We suggest that therapeutic agents should be selected after thorough evaluation of the immune state of each patient by using various tests and by determining any aggravating or provoking factors involved. In general, a combination-agent regimen is more effective than a single-agent regimen. Early diagnosis and proper treatment can inhibit or at lease slow the progress of the disease remarkably.

Adrenal Cortex Hormones↗
PubMed1997

Epidemiological and clinical features of Behçet's disease in Korea.

Behçet's disease occurs with a high prevalence in the Far East including Korea. In this report we inspected 1,155 patients with Behçet's disease and collected information concerning the clinical and epidemiologic features of Behçet's disease in Korea. In summary, patients in their 30s were the most common, with the most common age of onset in the 20s; the sex ratio was 0.63:1 with female predominance; according to revised Shimizu's classification, the order of frequency of the different types was incomplete (38.2%), suspected (25.4%), possible (20.3%) and complete (16.1%); oral ulcers were the most frequent major symptom (97.5%) and the most common initial symptom (78.5%); erythema nodosum-like lesion (55.3%) was the most common type of skin lesion; a seasonal aggravation of the disease was observed in 21.3% of patients; and the most common type of childhood onset Behçet's disease was suspected type.

Adolescent↗
PubMed1997

The influence of pregnancy on Behçet's disease.

Behçet's disease is a multisystem disorder that affects mainly young adults. Conflicting reports of the effects of pregnancy on the course of Behçet's disease have been reported. We studied 27 pregnant women with Behçet's disease using questionnaires, clinical examination, and laboratory tests. The condition of 18 patients worsened (66.7%) and 9 patients (33.3%) improved during pregnancy. In the deteriorated group, clinical exacerbation of Behçet's disease occurred most commonly during the first trimester (77.8%). They were primarily of the suspected or mucocutaneous type, while in the improved group, the majority of patients were of the incomplete and complete type, or the arthritic and ocular type. Of interest was the fact that all patients in the improved group showed exacerbations related to menstruation or postpartum, which indicated that progesterone may be the major hormone influencing the course of Behçet's disease.

Adult↗
PubMed1996

Polymerase chain reaction reveals herpes simplex virus DNA in saliva of patients with Behçet's disease.

The etiology of Behçet's disease is unclear, but viral infection is thought to be one etiologic factor. The aims of this study were to detect herpes simplex virus (HSV) DNA in the saliva of patients with Behçet's disease and of healthy persons, to determine whether the presence of HSV in saliva is associated with the presence of intraoral ulcer, and to investigate the relationship between HSV and Behçet's disease. The polymerase chain reaction (PCR) was used to detect HSV DNA sequences in DNA extracted from the saliva of patients with Behçet's disease and of healthy control subjects. Of 66 patients with Behçet's disease diagnosed clinically, 19 were diagnosed as complete type, 29 as incomplete type and 18 as suspected type. Of 66 DNA preparations from the saliva of the patients, 26 (39.4%) showed the 289-bp band. This contrasts with 12 of 87 preparations (13.8%) from healthy controls (P < 0.01). There were no significant differences among the three patient groups. All the 289-bp bands analyzed by restriction endonuclease digestion yielded the expected 158-bp and 131-bp fragments when digested with PstI.HSV DNA was detected in 12 of 33 Behçet's disease patients (36.4%) with oral ulceration and 14 of 33 patients (42.4%) without oral ulceration at the time of testing. There was no statistically significant correlation in the PCR results between the two groups.

Base Sequence↗
PubMed1996

Antiphospholipid syndrome associated with progressive systemic sclerosis.

We report a case of secondary antiphospholipid syndrome (APS) occurring in a progressive systemic sclerosis (PSS) patient who took herbal medication. Clinical findings compatible with APS included positive IgM anticardiolipin antibody (ACL), thrombocytopenia, and obstruction of the left radial artery on digital subtraction angiography (DSA). Clinical findings compatible with PSS included sclerodactyly and digital ulcers, Raynaud's phenomenon, pulmonary fibrosis and pulmonary hypertension, proteinuria and renal mesangial reaction, and myocarditis.

Antiphospholipid Syndrome↗
PubMed1996

Appearance of Sézary-like atypical lymphocytes in the regressing lesions of juvenile xanthogranuloma. Its role in the spontaneous regression.

A case of juvenile xanthogranuloma of the skin was sequentially biopsied for 10 months. In the electron microscopic examination of the regressing lesions, we observed that cells with highly indented nuclei, Sézary-like cells, were in close apposition to vacuolated degenerating histiocytes in many foci. In immunohistochemical stain, the number of UCHL-1+ cells were increased in regressing lesions compared with early lesions. We speculate that these Sézary-like atypical lymphocytes may be closely related to the spontaneous regression of juvenile xanthogranuloma.

Female↗
PubMed1996

Ecthyma gangrenosum associated with aplastic anemia.

Ecthyma gangrenosum is a characteristic skin lesion of systemic infection due to Pseudomonas aeruginosa. It has a high incidence in patients with chronic disease and impaired defense mechanisms. Early diagnosis and appropriate systemic antibiotic therapy is crucial since its mortality rate is very high. We report a case of ecthyma gangrenosum in aplastic anemia.

Adult↗
PubMed1995

Prognosis and clinical relevance of recurrent oral ulceration in Behçet's disease.

There is no way of predicting whether a patient with recurrent oral ulcerations (ROU) will develop Behçet's disease (BD). In the absence of a valid laboratory test to exclude BD, such oral ulcerations result in a diagnostic problem when they occur as the sole and earliest manifestation of disease. We assessed the prognosis of ROU by performing prospective evaluations of 67 patients who had only a history of ROU and were registered at the Behçet's Disease Specialty Clinic at Severance Hospital of Yonsei University, Seoul, Korea. Thirty-five patients (52.2%) developed overt manifestations of BD at an average of 7.7 years after the onset of ROU. The frequency of recurrence was 9.8 times per year in progressive cases. From these results, it appears that highly recurrent ROU is a warning signal for BD. Careful examinations of patients, including their minor symptoms, additional laboratory tests, and regular follow-ups by physicians are required for proper diagnosis.

Adolescent↗
PubMed1995

Electron microscopic observation of erythema nodosum with the eosinophilic infiltration. A case report.

The presence of eosinophils localized within an inflammatory skin lesion of a patient with erythema nodosum has been studied by electron microscopy. Among the intact eosinophils seen in the cellular infiltration, some underwent necrosis and released membrane-bound, free eosinophil granules into the interlobular septa of the subcutaneous fat. Such granules, identified by their central crystalline cores, often showed granular changes with core dissolution and were found scattered in the edematous space between the collagen bundles. A few intact eosinophils that showed minor alterations of cytoplasmic granules were also present. The significance of these findings, which may enhance endothelial permeability, is discussed.

Adult↗
PubMed1994

Tick bites in Korea.

BACKGROUND: Tick bites are dermatoses not commonly encountered in Korea. Recognizing their clinical signs as well as their histopathologic findings is important in making a diagnosis of tick-related dermatoses. The incidence and causative species are different depending on the geographic areas. The histopathologic findings of tick bites are known to be a variable depending on the species of ticks involved and the duration of their bloodsucking. METHODS: Five ticks were collected from five patients and three of them were identified as Ixodes (I.) nipponensis. RESULTS: Histopathologic findings of panniculitis were prominent in four of five cases; septal panniculitis in two cases, and lobular panniculitis in the other cases. CONCLUSIONS: Ixodes nipponensis was the most common causative species of ticks responsible for tick bites in Korea, and tick bite panniculitis must be considered in the differential diagnosis of panniculitis which is mainly composed of neutrophils.

Aged↗
PubMed1994

Clinical analysis of 40 cases of childhood-onset Behçet's disease.

Behçet's disease is a chronic, relapsing, idiopathic, multi-system condition characterized by mucocutaneous, ocular, gastrointestinal, articular, vascular, urogenital, and neurologic involvement. Usually the onset occurs between 20 and 30 years of age; it is very uncommon in children. We analyzed 40 cases of childhood-onset Behçet's disease. The male:female ratio was 0.67. The most frequent major sign was oral ulceration, appearing in all patients. Other major signs were genital ulcers (33 patients), skin lesions (29), and ocular lesions (11). The average time interval between the initial oral ulceration and the second major manifestation was 8.8 years. After the second major manifestation, the third and fourth features rapidly developed within one to two years. The most frequent minor sign was arthritis, occurring in 11 of 40 patients. Intestinal, neurologic, and renal involvement was also present. From our results, we concluded that oral ulceration, which is the most common initial manifestation, should not be neglected in children, since it may signal Behçet's disease.

Age of Onset↗
PubMed1994

Persistent erythema infectiosum-like rash as a prodrome of acute lymphocytic leukemia.

A 7-year-old boy had erythema infectiosum with typical manifestations. Over more than 40 days, these lesions showed no sign of regression, and chronic anemia became progressively more severe. Electron microscopic examination performed 20 days after onset showed abnormal Sezary-like lymphocytes. Bone marrow biopsy, which was performed to evaluate the anemia, was consistent with acute lymphocytic leukemia. Persistent parvovirus B19 infection may be connected with immunosuppression. Therefore, early electron microscopic study and bone marrow biopsy may be helpful for early diagnosis of hematologic malignancies.

Anemia↗
PubMed1993

New procedure for analysing drug binding data, exemplified by warfarin binding to human serum albumin.

Determination of binding constants for multiple binding of a ligand usually results in highly variable figures. We have found that the variations depend mainly upon cooperativity of ligand binding, and that cooperativity is generally absent on binding to human serum albumin. When this is taken into account it becomes possible to obtain binding constants with only slight variation. A computerized curve fitting procedure for analysing binding data has been established consisting of the following steps. (1) Fitting of Scatchard's equation to observed binding equilibrium data to obtain a best-fit set of Scatchard binding constants. (2) Repetition of the fitting procedure, not to obtain a best fit but to generate 30 acceptable sets of Scatchard binding constants. (3) Fitting of Adair's equation to the observed points to obtain a best fit. If the sum of weighted and squared deviations is significantly smaller than the fitting of Scatchard's equation, cooperativity should be considered. If not, cooperativity cannot be demonstrated and the binding constants obtained by fitting Scatchard's equation can be accepted, with the variations found. (4) Final transformation of all Scatchard constants to Adair's. To illustrate the method warfarin data obtained by equilibrium dialysis was used.

Binding Sites↗
PubMed1993

Ultrastructure of endothelial cell necrosis in classical erythema nodosum.

As evidence of vascular involvement in classical erythema nodosum unassociated with Behçet's disease, the occurrence of endothelial cell necrosis based on the development of dark cell degeneration was observed by electron microscopy in the vasculature of the dermis and subcutaneous fat. The incidence of endothelial cell necrosis in all segments of the microcirculatory system was roughly 20% in three of 12 patients. The remaining nine patients showed a very low rate of necrosis, including two patients in whom endothelial cell necrosis was totally absent. The presence of necrotic endothelial cells that are forced out and eliminated by neighboring intact endothelial cells into the vascular lumen is closely associated with thrombus formation in the cutaneous vasculature. The incidence at which endothelial cell necrosis occurs in classical erythema nodosum is not always high; however, it is concluded that endothelial cell necrosis may play a significant role in the pathogenesis of erythema nodosum.

Adult↗
PubMed1993

Clinical study on death in Behçet's disease.

We were able to identify 7 patients who died of Behçet's disease, among 2,200 patients registered at the Behçet's Disease Specialty Clinic of Severance Hospital from November 1983 to October 1992. Six were male and one female. Age of death was 31 to 55 years with the mean age of 39.1. The age of onset was 24 to 54 years with the mean age of 32.6. The mean duration of illness was 6.5 years. The most frequent initial symptom was oral ulcer, with the most common type being the incomplete type in Shimizu's classification. Positive pathergy tests were found in all the 5 patients in whom the test was performed out of 7 patients. Various modalities of treatments such as oral steroid, colchicine, azathioprine, colectomy, and pacemaker insertion were attempted without outstanding therapeutic effects. The causes of death were gastrointestinal bleeding, bowel perforation, superior and inferior vena cava syndrome, aortic regurgitation, cerebrovascular disease, sepsis, and lung abscess.

Adult↗
PubMed1992

Acne fulminans and 13-cis-retinoic acid.

We report a case of acne fulminans occurring during treatment with 13-cis-retinoic acid for cystic acne. Continuing the treatment with 13-cis-retinoic acid without systemic steroid eventually cleared the systemic manifestations and skin lesions. We review the literature and discuss its pathogenesis.

Acne Vulgaris↗
PubMed1992

Hair follicle nevus.

Four cases of hair follicle nevi are described. Hair follicle nevus is an extremely rare hamartoma occurring on the face, which has had no clear histopathologic definition until now. A short review of the clinicopathologic features of this disease is presented.

Adult↗