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Biomedical subjects

D Barbieri

Publications and source records attributed to D Barbieri.

At least 91 records · Page 5Linked to original sources

[M-mode echocardiography: determination of morphological parameters in the normal newborn infant].

The purpose of this study is to establish normal echocardiographic values of 25 parameters in the newborn infants. The study group is composed of 100 normal, healty neonates (of 72 to 96 hours of age), from whom echocardiograms and measurements were obtained in a standardized manner. Criteria have been established for a complete echocardiographic profile in the full-term newborn. In addition, attempts have been made to correlate the most relevant measurements with body surface area. No significant correlation was found to exist in the small range we have studied (BSA = 0,16 - 0,26 m2).

Echocardiography↗

Anomalies of the long arm of chromosome 11 in human myelo- and lymphoproliferative disorders. I. Acute nonlymphocytic leukemia.

In a series of 365 consecutive ANLL cases of which 45.1% had abnormal karyotypes, 13 cases were detected with a structural abnormality of the long arm of chromosome 11. Besides one isochromosome 11q, there were six deletions and six translocations. Of these 12 patients, seven had acute monocytic leukemia (FAB-type M5), two had an M4, two had an M2, and one case of secondary leukemia had an M3-like disorder. Similar results with regard to the type of leukemia were obtained upon analysis of 41 cases of ANLL with an 11q anomaly described in the literature. This study confirms that a high proportion of acute monocytic leukemias and a lesser proportion of acute myelomonocytic leukemias are characterized by an 11q anomaly, mostly involving bands q22 and/or q23. Acute monocytic leukemia with an 11q structural anomaly appears to have a poor prognosis.

Acute Disease↗

3q-, 3q+ anomaly in malignant proliferations in humans.

Anomalies of both No. 3 chromosomes, of the t(3q-; 3q+) type can be observed in human malignancy as reported previously. It is our experience that this anomaly is found predominantly in myeloproliferative disorders, as a rather rare event, though occurring more frequently than similar exchanges between other homologous chromosomes. Previous claims about a relationship between this anomaly and thrombocytosis could not be confirmed, but the features found in a few patients indicate that further research should be undertaken to clarify this point.

Adult↗