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Biomedical subjects

D Bartko

Publications and source records attributed to D Bartko.

At least 19 recordsLinked to original sources
PubMed1991

[The spinal canal, dural sac and spinal cord on cervical myelograms. Possibilities of quantification using a computer].

The objective of the presented work was to investigate anatomical structures of the cervial spine and their interrelations on cervical myelograms in a neutral position and in retroflexion. Cervical myelograms were made in 34 patients from a lateral approach between the first and second vertebra. In a neutral position and in retroflexion the relations of the dural sac and spinal canal were investigated in 26 subjects with a normal antero-posterior diameter of the spinal canal and in eight patients with congenital stenosis of the spinal canal. Quantification by means of a computer revealed that in retroflexion the antero-posterior diameters of the dural sac diminishes significantly in subjects with a normal antero-posterior diameter of the spinal canal as well as in subjects with congenital stenosis of the spinal canal. Moreover, the authors provided evidence that the area of the dural sac diminishes significantly in retroflexion, as compared with the neutral position in subjects with a normal spinal canal as well as in subjects with congenital stenosis of the spinal canal.

Cervical Vertebrae↗
PubMed1990

[Specific aspects of mobility and changes in the shape of the dural sac in functional lumbosacral myelography].

The purpose of the work was an analysis of lateral myelograms of the lumbosacral spine in the neutral position, in anteflexion and retroflexion from the aspect of the mobility of the dural sac and its relationship to the spinal canal. The group comprised 50 patients with clinically obvious discopathies and other vertebrogenic syndromes. The areas of the dural sac were measured planimetrically and evaluated by means of a computer. It was revealed: 1. The Soinal canal and dural sac are not static variables but dynamic ones. By movements of the lumbosacral spine the size of the dural sac changes and so does its shape. These phenomena can be evaluated not only qualitatively but also quantitatively. 2. The anteroposterior diameter of the dural sac on the myelograms in anteflexion and in retroflexion changes significantly, as compared with the neutral position, it increases during anteflexion and diminishes during retroflexion. 3. The area of the dural sac increases during anteflexion and diminishes in retroflexion, as compared with the neutral position. 4. Changes in the shape of the dorsal portion of the dural sac revealed in the segment of the discopathy are considered to be due to hypertrophy of the yellow ligaments.

Dura Mater↗
PubMed1990

Electrophysiological characterization of central sensory and motor pathway function in patients with moderate hemiparesis. I. Methodical approach.

The central sensory and motor pathway function in healthy persons and patients with several neurological disorders was selectively characterized by evaluation of latencies of short (R1) and long (R2) latency EMG responses as well as simultaneously recorded somatosensory potentials (N19, N26) evoked by electrical stimulation of N.medianus and N.peroneus. On the basis of these latencies the peripheral and central sensory/motor conduction times were calculated. By using this investigation procedure a selective quantification of central pathway functions is possible.

Adolescent↗
PubMed1990

Electrophysiological characterization of central sensory and motor pathway function in patients with moderate hemiparesis. II. Clinical results.

The central sensory and motor pathway function in patients with moderate hemiparesis and in healthy persons was selectively characterized by evaluation of latencies of short (R1) and long (R2) latency EMG responses as well as simultaneously recorded sensorimotor potentials (N19, N26) evoked by electrical stimulation of median and peroneal nerve (additionally, calculation of peripheral and central sensory/motor conduction times). This investigation procedure permits a noninvasive quantification of disturbed central sensory and motor pathway function in hemiparetic patients. The results found are in agreement to clinical, CT and other examination findings.

Adolescent↗
PubMed1990

[Venous angiomas of the brain. Retrospective study of angiograms and clinical material].

The aim of the investigation was to reveal the existence of venous angiomas of the brain by serioangiography in selected neurological diseases and to test the possible connection between the angiographic finding of a VA and neurological symptomatology. The material was formed by 386 serioangiograms in patients with subarachnoid haemorrhage, intracerebral haemorrhage, focal epilepsy and unilateral headache. It was revealed that from the total number of mentioned diagnoses there were 18 venous angiomas, i.e. 4.66%. Intracerebral haemorrhage and unilateral headache were most frequent (7.3% and 9%). No difference was found between the right and left hemisphere and between different brain areas. Cerebral angiography remains an important method in the diagnosis of venous angiomas of the brain, provided a satisfactory programme and high quality material are used. Examination by computed tomography without a contrast is of little diagnostic value, the use of contrast in computer tomography can improve the diagnosis.

Brain Neoplasms↗
PubMed1990

[Intracerebral hemorrhage in hypertensives: diagnosis, therapy and prognosis].

The authors analyzed 98 cases of intracerebral haemorrhage in hypertonic subjects from the aspect of the clinical course, CT findings and therapeutic results. Thirty-seven patients were treated by surgery and 61 had medicamentous treatment. The acute mortality rate in operated patients was 57% in non-operated ones 30%. The patients with haemorrhage in the putamen formed the majority of the group and had a higher mortality rate than patients with other sites of haemorrhage. The state of consciousness on admission and the size of haematomas influenced in a significant way the acute mortality rate of patients. Fifty-nine patients were followed up for an average period of 34 months. Of those 19% died and 54% attained a fair restoration of the clinical condition. Only 5% returned to work.

Adult↗
PubMed1990

[An unusual CT image of an ischemic focus].

In a 39-year-old man with focal cerebral ischaemia an uncommon CT picture of an ischaemic focus is described. The first CT examination was made two weeks after the development of the disease. After administration of the contrast substance an increased density along the fronte-parietal gyrification was detected. The finding was not typical for an ischaemic lesion. Two weeks after the first CT examination the examination was repeated. After administration of the contrast substance only at some sites the original increased density along the gyrification was found.

Adult↗
PubMed1989

[Specific cell-mediated cytotoxicity in patients with cerebral infarct].

The purpose of the work was to assess changes in the activity of cytotoxic lymphocates in patients with cerebral infarction. The material comprised 27 patients with the diagnosis of cerebral infarction and 18 controls. The authors analyzed the activity of cytotoxic lymphocytes, against the cerebral antigen-encephalitogenic peptide (EP). As target cells they used syngenic lymphocytes coated with EP and labelled with 51Cr, the activity of which released during reaction with supernatan is proportional to the amount of cells disrupted by cytotoxic lymphocytes. The reaction is specific for the encephalitogenic peptide. The activity of specific cytotoxic lymphocytes was in patients with cerebral infarction almost four times higher than in controls. The percentage activity was higher in "seriously affected patients" and two weeks after the onset of the disease. Then the activity declined. Investigation of the activity of cytotoxic lymphocytes could prove important in patients with cerebral infarction with symptoms of sensitization against cerebral antigen.

Adult↗
PubMed1989

[Changes in carbohydrate metabolism before and after the development of focal cerebral ischemia. III. Function of the diencephalon].

The purpose of the investigation was to assess whether the mechanism of reduced glucose tolerance in focal ischaemia of the brain can be considered a functional disorder of the regulatory brain centres or a manifestation of inadequate glucose utilization due to impaired insulin secretion. The function of centres regulating metabolic processes was tested by the i.v. administration of Pyrifer. It was revealed that after Pyrifer administration a parallel rise of the investigated values does not occur (i.e. number of leucocytes, body temperature, pulse, systolic and diastolic pressure, blood sugar level), the maximum values do not reach the levels of the control group, their rise is retarded, persists twice as long as in the control group and does not return to baseline values in the appropriate time. A pathological constellation of responses was recorded in 85.71% of the cases. A similar trend of changes was found also in a group of arteriosclerotic and hypertonic patients although in a lower percentage. The results confirmed the assumption that in the mechanism of reduced glucose tolerance in the periphery an important part is played by the impaired function of regulating centres in the diencephalon.

Adult↗
PubMed1989

[Vascular headache. Changes in visual evoked potentials].

The authors examined visual evoked potentials using the method of the visual full field stimulation hemi-field, using a check-board patterned structural stimulus in 69 patients with the diagnosis of vascular headache. The peak latencies of the waves did not differ significantly in the group of patients with vascular cephalea, as compared with the control group; this applies to both ways of stimulation. The es amplitudes of waves (P1 = P100 and N2) were significantly higher in the group with vascular cephalea after stimulation by the visual field. Of half the visual field stimulation did not reveal statistically significant differences in the latencies waves. The results may indicate an increased electrophysiological activity of the visual system in the interparoxysmal period in patients with vascular cephalea.

Adult↗
PubMed1989

[The new hemorheologic drug VULM 957 improves cerebral circulation].

The authors investigated the effect of a newly synthetized haemorheological drug VULM 957 for basic haemorheological parameters in vitro and on the cerebral flow in vivo. It was revealed that substance VULM 957 inhibits in a dose-dependent and time-dependent way the platelet aggregation, reduces the viscosity of blood, increases the deformability of red blood cells and increases the cerebral blood flow. Analysis of possible mechanisms of action of VULM 957 indicates that the observed positive haemorheological effects are due to the influence on the fluidity of the platelet and red cell membrane. The increased cerebral blood flow after administration of VULM 957 depends obviously on the reduced viscosity of the blood and the inhibited formation of platelet microaggregates. The presented results justify the assumption that VULM is a perspective substance in the therapy of cerebrovascular diseases.

Amines↗
PubMed1989

[Changes in glucose metabolism before and after the onset of focal cerebral ischemia. II. Production of insulin].

The purpose of the work was to assess the insulin secretion after a glucose load in a group of patients with cerebral infarction and in a group of arteriosclerotic and hypertonic patients, i.e. potential candidates of cerebral infarction. The material comprised 46 patients, incl. 29 with focal cerebral ischaemia and 17 with arteriosclerosis and hypertension. After oral glucose administration plasma insulin was assessed by radiooimmuncassay (IRI). It was revealed that insulinsecretion in the group of hypertonic and arteriosclerotic patients follows the rise of the blood sugar level, the rise is somewhat lower than in the control group but persists longer and returns later to baseline values. Similar but quantitatively more marked changes were refealed also in the group with focal cerebral ischaemia. From the results ensues that a reduced glucose tolerance in patients with cerebral infarction recorded in previous work is not due to an inadequate insulin secretion, i.e. the peripheral glucose metabolism, but indicates rather the ineffectiveness of insulin to restore glucose homeostasis.

Cerebral Infarction↗