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D Bastian

Publications and source records attributed to D Bastian.

32 records · Page 2Linked to original sources
PubMed1978

[Functional anatomy of a completely ossified hyoid apparatus in man. Study with cineradiography].

Radiocinematographic study of the laryngo-pharyngeal area in a man showing an entirely ossified hyoid system, made during the course of chewing, swallowing, and sound utterance. Two facts seem noteworthy: 1) from the morphological point of view, we should search in organogenesis for an explanation of the ossification of the hyoid apparatus; 2) from the functional point of view, one notes considerably reduced movements of the bone, without any change in the swallowing, or in the speach functions.

Cineradiography↗
PubMedDate not supplied

[Cemented versus cementless revision femoral stems using morselized allograft--a prospective, randomized study with 5 years follow-up].

BACKGROUND: There are only few studies on hip revision using the impaction grafting technique. Furthermore, data on cementless femoral stems as compared to cemented and polished femoral stems are lacking. We wanted to determine whether cementless femoral stems were equally good in preserving bone mineral density around the femoral stem and in functional outcome. METHOD: Consecutively 14 patients needing hip revisions for aseptic loosening in the stem with bone stock deficiency Paparowsky grade II were randomized into two groups intraoperatively. Morselized fresh-frozen bone allografts were impacted in both groups. The cemented group received polished Landos Fjord-CrCo stems and the uncemented group received the hydroxyapatite-coated Landos Corail-Titan stems. The dual energy X-ray absorptiometry was used to measure bone mineral density around the femoral stem according to Gruen zones. Function was measured by Merle d'Aubigné score. Patients were controlled at 0.5, 3, 6, 9, 12, 18, 24, 36 and 60 months postoperatively. RESULTS: There was no statistical difference between the BMD loss in the cemented vs. the uncemented group. The BMD loss was between 0-10 % in distal Gruen zones and was between 10-20 % in proximal Gruen zones. Functional scores were similar and reached a plateau of 16 in the Merle d'Aubigné score after 6 months. CONCLUSIONS: Cemented technique in hip revisions using morselized bone allograft is as good as uncemented technique in preserving BMD measured by the DEXA method and restoring function in a 5 years follow-up.

Absorptiometry, Photon↗
PubMedDate not supplied

Analysis of beta-catenin gene mutations in pancreatic tumors.

BACKGROUND/AIM: Mutations of the adenomatous polyposis coli (APC) tumor suppressor gene have been described in a subset of pancreatic carcinomas. The APC gene modulates the beta-catenin-Tcf pathway. The major player in this pathway is the beta-catenin protein encoded by the beta-catenin gene. A variety of different tumors, including colon, prostate, endometrial, and hepatocellular carcinomas, carry mutations in exon 3 of the beta-catenin gene. The aim of this study was to determine the role of the beta-catenin gene in the genesis of exocrine and endocrine tumors of the pancreas. METHODS: 78 ductal pancreatic adenocarcinomas, 14 ductal pancreatic cancer cell lines, and 33 endocrine pancreatic tumors were evaluated for mutations in exon 3 of the beta-catenin gene by single-strand conformation polymorphism analysis and direct DNA sequencing. In addition, 40 ductal pancreatic adenocarcinomas were analyzed for intracellular beta-catenin accumulation by immunohistochemistry, indicating alterations of the beta-catenin gene. RESULTS: Neither the 111 exocrine and endocrine pancreatic tumors nor the 14 pancreatic cancer cell lines carried mutations in exon 3 of the beta-catenin gene. Intracellular beta-catenin accumulation was not identified in any of the 40 pancreatic adenocarcinomas. CONCLUSION: These data suggest that the beta-catenin gene as the major player of the beta-catenin-Tcf pathway does not play an important role in the genesis of pancreatic tumors.

Adenocarcinoma↗
PubMedDate not supplied

[Leiomyomas of the duodenum (author's transl)].

The authors report a case of leiomyoma of the second part of the duodenum and note in the light of 55 cases in the literature, the main characteristics of this tumour including digestive hemorrhage, especially melena, which is the commonest mode of presentation. They compare it with other muscle tumours, e.g. sarcoma and myoid tumours. A barium meal and eventually superior mesenteric arteriography are the two main aids in diagnosis which remains by chance in 15% of cases. The volume of the tumour, the intimacy of its relations with the bile ducts influence the choice of surgery. The risk of hemorrhage and the histological uncertainty almost always lead to surgical operation.

Adult↗