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Biomedical subjects

D Beloica

Publications and source records attributed to D Beloica.

8 recordsLinked to original sources
PubMed1989

Influence of age and immunization on development of gingivitis in rats.

To study the effect of age and antigenic priming on the development of gingivitis, 33 healthy rats were placed in contact with Streptococcus mutans, Actinomyces viscosus, Fusobacterium nucleatum, and Bacteroides gingivalis. On days 0, 3, 7, and 14 after inoculation, the gingival condition was judged clinically and histologically, and serum antibody titers against the bacteria were measured. The rats were divided into three groups: 1 month old, 3 months old, and 3 months old immunized. None of the young rats developed gingivitis during the experiment, whereas half of the adult and all of the adult immunized rats bled on probing on days 7 and 14. In general, antibody titers against the bacteria were low in young rats, moderate in adult rats, and high in adult immunized rats. These results indicate that adult rats react stronger to plaque antigens than young rats and that previous contact with the antigens increases the reaction.

Actinomyces↗
PubMedDate not supplied

[Prenatal caries prophylaxis with fluoride tablets].

The attitude towards the use of fluoride tablets during pregnancy differs considerably: from absolute denying to assertion of obligate fluoride intake, even in higher doses than recommended. On the basis of our shides as well as of studies of other authors of pathohistologic, chemical and epidemiologic placental permeability of fluorides and of the influence of fluorides on the hard teeth tissues formed during the pregnancy, it can be concluded that: Fluoride application during pregnancy is a positive method since the effect of caries reduction in deciduous and permanent dentition has been confirmed; Tablets should be used from the 10the or 12the week of pregnancy; Tablets should be taken 30 minutes before the meal and an hour and a half before the intake of calcium tablets; The optimal daily dose for a pregnant woman is 1 mg of fluoride.

Dental Caries↗
PubMedDate not supplied

[Relation between plaque index and gingival cell infiltrate in experimental animals].

The aim of this study was to determine the relation between plaque and gingival cell infiltrates in highly imbreaded laboratory rats during experimentally provoked gingivitis. In this experiment 24 Lewis rats, aged 1-3 months, were used. From the zero day of inflammation plaque was scored by Sillnes and Löe index, while the presence of gingival cell infiltrate was determined with the stereological method. The results point out that the elder animals manifested early plaque accumulation, while the young group of animals presented a more intensive gingival cell infiltration. On the basis of the obtained results it can be concluded that within the equal amounts of plaque the young animals had a more intensive gingival cell infiltration as the result of distincet defensive reaction to the presence of microbial antigens.

Age Factors↗