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Biomedical subjects

D Bennett

Publications and source records attributed to D Bennett.

At least 307 records · Page 17Linked to original sources
PubMed1980

Bullous autoimmune skin disease in the dog: (1) clinical and pathological assessment.

The clinical and pathological findings of two cases of pemphigus vulgaris and four cases of bullous pemphigoid in the dog are reported. Clinically these cases were typified by ulcerative lesions of the oral mucous membranes, mucocutaneous junctions and skin. Pathologically there were intraepithelial separation and bulla formation in one of the cases of pemphigus and subepithelial separation and bulla formation in all cases of pemphigoid.

Animals↗
PubMed1980

Induction of tolerance in vitro by autologous murine testicular cells.

We have investigated the regulation of self tolerance in mice by examining lymphocyte reactivity in vitro against two subpopulations of autologous testicular cells: germ cells that were derived from the seminiferous tubules, and interstitial somatic cells. In the presence of germ cells, lymphocyte proliferation was strongly reduced. In contrast, somatic interstitial cells stimulated lymphocyte proliferation. In both cases, reactive lymphocytes were mostly T cells. Suppressor T cells activated by autologous germ cells were nonspecific and capable of inhibiting lymphocyte proliferation against autologous and allogeneic somatic testicular cells as well as against allogeneic spleen cells. Suppression was abrogated after treatment of the responder lymphocytes with anti-Ly-2.2 serum plus complement. Lymphocyte proliferation by autologous interstitial cells was considerably reduced, but not completely abolished, by complement-dependent lysis with anti-Thy-1.2 serum. This may indicate the participation in proliferation of a lymphoid cell population other than T cells.

Animals↗
PubMed1980

Nature of the antigenic determinants of T locus antigens.

The nature of the antigenic specificities of several antigens associated with the T/t complex in the mouse were analyzed by means of glycosidase and haptene inhibition studies. Results indicate that on testicular cells sugar residues are involved in at least six different T/t antigenic determinants. The immunodominant sugar appears to be different for each of the specificities. The specificity for the following T/t antigens resides predominantly in the sugars indicated: T:sialic acid; t12:beta-D-galactose; tw32:beta-D-galactose; t0:L-fucose; tw1:N-acetyl-D-galactosamine; tw18:L-fucose. It seems probable that these sugars are found at the terminal reducing ends of the carbohydrate portion of T/t-bearing moleculse. These studies imply that at least some of the genes in the T locus code for glycosyltransferases or regulators of glycosyltransferases which modigy oligosaccharide structures and impart specificity to the T/t antigens by alteration of their terminal sugar residues.

Acetylgalactosamine↗
PubMed1980

Smoking policies and smoking cessation programs of large employers in Massachusetts.

To assess the current extent of programs and policies to facilitate smoking cessation among employees, we queried 128 large employers in Massachusetts in mid-1978. Eighty-four (66 per cent) responded. Fifty-four (64 per cent) of the respondents had designated jobs or work areas in which smoking was prohibited usually because of potential danger to products or equipment. Seven (8 per cent) of the employers provided counseling, and 10 (12 percent) provided smoking cessation programs for those employees who desired to quit smoking. There is a clear need for the development and evaluation of workplace policies and programs aimed at reducing smoking.

Health Education↗
PubMed1980

In vitro development of inner cell masses isolated from t0/t0 and tW5/tW5 mouse embryos.

Inner cell masses (ICMs) isolated immunosurgically from mouse blastocysts segregating the homozygous lethal mutants t0/t0 and tW5/tW5 were cultured in vitro. Presumed t0/t0 ICMs fail to grow after three days in culture (equivalent gestational day 7.5) when they consist of an outer layer of endoderm cells surrounding about 30 epiblast cells. Presumed homozygous tW5/tW5 ICMs develop to a more advanced stage in culture and on the seventh day (equivalent gestational day 11.5) consist of an inner core of disorganized ectoderm cells with a small proamniotic cavity, surrounded by multiple layers of endoderm cells.

Animals↗
PubMed1979

A combined transcutaneous pulse-echo and Doppler ultrasonic technique for the measurement of brachial artery peak velocity.

The Parks Model 806 Doppler blood velocity meter was shown to have a linear voltage output with respect to input frequencies of up to 5kHz. It was linear and accurate to velocities of 70 cms-1 at angles of 50 degrees and 60 degrees to the flow, on a steady flow rig, and shown to have a linear frequency response to 9Hz. A combined pulse echo and Doppler transducer system has been developed allowing quantitation of arterial peak velocity.

Blood Flow Velocity↗