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D Bernardini

Publications and source records attributed to D Bernardini.

33 records · Page 2Linked to original sources
PubMed1995

[Treatment of caustic stenoses of the upper digestive tract].

Stenosis of the upper digestive tract developed in 22 patients with stage IIB or stage III caustic burns due to massive ingestion of an alkaline substance in 18 cases and an acid substance in 4 cases is analysed. Emergency oesogastrectomy without thoracotomy was performed in emergency situations in 10 patients in whom mortality reached 30%. For the remaining 12 patients with minimal stage IIB lesions, a jejunostomy was opened for enteral nutrition. After three months, stenosis developed in 10 cases and required surgical treatment in 7 after failure of endoscopic dilatations. Surgery included retrosternal coloplasy with oesophagectomy for 3 patients. There were no deaths. Two patients with a stenosis of the cervical anastomosis were treated endoscopically. These results suggest that the use of the endoscope in the acute phase can help ascertain the best management technique and confirms that stage IIB stenosis can develop a tight stenosis in 50% of the cases. This situation requires surgical treatment in 70% of the cases.

Adult↗
PubMed1977

[The determination of amanitines in the serum of patients poisoned by amanita phalloides (author's transl)].

The serum of patients suffering from Amanita phalloides poisoning was analysed in order to determine whether amanitines, which are the principal toxins of this fungus, were still present in the blood at the time of hospitalisation. In addition, the authors measured the concentrations of amanitines in the blood of dogs at different intervals after the ingestion of a fatal dose of Amanita phalloides. Amanitines were detected in the serum of 9 patients out of 16. This discovery, together with the finding that, in the dog, very low concentrations of amanitines in the blood are associated with fatal cellular lesions, suggests the need for very prompt action in order to eliminate these toxins from the blood as soon as the diagnosis of poisoning is suspected.

Amanita↗
PubMedDate not supplied

Beta-2-microglobulin and Helicobacter pylori infection in uraemic dialysed patients.

Chronic gastritis in patients with chronic renal failure may have different causes and mechanisms. Recent observations suggest that severe gastritis often found in uraemic patients might be related to Helicobacter pylori (HP) infection. In chronic gastritis HP has been found in the mucus and on the epithelial cell surface of gastric foveolas. Significant infiltration of the subepithelial gastric layer by polymorphonuclear leucocytes has been described. Moreover, beta-2-microglobulin deposits have been found by immunohistochemical methods in the subepithelial layer of gastric mucosa of uraemic dialysed patients with active chronic gastritis and HP infection. Similar findings have also been demonstrated in gastric biopsies from patients with HP positive active chronic gastritis and normal renal function. Since HP infection is associated with significant leucocyte infiltration, it is hypothesized that the inflammatory process causes the release of beta-2-M from the surface of the leucocytes and its subsequent deposition at gastric level.

Adult↗
PubMedDate not supplied

[Studies on the conidial differentiation of "Neurospora crassa" -- VII. -- Alcoholic regulation and conidiogenous capacity (wild-type and "fluffy" mutant) (authors transl)].

Sucrose consumption by the wild-type Neurospora crassa is quicker, with much more ethanol produced, in the ammonium medium than in nitrate as single N source. On low sugar concentration which is quickly nullified, little alcohol is produced and early conidiation can develop. The higher the initial sugar concentration, the higher is the alcoholigenic coefficient defined as the efficiency of alcoholic glycolysis per unit of sugar consumed, and the more complete is the conidial "repression" in ammonium medium. The nitrate counteracts this catabolic repression effect and, depressing the alcoholigenic coefficients, permits conidiation even on high sugar (8 %) medium. The "fluffy" mutant produces relatively less ethanol (average 2-3 times less) in all cases even though it increases its alcoholigenic coefficient with the increased sugar concentration. Surprisingly, it is not induced to alcoholigenic glycolytic disinhibition by ammonium and produces even more alcohol in nitrate than in ammonium media, thus revealing an inability to benefit from the antiglycolytic, normally conidiogenous, effect of nitrate. Suggestion is made that this amacroconidial mutant is defective in its metabolic regulation related to the Pasteur effect which is required for conidiogenic expression in the wild type.

Cell Differentiation↗
PubMedDate not supplied

[Gastroesophageal reflux update].

Authors describe importance of anatomical and functional factors in ethiopatogenesis of G.E.R., diagnostic iter and methods. Importance of 24-hour computerized pH-metry in pediatric age is particularly stressed out. Medical and surgical therapeutic procedures are emphasized.

Antacids↗