PubMed Health⌕ Search

Biomedical subjects

D Bessis

Publications and source records attributed to D Bessis.

At least 37 records · Page 2Linked to original sources
PubMed1996

Granulomatous mycosis fungoides presenting as sarcoidosis.

This report describes the case of a woman who developed cutaneous granulomatous infiltration during childhood that was initially considered to be sarcoidosis and, after 27 years of evolution, was determined to be caused by granulomatous mycosis fungoides transforming to Ki-1-positive anaplastic large-cell lymphoma of T-cell type. We discuss the differential diagnosis, especially granulomatous slack skin and the interest of immunohistochemical and genotypic studies in this case.

Adult↗
PubMed1995

Antiphospholipid antibody production during Mediterranean spotted fever.

Antiphospholipid antibodies (aPLA) were discovered during the course of Mediterranean spotted fever (MSF) caused by Rickettsia conorii and characterized by endothelial cell (EC) damage resulting from this organism's tropism for EC. In two MSF patients, two types of aPLA were identified: antiphosphatidylethanolamine antibodies detected by immunological methods and lupus anticoagulant detected by clotting assays. The persistence of both aPLA for several months after the acute phase and clinical recovery might correspond to a durable immunological response to membrane damage of EC caused by R. conorii. Their possible role in the pathophysiology of microthrombi formation observed during MSF remains to be elucidated in a study on a larger number of patients.

Antibodies, Anticardiolipin↗
PubMed1994

[Syndrome of hemophagocytosis associated with infections].

Infection-related hemophagocytic syndrome was originally described in viral processes by Risdall in 1979. Recent reports have suggested associations of this syndrome with bacterial, parasitic and fungal infections. It occurs generally in immunosuppressed patients. The clinical and biological manifestations are not specific. The diagnosis is based on morphologic examination of the bone marrow showing a benign proliferation of histiocytes with hemophagocytosis. Treatment is symptomatic, however when an infectious etiology is found a specific treatment must be applied. This pathology has a poor prognosis, with a fifty percent mortality rate. When evolution is favorable, relapses are exceptional. The precise pathophysiological mechanism has not yet been determined. A better understanding of the cytokines' role should permit to consider new therapeutic routes.

Adolescent↗
PubMed1993

[Phakomatosis pigmento-vascularis. Report of 2 cases associated with angiodysplasia].

Phakomatosis pigmentovascularis is an uncommon disease, with a peculiar association of capillary hemangioma and pigmented lesions. Four entities have to date been described (I to IV), with localized (a) or systematical (b) involvement. In this latter subtype, the cutaneous lesions are associated with visceral (eye, central nervous system) and bony abnormalities. We describe two additional cases of phakomatosis pigmentovascularis type II (b) associated with a Klippel-Trenaunay syndrome. These reports emphasize the frequent occurrence of angiodysplasia of the Klippel-Trenaunay or Sturge-Weber-Krabbe type in the systemic subtype, especially II (b). Accordingly, complete investigations are warranted in all cases, with special attention for bones and some internal organs like eye and central nervous system. Pathophysiological hypothesis for phakomatosis pigmentovascularis are discussed.

Adult↗