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D Blake

Publications and source records attributed to D Blake.

100 records · Page 6Linked to original sources
PubMed1979

Transrectal ultrasonography in the evaluation of cervical carcinoma.

Transrectal ultrasonography has proved useful in the evaluation of genitourinary disease. Experience with prostate scans has shown that such conditions as prostate carcinoma and benign prostatic hyperplasia can be diagnosed and assessed with a high degree of accuracy. In patients with carcinoma of the bladder this method is useful in determining the degree of tumor invasion within the bladder wall. Our experience with scans of the uterus is in its early stages. We have studied 30 patients with documented cervical carcinoma and are studying 1) the presence and extent of parametrial involvement, 2) the ability to distinguish benign from malignant lesions, and 3) the identification of bladder invasion.

Adult↗
PubMed1978

Radiation therapy in the treatment of superior vena caval obstruction.

The obstruction of the superior vena cava by tumor is recognized as an acute or subacute oncologic emergency. Rapid high-dose irradiation to the mediastinum is shown to be effective therapy for a superior vena caval obstruction. In our series 35 patients have been treated with rapid high-dose irradiation between January 1971 and July 1977. The present treatment consists of 400 rad given in a daily midplane dose for 3 days, and then slowing to 150 rad midplane per day to a total dose of 3000 rad over 15 fractions. There have been no instances of exacerbations of symptoms or severe complications from this treatment. There have been 2 failures of the 35 patients treated with this regimen. Both were shown at autopsy to have massive thrombi obstructing the superior vena cava. Six years of experience using this regimen has proven to be a safe and effective means of treatment for superior vena caval obstruction.

Adult↗
PubMed1976

Response of superior vena cava syndrome to radiation therapy.

The treatment of a superior vena caval obstruction associated with a mediastinal mass is a true radiotherapeutic emergency. The heralding signs and symptoms and the morbidity of the syndrome justify beginning therapy before a pathologic diagnosis is established. In a series of 19 patients with superior vena cava syndrome, there was an excellent response to an initial high-dose course of irradiation, consisting of 400 rads midplane for 3 days, then reduced to conventional daily fractionation. It is concluded that rapid high-dose irradiation in the treatment of a superior vena cava syndrome is safe and effective.

Adult↗
PubMedDate not supplied

Haem in the gut. Part II. Faecal excretion of haem and haem-derived porphyrins and their detection.

Only a fraction of haem (ferroprotoporphyrin) finding its way into the gut lumen is absorbed; the major portion enters the colon. There, unabsorbed haem, together with any haem of haemoproteins shed directly into the colonic lumen as haemoglobin or other haemoproteins, are converted by bacteria to a range of haem-derived porphyrins (HDP) lacking iron. This conversion is a slow and incomplete process and the amount converted in this way depends on colonic transit rate, site of bleeding and amount of luminal haem. As a consequence, faeces contain variable proportions of haem and HDP. The guaiac and tetramethylbenzidine tests give a qualitative index of faecal blood; they depend on the pseudoperoxidase activity of intact haem and cannot detect HDP. These tests perform better for large bowel bleeding than for more proximal bleeding. The fluorimetric HemoQuant assay quantitates both haem and HDP; it performs well for both proximal and distal bleeding. Neither type of test can allow for intestinal absorption of haem or HDP. Quantitation of gastrointestinal bleeding derived from measurement of faecally excreted haem and HDP is, therefore, likely to underestimate haem delivered into the gut lumen. In a given clinical situation, the choice of a haem-dependent occult blood test must take into account the possibility of colonic conversion of haem to HDP and the possible value of quantitation as opposed to qualitative detection.

Colon↗