[Importance of changes in the oxygen transport of the blood in clinical medicine, with special reference to neonatology].
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Biomedical subjects
Publications and source records attributed to D Boda.
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A study was made of the effect of a 3-hour incubation with inosine-pyruvate-phosphate (IPP) on the P50 values and 2,3-DPG contents of fresh blood and blood which had stood for 96 h, from healthy adults, term neonates, 1-2-week-old symptom-free premature infants and RDS premature infants. It was found that the P50 value and the 2,3-DPG content could be increased considerably by IPP treatment in both the fresh and the stood blood in the various groups of neonates. The question remains open as to whether the effect of IPP, in significantly improving the O2 transport in neonates, is a consequence of the 2,3-DPG alone or of some other metabolite. In RDS the stimulating effect of the IPP mixture is appreciably lower.
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The biological value of heparinized blood was found to decrease less on storage at 0 degrees C than on storage at +4 degrees C. At 0 degrees C the P50 value decreases substantially later and less, the blood is less acidotic, and the UV absorption of the dialysate is less enhanced than at +4 degrees C. The findings justify a further search for the conditions suitable for the widespread practical application of storage at 0 degrees C.
In 16 chronically dialysed uraemic patients in the course of altogether 61 treatments with the artificial kidney the UV-absorption spectre of the in-vitro-dialysate of the serum was studied. In uraemia on account of the retention of the metabolic products the UV-absorption spectre of the serum dialysate is extremely increased, a decrease is to be registered after the dialysis. The method discussed is suitable for the control of the effectiveness of haemodialysis and gives a more complex picture concerning the changes during the treatment than the usual laboratory parameters.
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