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Biomedical subjects

D Bono

Publications and source records attributed to D Bono.

24 records · Page 2Linked to original sources
PubMed1989

Respiratory mechanics in anesthetized paralyzed humans: effects of flow, volume, and time.

The effects of inspiratory flow rate and inflation volume on the resistive properties of the total respiratory system were investigated in 16 anesthetized paralyzed humans by using the technique of rapid airway occlusion during constant flow inflation. This allowed measurement of the intrinsic resistance (Rmin,rs) and of the effective additional resistance (delta Rrs) as the result of viscoelastic pressure dissipations within the pulmonary and chest wall tissues. We observed that 1) at fixed inflation volume, Rmin,rs increased linearly with increasing flow although delta Rrs decreased according to an exponential function; 2) at fixed inflation flow, Rmin,rs decreased with increasing inflation volume although there was a concomitant increase in delta Rrs. This behavior could be explained in terms of a spring-and-dashpot model incorporating 1) the standard resistance and elastance and 2) a spring-and-dashpot in parallel with standard elastance, reflecting the stress adaptation units within the thoracic tissues.

Adolescent↗
PubMedDate not supplied

[Neuroleptic malignant syndrome. Problems of differential diagnosis. Description of a clinical case].

Neuroleptic malignant syndrome (NMS) in its most severe form ranging from disorders of consciousness to coma is now reported relatively frequently in intensive care journals. Having observed such a case in the intensive care ward of their hospital, the Authors investigate the possibility of differential diagnosis between this syndrome and other prevalently psychiatric and non-psychiatric types. It is underlined that the diagnosis of NMS is not straightforward taking into account both the type of patients who are mainly affected, that is to say psychopathic subjects undergoing prolonged therapy with heavy tranquillisers, in poor general condition, sometimes abandoned and then found in coma, and the fact that some psychiatric syndromes or drug overdoses may led to similar symptoms but require completely different treatment.

Adult↗