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Biomedical subjects

D Bousseau

Publications and source records attributed to D Bousseau.

10 recordsLinked to original sources
PubMed1987

Decreased incidence of supraventricular arrhythmias achieved by selective atrial cooling during aortic valve replacement.

Inadequate atrial hypothermia and subsequent ischemic injury have been recognized as the major causes of supraventricular arrhythmias (SVAs) and conduction defects following cold chemical cardioplegia. This study was designed to assess the effects of right atrial cooling (15 degrees-20 degrees C) during cardioplegic arrest upon the incidence of postoperative SVAs and conduction defects in 40 consecutive patients undergoing isolated aortic valve replacement. Atrial preservation was ensured by combining systemic (24 degrees C) and topical hypothermia with snared double caval cannulation during arrest. Myocardial temperatures in the right atrial septum and anterior wall of the right ventricle were recorded before and after each cardioplegic infusion and upon release of caval tapes. Postoperatively, the incidence of SVAs and conduction defects was assessed by continuous rhythm monitoring, bipolar atrial electrograms and, in ten patients, 24-h Holter recordings during the first postoperative day. With the venae cavae snared, temperatures in the right atrial septum were not significantly different from those measured simultaneously in the right ventricle. Release of caval tapes resulted in right atrial temperatures increasing to systemic temperature (from 17.1 +/- 2.9 degrees C to 25.9 +/- 5.6 degrees C [m +/- SD]; P less than 0.01). Atrial rewarming between cardioplegic infusions did not exceed 2.9 degrees +/- 3.2 degrees C. Postoperatively, four patients (10%) developed sustained atrial fibrillation. One additional patient had a single episode of paroxysmal atrial fibrillation and two patients experienced asymptomatic episodes of junctional rhythm.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1987

Left ventricular global and regional function during lumbar epidural anesthesia in patients with and without angina pectoris. Influence of volume loading.

The influence of lumbar epidural anesthesia without cardiac sympathectomy on global and regional left ventricular function was investigated prior to surgery in eight normal subjects (group 1) and in ten patients suffering from stable mild effort-related angina (group 2). In both groups, epidural blockade was performed with 10 ml 0.5% plain bupivacaine. To differentiate the effects due to epidural blockade from those related to volume expansion, three sets of measurements were obtained: control, epidural blockade without volume loading, and epidural blockade with volume loading (500 ml lactated Ringer's solution). Radionuclide angiography was used to determine cardiac output, left ventricular ejection fraction, end systolic and end diastolic volumes, and to analyse left ventricular wall motion. Peak systolic pressure-end systolic volume ratio was used as an index of myocardial contractility. Seventy-two hours postoperatively, a thallium 201 myocardial scintigraphy obtained after iv dipyridamole detected myocardial defects in all patients with a history of angina. These defects were fully redistributed in eight out of ten patients. Throughout the procedure, patients with a history of angina exhibited neither chest pain nor ECG evidence of myocardial ischemia. At control, left ventricular ejection fraction (LVEF) and systolic pressure-volume ratio (SPVR) were lower in group 2 than in group 1 (LVEF: 0.54 +/- 0.02 vs. 0.64 +/- 0.02, P less than 0.01), (SPVR: 2.3 +/- 0.2 vs. 3.3 +/- 0.4 mmHg/ml, P less than 0.05). In addition, 19 hypokinetic sectors were found in group 2.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1986

Response of left ventricular ejection fraction to recovery from general anesthesia: measurement by gated radionuclide angiography.

To test the hypothesis that, after anesthesia for noncardiac surgical procedures, the increased cardiac work during recovery induces wall motion and ejection fraction (EF) abnormalities in patients with mild angina pectoris, gated radionuclide angiography was performed in patients undergoing simple cholecystectomy under narcotic-relaxant general anesthesia. The ejection fraction was determined during anesthesia at the end of surgery, and then determined 3 min and 3 hr after extubation. A new angiography was performed 24 hr later, and a myocardial scintigraphy (Thallium 201) was performed during infusion of the coronary vasodilator, dipyridamole. In the first part of the investigation, eight patients without coronary artery disease (CAD) (group 1) and 20 patients with mild angina (group 2) were studied. In the second part of the study, seven patients (group 3) with mild angina pectoris received an intravenous infusion of 0.4 microgram X kg-1 X min-1 of nitroglycerin started before surgery and gradually decreased 4 hr after extubation. In group 1, EF remained unchanged at recovery. In contrast in group 2, EF responded abnormally to recovery: EF decreased from 55% during anesthesia to 45% 3 min after extubation (P less than 0.001). Patients in group 3, who received intravenous nitroglycerin, showed no change of EF at recovery. This study demonstrates that recovery from general anesthesia causes abnormalities in left ventricular function in patients suffering from CAD. These abnormalities are prevented by prophylactic intravenous nitroglycerin.

Aged↗
PubMed1986

Comparison of perioperative and postoperative phasic blood flow in aortocoronary venous bypass grafts by means of pulsed Doppler echocardiography with implantable microprobes.

Although graft dimension and hemodynamic variables have been suggested as important determinants of the functional results of aortocoronary bypass grafting, there is no easy-to-use bedside method of monitoring phasic blood flow in coronary bypass grafts. We developed a miniaturized implantable silicone pulsed Doppler flow probe linked to a classic 8 MHz pulsed Doppler system. This apparatus has an adjustable range-gated time system that permits accurate measurement of diameter (D, in mm), cross-sectional blood flow velocity (Vm, in cm/sec), and coronary bypass graft flow (CBGF, in ml/min) as pi D2/4 X Vm X 60. Ten patients (55 +/- 7.2 years SD) with preoperative left ventricular ejection fractions over 45% received the implantable flow probes during the aortocoronary venous bypass procedure. Closure of the chest altered systolic and diastolic components of flow velocity and CBGF decreased from 131 +/- 65.8 to 94 +/- 55 ml/min (-28%; p less than .01). Comparison between early postoperative values (intensive care unit) and values 6 days later showed significant increases in diameter from 4.2 +/- 0.9 to 5.3 +/- 0.9 mm (p less than .01) and in CBGF from 130 +/- 112 to 204 +/- 86 ml/min (p less than .01). We conclude that the implantable pulsed Doppler microprobe is a sensitive bedside method for monitoring aortocoronary bypass graft diameter and blood flow in the postoperative period.

Blood Flow Velocity↗
PubMed1985

[Fatal hypoxemia following extracorporeal circulation for aortocoronary bypass. A case].

A lethal case of acute respiratory distress syndrome of the adult following extracorporeal circulation for aorto-coronary bypass is reported. This case illustrates the two mechanisms currently thought to be responsible for this pathology: (1) the passage of blood over the synthetic fibres of the cardiopulmonary bypass machine activates the complement, and the systemic inflammatory reaction that ensues accounts for the increased permeability of the alveolar capillary membrane; (2) the haemodilution inherent in extracorporeal circulation explains the hypoproteinaemia usually observed at the end of the procedure; the resulting fall in capillary osmotic pressure upsets the equilibrium of pressures in the capillary vessels.

Coronary Artery Bypass↗
PubMed1985

Left ventricular dysfunction after non-cardiac surgical procedures in patients with ischemic heart disease.

In order to demonstrate the presence of postischemic ventricular dysfunction after non-cardiac surgical procedures, myocardial perfusion scintigraphy with thallium 201 and radionuclide ventriculography were performed before and 24 h after intervention in 20 patients suffering from angina pectoris. A long-term ECG recording was used in all patients to detect peroperative myocardial ischemia. In 14 of the 20 patients studied, both ventriculography and thallium scintigraphy were unchanged at the postoperative study. Comparison of pre- and postoperative radionuclide data revealed an increased deficit in one patient, both increased deficit and decreased ejection fraction in four others and a decreased ejection fraction in one other. In these five last patients, continuous ECG recording demonstrated the occurrence of peroperative ST segment depression. These results underline the part played by prolonged peroperative episodes of myocardial ischemia in the occurrence of postoperative left ventricular dysfunction.

Adult↗
PubMed1984

[Complement activation during extracorporeal circulation. A model for understanding lesional pulmonary edema].

The complement system (CH50, C3, C4, C3 PA) was monitored during extra-corporeal circulation in 10 patients with ischemic-heart disease. Mean concentrations of CH50, C3, C4, and C3 PA significantly decreased as early as 5 minutes after initiation of the extra-corporeal circulation and decrement remain steady all over the surgical procedure. Transient neutropenia occurred early during the procedure. A significant hypoxemia was present only 24 hours after surgery. We suggest that a complement mediated leukostasis might occur with sequestration in the lungs and contribute to endothelial cell damage with pulmonary edema known as the "post-pump syndrome".

Adult↗