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Biomedical subjects

D Bracchetti

Publications and source records attributed to D Bracchetti.

At least 73 records · Page 4Linked to original sources
PubMed1980

Effect of verapamil on ST-segment elevation evaluated by the orthogonal leads of the Frank vector system in patients with acute myocardial infarction.

The effect of i.v. verapamil (0.1 mg/kg) on myocardial ischemic injury was evaluated using the orthogonal leads of the Frank system in 10 selected patients with acute myocardial infarction admitted to the C.C.U. within 8 h from the onset of symptoms. The ST-vector magnitude (STVM) which remained stable over a 2-h control period was progressively and significantly reduced after verapamil administration (-21.1 +/- 5.3%, P < 0.02, 15 min after the injection; -36.5 +/- 6.8%, P < 0.01, after 120 min). Verapamil significantly lowered systemic blood pressure immediately after injection (from a mean value of 134 +/- 3/83 +/- 2 mmHg to 121 +/- 3/76 +/- 2 mmHg); the reduction of systolic blood pressure was effectively maintained through the whole experimental period, while heart rate and the product "heart rate x systolic blood pressure x 10(-3") were not significantly changed. The results are discussed in terms of a possible relationship between the reduction of STVM by verapamil and a reduction of the ischemic area.

Adult↗
PubMed1979

Evaluation of clinical efficacy and plasma levels of aprindine.

The clinical efficacy of Aprindine, a new antiarrhythmic agent was tested in 37 patients with ventricular and supraventricular arrhythmias. The drug was shown to be effective - disappearance or prevention of relapse of the arrhythmia - in 80% of the cases with ventricular tachycardia, and in 67.7% of the cases with premature ventricular beats. No judgement was possible for supraventricular tachycardia due to the small number of patients. Effectivness of Aprindine was found to be related more closely to the administered dose expressed in mg/kg body weight than to plasma level in steady-state. Discontinuation of therapy was necessary in 5 cases due to the appearance of side effects (tremor and dizziness). Side effects were not found to be in relation with plasma levels or administered dose. In the period of observation (2 months) no effects on blood cells were noticed.

Adult↗
PubMed1979

Comparison of hemodynamic effects induced by pentaformilgitoxin and deslanoside in patients with heart failure.

The effect of pentaformilgitoxin and deslanoside on heart rate, blood pressure and cardiac output was compared in six patients with heart failure. Pentaformilgitoxin caused an increase of cardiac output from 3361 ml/min to 4183 ml/min (p less than 0.01). Deslanoside induced a non significant increase of cardiac output from 3617 to 3848 ml/min. Heart rate decreased significantly by both drugs: the reduction was greater after deslanoside (from 93.7 to 77.5 beats/min) than after pentaformilgitoxin (from 92 to 85 beats/min). Both drugs caused a comparable increase in stroke volume.

Aged↗
PubMed1979

[Effects of acute infusion of verampil on the ST segment elevation measured with the Frank orthogonal leads in patients with acute myocardial infarct].

The effect of verapamil on ST changes was evaluated in 10 selected patients with acute myocardial infarction admitted to the Coronary Care Unit within 8 hours after the onset of symptoms. To evaluate the extent of ischemia it has been used the magnitude and direction of the ST vector derived from X, Y and Z leads of the Frank vector system. After a control period of 2 hours, during which the changes of the ST vector magnitude were assessed, each patient received 0.1 mg/Kg verapamil intravenously, ST vector magnitude (STVM), ST azimuth (STAZ), ST elevation (STEL), heart rate, systemic blood pressure and pressure-rate product were assessed 5, 15, 30, 45, 60, 75, 90, 105 and 120 minutes after the administration of the drug. Verapamil produced a significant progressive decrease in STVM (from a mean of 254 +/- 44 muV at the end of the control period, to 139 +/- 25 muV after 2 hours; P < 0.01). Systolic blood pressure decreased significantly throughout the trial; the most significant decrease was registered immediately after the infusion of verapamil (from a mean of 134 +/- 3 mmHg to 121 +/- 3 mmHg; P < 0.001). Pressure-rate product declined slightly. No significant change in STVM was observed in 10 control patients with acute myocardial infarction examined over a 4 hours period. The apparent protective effect of verapamil in myocardial ischemia is discussed in relation to its calcium-antagonistic properties in excitable tissues.

Adult↗
PubMed1977

[Electrocardiogram in pulmonary embolism].

The Authors are examining the electrogenetic and vectorial alterations during pulmonary embolism and the consequent more frequent electrocardiographic patterns according to the literature data. The analysis of the electrocardiograms of 37 patients with proved pulmonary embolism confirms that ECG is not of absolute diagnostic value but may be extremely useful especially if subsequent records are compared.

Electrocardiography↗