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Biomedical subjects

D Brunel

Publications and source records attributed to D Brunel.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[The E.E.G. and E.M.G. findings in sudanophilic leucodystrophy (author's transl)].

Four patients with infantile familial sudanophilic leucodystrophy confirmed histologically and biochemically were investigated by E.E.G. and E.M.G. The E.E.G. showed a severe, non-specific slow wave abnormality, of moderate voltage and disorganized in 2 cases, with some critical' tonic' discharge. E.M.G. study was normal in relaxed muscle; peripheral nerve stimulation, however, revealed marked slowing of motor conduction velocities favouring a segmental demyelinisation process, which was ultimately confirmed histologically. This study underlines the value of investigation of infantile encephalopathies.

Cerebral Cortex↗
PubMedDate not supplied

[Effect of dobutamine on the transport and consumption of oxygen during general anesthesia with enflurane].

We undertook a comparative study on the effects of dobutamine and placebo on hemodynamic parameters, O2 transport (DO2), O2 consumption (VO2, and acid lactic production during peripheral arterial surgery under general anesthesia with enflurane at a constant inspiratory concentration (1.2%). This study involved 18 patients older than 65 years (9 patients allocated in the dobutamine group and 9 in the placebo group). The hemodynamic course was monitorized by means of noninvasive methods such as the aortic output measured by continuous transoesophageal echo-Doppler. After introduction of enflurane into the circuit aortic output decreased by 39% in dopamine group and 36% in placebo. Total systemic vascular resistances increased by 52% in dopamine and by 48% in placebo treatment. DO2 showed a decrease of 39% in dopamine and 38% in placebo group. There were no appreciable differences in VO2 among the two groups. Recovery of hemodynamic parameters and DO2 was only observed in the dopamine group when the drug was perfused at a rate of 4 +/- 1.2 micrograms/kg/min. Dobutamine induced a transient increase of VO2 up to 225% of the baseline value. During the postanesthetic period VO2 and blood acid lactic were significantly higher in the dopamine than in the placebo group (192%, p less than 0.01 and 33%, p less than 0.05, respectively). The course of hemodynamic parameters, DO2, VO2, and blood acid lactic of dobutamine group appear to demonstrate that dobutamine perfusion reverts myocardial depression and improves cellular perfusion during general anesthesia with enflurane.

Aged↗
PubMedDate not supplied

[Use of diazepam in the preventive home treatment of recurrent febrile convulsions].

Parents with children who had presented with a simple febrile convulsion were advised to give their children rectal diazepam, in case of fever. The results (21 families with an average follow-up of 2 years) were compared with those in two groups of controls. The efficacy and inocuousness of prophylactic treatment are remarkable. However, its indication should be more precisely stated, after a better information of families and practitioners, since the expected effect on familial apprehension was not satisfactorily obtained.

Child↗
PubMedDate not supplied

[Role of Streptococcus group D in infections in newborn infants].

Our investigation concerns 14 streptococcus D sepsis neonates, thirteen of which were collected over a six year period during which eighty-two neonate infections were recorded. This rate slightly higher than generally recorded and may be due to the initial prescription of third generation cephalosporin to the mothers. The clinical, hematological and biological data are not specifically those of group D streptococcus. The issue was unfavourable in 15% of our cases and in 8 to 33% of the recorded cases. The sensitivity to antibiotics varies depending on the species of group D streptococcus. The effectiveness of Amoxicillin, of Mezlocillin and of Ampicillin justifies the initial prescription in association with an aminoglycoside because of the possibility of synergy; cephalosporins are contraindicated as they are inactive on this germ.

Anti-Bacterial Agents↗