Cutaneous manifestations of zinc deficiency during treatment with anticonvulsants.
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Biomedical subjects
Publications and source records attributed to D Bryce-Smith.
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The vanadium content of hair, whole blood, serum and urine was estimated by neutron activation analysis in samples from manic patients, depressed patients, recovered manic patients, recovered depressed patients and normal controls. The results suggest that manic patients have significantly raised vanadium levels in hair which fall towards control levels with recovery, but there are no significant differences in the mean vanadium content of whole blood or serum. In contrast, depressed patients have raised levels of vanadium in whole blood and serum which appear to fall with recovery. Levels of vanadium in serum correlate strongly with those in whole blood, but neither shows significant correlation with vanadium in hair for either patients or controls. Hair and blood probably serve as indicator tissues for differing aspects of vanadium metabolism.
Vanadium content of hair from manic patients, recovered patients, and normal controls was measured by neutron activation analysis. The mean vanadium content of the hair of the manic group was significantly higher than that of the control group and that of the group of recovered manics.
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The concentrations of 16 elements (Al, Ba, Br, Ca, Cl, Cu, I, Pb, Mg, Mn, Mo, Rb, Se, Na, S and Ti) were estimated by neutron activation analysis in samples of hair, whole blood, serum and urine from normal controls, from patients suffering from mania and depression and from patients who had recovered from mania and from depression. Significant differences between groups were shown but apart from molybdenum, no element showed a significant change in more than one tissue. The differences in molybdenum concentrations appear to be of potential interest but the results must be interpreted with caution.