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Biomedical subjects

D Buggy

Publications and source records attributed to D Buggy.

24 records · Page 2Linked to original sources
PubMed1993

Lipoprotein(a) and treatment of chronic renal disease.

OBJECTIVES: To compare lipoprotein(a) [Lp(a)] and albumin concentrations in patients with chronic renal disease receiving different forms of treatment and to determine, if any, the relationship between these variables. DESIGN: A prospective cross-sectional, case-controlled study. SETTING: A tertiary referral nephrology and dialysis unit. SUBJECTS: Forty-four consecutive non-diabetic patients with chronic renal failure treated by renal transplantation (n = 18), haemodialysis (n = 18), continuous ambulatory peritoneal dialysis (CAPD; n = 8), and 30 healthy controls from subjects drawn from University personnel were studied. INTERVENTIONS: Fasting morning venous blood was analysed for Lp(a), albumin, total cholesterol and glucose concentrations. MAIN OUTCOME MEASURES: Comparison of plasma levels of these variables between the sub-groups. RESULTS: Concentrations (median; 95% CI) of Lp(a) were significantly (P < 0.05) higher (38.4 mg dl-1; range 15.4-72.0) and of albumin lower (31.6 g l-1; range 28-35.2) in the CAPD group compared with both control subjects and other groups of chronic renal disease patients. CONCLUSIONS: The elevated Lp(a) concentrations seen only in association with reduced albumin concentrations in CAPD patients suggest a regulatory role for albumin with albumin losses stimulating production of Lp(a).

Adult↗
PubMed1993

Microalbuminuria and coronary heart disease in non-diabetics.

Microalbuminuria (or urinary albumin excretion rates (AER) above normal limits) is associated with coronary heart disease (CHD) particularly in diabetics. To determine the sensitivity and specificity of AER for CHD in a non-diabetic population we prospectively studied 115 consecutive patients undergoing coronary angiography and 66 undergoing exercise electrocardiography (ECG). There was no relationship between AER and the severity of CHD determined by angiography (Gensini-scored). While microalbuminuria (AER > 20 micrograms/minute) was 91% specific it had low sensitivity (12%). Microalbuminuria is not a sensitive indicator of CHD in a non-diabetic population.

Aged↗
PubMedDate not supplied

Patient attitudes to perioperative suppository administration for postoperative analgesia.

Four hundred surgical patients were questioned preoperatively to ascertain their attitudes to suppository analgesia. Given a choice, 82 per cent of patients expressed a preference for intramuscular administration of diclofenac, with 18 per cent choosing a suppository. Males were more likely than females to choose an intramuscular injection. Males choosing a suppository were more likely to belong to a higher socio-economic group while females choosing a suppository were more likely to be married. Twenty-three per cent of patients who initially opted for intramuscular administration changed to suppository administration when the possibility of pain or discomfort at the injection site was explained. Females who changed to suppository administration were more likely to belong to a higher socio-economic group and to be married. Twenty-seven per cent of patients choosing an intramuscular injection expressed concern if a suppository were to be inserted without consent. Eleven per cent of patients choosing a suppository expressed similar concern. There is an overall reluctance, particularly within the male population to accept suppository analgesia. Patients from higher socio-economic groups may be more willing to accept what they perceive to be less traditional forms of treatment.

Analgesia↗
PubMedDate not supplied

Acute inhibitory effect of alcohol on sodium-lithium countertransport.

To assess a possible acute effect of environmental factors on sodium-lithium countertransport (SLC), we determined the activity of this transport system in 14 healthy volunteers, who are nonhabitual drinkers, before and 1 hour after intake of alcohol (0.8g/kg) with "Coke" as the vehicle. Alcohol significantly increased the "leak pathway" component of lithium efflux from a baseline value of 0.21 +/- 0.02 to 0.24 +/- 0.02 mmol/Lcell.h(p < 0.003); and reduced the Vmax of the transporter (0.38 +/- 0.05 to 0.31 +/- 0.04mmol/Lcell.h;p < 0.0005) without significantly changing its affinity for external sodium. The reduction in Vmax was dependent on the initial activity of the transporter (r2 = 0.5). A plot of reduction in Vmax against the product of initial Vmax value and blood alcohol level in each subject revealed a stronger relationship (r2 = 0.86), suggesting that the observed change in Vmax was also dependent on blood alcohol level. Coke alone did not change any of the parameters. We conclude that alcohol acutely inhibits SLC as well as alters erythrocyte membrane in a manner that increases passive lithium efflux.

Adult↗
PubMedDate not supplied

Do epidurals cause back pain?

Postpartum back pain may occur in up to 44% of women after childbirth. The increasing use of epidural analgesia during labour over the past 35 years has led many women and some doctors to attribute postpartum back pain to this. Such suggestions, if unfounded, may undermine parturients' confidence in epidural analgesia. However, the outcome of recent, randomized studies clearly shows that epidural analgesia does not cause back pain.

Analgesia, Epidural↗