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D Buiuc

Publications and source records attributed to D Buiuc.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[New derivatives of pyrazolo- and tetrazolobenzoquinolines with antimicrobial action].

The conditions for obtaining and the properties of some new diazabicyclic compounds is the new step in our investigation on the benzocynoline derivatives. The structure of the new compounds was confirmed by elementary (C, H, N) and spectral analyses. The antimicrobial tests evidenced that part of the newly synthetized compounds have a good antifungal action.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Contribution of the microbiology laboratory to renal and urinary studies. Bacteriological examination of urine].

A. General considerations: 1. Microbiological condition of the normal urine and urinary tract; 2. Infections of the urinary tract. B. Possibilities of the laboratory of microbiology in renourinary investigations: 1. Detection and significance of pathogenic microorganisms in the urine; 2. Quantitative uroculture: a. The significance of urocultures in asymptomatic bacteriuria; b. The significance of bacteriuria in clinical diseases of the urinary tract. 3. Other diagnostic possibilities in urinary tract infections. 4. Possible microbiologic localization in urinary infections. a. Washing the urinary bladder; b. Urethral catheterism; c. Evidence of bacteria-antibody complexes in the urine; d. Bacteriologic localization pattern in bacterial urethritis and prostatitis. 5. Testing against antibiotics. C. Bacteriologic examination of the urine: 1. Collecting the urine for bacteriologic examination: a. Collecting from the middle jet: I) from women II) from men III) from imobilized patients IV) from children b. Collection by suprapubic puncture 2. Screening methods and tests 3. Methodology and diagnostic tests in urinary tract infections. a. Cultures; b. Follow up of the results. c. Reporting the results.

Bacterial Infections↗
PubMedDate not supplied

[Typhoid bacilli resistant to chloramphenicol and multiresistant to antibiotics isolated at the beginning of 1971].

The sensitivity of chloramphenicol (C) of 286 S. typhi strains, isolated during the last 15 years in Moldavia, was tested. The minimum inhibitory concentration (MIC) of C with regard to most of the strains ranged between 1.5 and 3 mcg/ml. The following stains were identified: strain W isolated from the feces of a carrier in 1971, with a ACKSSuT-Cl2Hg resistance spectrum transferable to E. coli K12(MIC of C less than or equal to 200 mcg/ml), 2 strains (phage type A and C1, isolated from patients, one from the feces in 1972 and the other haemoculture in 1973) with a non-transferable CSu resistance spectrum (MIC of C less than or equal to 6 and less than or equal 12 mcg/ml respectively), and 18 strains (13 phage type D9, 3 phage type Ci and 2 phage type A), isolated from 3 epidemic foci, which proved to contain variants selectable in vitro by C (MIC up to 50 mcg/ml). The resistance spectrum of the variants was not CSU transferable. Conclusions are drawn concerning the necessity of a restricted utilization of chloramphenicol.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Pharmacological studies of sulbactam and its association with semisynthetic beta-lactam antibiotics].

The acute toxicity, local tolerance and pharmacokinetic properties of sulbactame manufactured by the Iaşi Antibiotic Investigation Centre, alone or in association with ampicillin or amoxicillin were tested. Some tests were made comparatively with the product Unasyn--Pfizer. The obtained data show that this beta-lactamase inhibitor has a low toxicity--DL50 i.p. in mice over 4,000 mg/kg, both alone or associated with the two semisynthetic beta-lactamic antibiotics. The local tolerance is good and the serum levels of the above mentioned associations are above towards the tested bacteria and are similar or very close to those of Unasyn. It is believed that the therapeutical use of the association sulbactame + ampicillin or sulbactame + amoxicillin is very useful in the beta-lactamase producing germs infection.

Amoxicillin↗
PubMedDate not supplied

[Further comment on the importance of microscopy in clinical microbiology. The argument for the diagnosis of the skin manifestations of histoplasmosis and coccidioidomycosis].

This paper presents two interesting cases: a patient with cutaneous coccidioidomycosis, the first case in Romania, and a female patient with latent histoplasmosis with cutaneous manifestations, periodically reactivated during her pregnancies. The etiological diagnosis problems of these affections in relation with the degrees of competence of the clinical laboratories is discussed. The role of direct microscopic examination in the early and more rapid diagnosis of deep mycoses is underlined.

Adult↗
PubMedDate not supplied

[A seroepidemiologic and virological study of the presence of arboviruses in Moldavia in 1961-1982].

In Romania, St. Drăgănescu et al., Miszkolczy et al., based on clinical and epidemiological observations, affirmed the possible presence of "tick-borne encephalitis (TBE)". However, critical retrospective evaluation of certain others' papers published through 1958-1971 reveal some uncommon features. By way of example: a very high incidence of CF- and HI-antibodies in acute and chronic CNS illnesses as well as in general population; replication in nucleus and maturation in mitochondria of a strain of "TBE virus" isolated from a patient CSF; isolation of "group B arbovirus" from Ixodes persulcatus on Romanian territory. As known, this tick was not identified in Romania, "no tick-borne Flavivirus isolated outside the U.S.S.R. proved to be a strain of RSSE virus" and "no arbovirus (Alpha- and Flavivirus or Bunyavirus) was ever detected in nucleus". Based on the HI reaction with West Nile (WN) virus, strain Egypt 101, human, domestic and wild vertebrates sera, treated with acetone for removal of nonspecific inhibitors, were tested as part of a control study, in Moldavia in 1961. WN virus was selected for its capacity to crossreact in the HI test with many members of the family Flaviviridae, genus Flavivirus (formerly Group B arboviruses), including the agents of Central European encephalitis. In order to avoid the interference of nonspecific inhibitors, a new single radial haemolysis test for the assay of antibodies to haemagglutinating arboviruses was calibrated in 1979. The seroepidemiological study performed on all 19.853 sera (10.698 human, 6.452 domestic mammals, 2.477 wild small rodents and 226 migrating aquatic birds) pointed out a very low circulation of Flaviviruses in the investigated area. The attempts to isolate such viruses from Ixodes ricinus on suckling mice yielded a single strain of Kemerovo (genus Orbivirus) virus. The need of extending the study to other viruses transmitted by arthropods and rodents, and mainly on the haemorrhagic fever with renal syndrome, an illness already clinically identified in Moldavia, is emphasized. Final consideration of viability (specificity, sensitivity, accuracy and precision) of the tests used and the need for continuous quality control is also presented.

Antibodies, Viral↗