Biomedical subjects
Publications and source records attributed to D Burduk.
Benign cartilaginous tumours of the larynx and trachea are rare. The most common is chondroma, and only 6 cases of osteochondroma of the larynx have been reported in the world literature. We present a case of 74 year's old woman with osteochondroma of the right arytenoid cartilage. This is followed by a review of the literature, diagnostic evaluation and surgical management.
The authors conducted examination of blood flow velocity in medial cerebral artery using Trans Cranial Doppler method and calculated pulsatility index (PI) in 35 patients after neck dissection operation. Similarly 35 patients after neck dissection had duplex Doppler examination of common and internal carotid arteries performed. Pulsatility and resistance indexes and blood flow capacity were estimated. We compared the results with the control group consisted of 15 patients operated on because of chronic otitis. We confirmed a neck dissection operation influence into cranial and cervical blood flow disturbances as well as relationship between postoperative soft tissue oedema and hemodynamical changes. We didn't found connections between cervical and cerebral blood flow and postoperative complications.
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Protein p53 was localized ultrastructurally with 5 nm gold-streptavidin particles in cells of laryngeal carcinoma embedded in Epon 815. Postembedding technique to study p53 protein was used. Protein p53 was found predominantly in nucleus of the cells but the label was also observed in cytoplasm of the cells. Five of 15 samples from patients with laryngeal carcinoma showed positive labeling for p53, (33.3% of all examined samples). Controls of tumor cells incubation with normal mouse serum showed no labeling with gold streptavidin particles.
To evaluate the influence of radical or functional neck dissection on cerebral hemodynamics, pre- and postoperatively TCD sonographic examinations were performed in a group of patients following unilateral radical or bilateral radical/functional neck dissection. Cerebral blood flow velocities (cm/s) and pulsatility index (PI) were studied preoperatively and postoperatively 4, 24 and 48 hours after the operation, using a 2 MHz-pulsed transcranial ultrasonographical system (TCD) with a transtemporal approach to the middle cerebral artery. To exclude the influence of general anaesthesia on cerebral circulation TDC was also performed in a group of patients, following operations under general anaesthesia but not radical nor functional neck dissection. The results of both groups were compared with the data obtained in a control group of healthy persons the same age. The reductions in blood flow velocities and concomitant increases in PI observed during the first postoperative insonation in patients after radical/functional neck dissection reflect a heightened resistance to flow in the arterial cerebral vasculature.
Some data in the literature indicate on the influence of different kind of surgery on the fibrinolytic process. Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1)--play important role in regulation of fibrinolysis. The aim of our work was to evaluate the influence of laryngectomy on fibrinolytic potential in the blood of operated patients with larynx carcinoma. Study group consisted of 20 men aged 42-75 years old with larynx carcinoma subjected to total laryngectomy. In the blood of patients we measured the concentration of t-PA:Ag, fibrinogen and FDP levels, PAI-1 activity, and ELT. The increase of t-PA and FDP concentrations, decrease of PAI-1 activity and fibrinogen level with simultaneous ELT shortening indicate on the fibrinolysis activation during the laryngectomy.
The authors performed epidemiological analysis of malignant neoplasms of the nose, paranasal sinuses, throat, tongue, larynx and salivary glands in Bydgoszcz area. All the patients were treated in the Otolaryngological Clinic of Medical Academy in Bydgoszcz. Patient's sex, age, profession, living and environmental conditions as well as histopathological diagnosis were taken into analysis. The data were referred to various regions of Bydgoszcz province, which were elucidated on the basis of microclimate conditions, industry, soil conditions, density of the forest area, and cultivated agriculture plants. Correlations between occurrence of oral cavity and the upper respiratory tract malignant neoplasms and living conditions as well as kind of profession in different parts of Bydgoszcz province were estimated.
Plasminogen activators and inhibitors regulate a variety of physiological and pathological processes involved in tissue morphogenesis, cell differentiation, migration, cancer cell invasion and metastasis. Several reports have shown the decrease of fibrinolytic activity in the blood of cancer patients. In this study we measured the concentrations of tissue plasminogen activator (t-PA), urokinase plasminogen activator (u-PA), activity of plasminogen activator inhibitor type 1 (PAI-1) and euglobulin lysis time (ELT) in the blood of 20 men aged 42-75 years old with planoepitheliale larynx carcinoma, and 10 healthy persons in similar age. In this study the mean values of t-PA, u-PA concentrations, PAI-1 activity and ELT in the blood of patients with larynx carcinoma were similar to the examination results of healthy persons, but 40% of our cancer patients have increased activity of PAI-1.
A very rare of the osteosarcoma osteolythicum teleangiectaticum of the paranasal sinuses, treated surgically, is reported. The infiltration and destruction of the sphenoid bone caused a haemorrhage from the cavernous sinus. The difficulties in the preoperative evaluation of the extent of the osteosarcoma in the craniofacial bone structures are discussed.
The authors present the surgical technique of stellate ganglion excision as a therapeutic method in patients with the long QT syndrome. The operations were performed through an anterior supraclavicular approach. Discussing the anatomic considerations, the possibilities of complications and side effects, both temporary and permanent, including Horner's syndrome are reviewed. On the base of the review of present literature and the postoperative results in patients treated in the Otolaryngological Department of the Medical Academy in Bydgoszcz, the authors confirm that the results of stellate ganglion excision in patients with the long QT syndrome are encouraging, but the possibilities of complications, including sudden death after stellectomy, must be taken into consideration.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.