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Biomedical subjects

D C Bergen

Publications and source records attributed to D C Bergen.

6 recordsLinked to original sources
PubMed1995

Weight loss in patients taking felbamate.

Felbamate is a new antiepileptic drug (AED) with a good safety profile. Anorexia has been reported in patients taking felbamate, but the incidence and severity of this side effect have not been adequately investigated. We studied 65 patients with intractable seizures who received adjunctive felbamate therapy as part of clinical research trials or in a compassionate-use program. Mean treatment time on felbamate was 23 weeks (+/- SD 16; range, 6-116 weeks). Forty-nine patients (75%) lost weight during the trials. For subjects older than 15 years, there was a mean weight loss of 3.17 kg or 4.11% of body weight (T = 191.5, z = 4.18, p < 0.001). For subjects 15 years or younger there was a mean weight loss 0.20 kg or a loss of 1.77% of body weight (T = 52.5, NS). Twenty-two patients (34%) lost > 4 kg, and seven patients (11%) lost > 8 kg. Adjunctive treatment of adults with severe epilepsy with felbamate may be associated with clinically significant weight loss.

Adolescent↗
PubMed1975

A device to measure cutaneous temperature sensitivity in humans and subhuman species.

A device is described to maintain restricted areas of skin at any temperature between 5 and 45 degrees C. Changes in temperature of controlled intensity up to 10 degrees C at rates from 0.03 degrees C to 2 degrees C/s can be delivered in either the warm or cool directions. The stimulator, which is in contact with the skin, is sufficiently simple so that a number of them can be constructed, each with a different contact area up to 18.2 cm2. The current control apparatus that operates a Peltier device in the stimulator is a feedback control system that maintains a precisely controlled temperature at the stimulator-skin interface. Safety features make it suitable and safe for use in human psychophysical studies and subhuman behavioral measurements of temperature sensitivity. Electrostatic shielding makes it compatible with the electronic instruments used in electrophysiological studies of the temperature sense.

Animals↗
PubMedDate not supplied

Bilateral Todd's paralysis after focal seizures.

Transient postictal hemiparesis or monoparesis is not uncommon after partial (focal) seizures. We report 2 patients who complained of severe bilateral limb weakness after generalized tonic-clonic seizures (GTCS) beginning focally. Bilateral Todd's paralysis was verified and documented in both patients. EEG and clinical evidence indicate the supplementary motor cortex as the most likely source of the seizures in both cases.

Adolescent↗