Autosomal dominant mucoid colon carcinoma: a study of a case and a kindred.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to D C Budd.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
An autosomal-dominant mucoid colonic carcinoma syndrome is described. Seventeen members of one family over three generations have experienced cancers, including 14 with adenocarcinoma of the colon. The defective autosomal locus is pleiotropic, producing adenocarcinoma of the endometrium, atypical endometrial hyperplasia, uterine leiomyosarcoma, and bladder transitional and renal cell carcinoma in addition to the mucoid variant of colon carcinoma.
Explore the source record for details and available documents.
The records of 146 consecutive patients with mastectomy operations over a three year period were reviewed. Of these, ninety-three (63.6 per cent) had one or more complications secondary to surgery. There were 175 complications, of which complications, of which 107 (73.2 per cent) were wound-related. Seroma formation occurred most frequently but was of minor consequence. The incidence of flap necrosis was 19.1 per cent, with cellulitis or suppurative infection appearing in thirteen patients. Immediate postoperative edema of the arm was fairly rare (2.7 per cent) and appeared related to delayed wound healing. Postoperative complications after total, modified radical, and radical mastectomy present problems unique from those seen after other major surgery, in that local complications predominate. The very nature of the procedure, with the creation of large thin skin flaps, extensive axillary dissection, and an open wound for a prolonged period of time, predisposes to wound morbidity.
Explore the source record for details and available documents.
A family pedigree containing sixteen individuals with acute appendicitis is presented. In all but one the position of the appendix was retrocecal. In two other members explored for abdominal pain wherein acute appendicitis was not the cause, the appendix was also found to be retrocecal. The anatomic retrocecal location of the appendix in this pedigree shows a degree of uniformity that implies a common predisposing factor inherited as a simple, dominant unit-character.
An unusual case of volvulus of the transverse colon associated with scleroderma is presented. The morphologic changes in the large bowel due to progressive systemic sclerosis, resulting in pseudo-obstruction, are considered in the etiology and pathogenesis of colonic torsion.
An instance of thyroglossal duct cyst in a 68-year-old man was reported. The clinical diagnosis of a thyroglossal duct cyst is suggested by the presence of a cystic mass situated anteriorly in the midline of the neck regardless of the patient's age. A review of the literature revealed that the incidence markedly decreases with age, with the great preponderance of cases occurring in infancy and childhood. Fourteen cases of thyroglossal duct cyst have been reported in the over-60 population.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
In this 13-year study, 51 patients were admitted with the primary diagnosis of "smoke poisoning" "carbon monoxide (CO) poisoning" or "respiratory burns." Forty patients (78%) had diagnosis of smoke poisoning with minor or no skin burns. The study indicated that clinical diagnosis of CO poisoning cannot be made reliably without carboxyhemoglobin (COHg) determination and that smoke poisoning patients often had CO poisoning. Seventeen of 19 smoke poisoning patients (89%) had CO poisoning above COHb levels of 15% saturation. Carbon monoxide was successfully removed from the blood by improving alveolar ventilation and oxygen concentration. However, there were 2 smoke poisoning deaths as the result of gaseous chemical injury. There was a correlation coefficient of 0.87 between initial COHg levels and patients' hospital days primarily determined by patients' pulmonary complications. Since CO is non-irritating, COHb levels may be used as an additional indicator of suspected pulmonary injury by noxious combustion gases.
Several surgeons have reported finding silk suture material as a nidus for common duct stones after cholecystectomy. They have therefore advocated the use of chromic sutures to ligate the cystic duct in order to avoid this complication. A case report is presented in which chromic suture material was found to be the source of common duct stone formation after cholecystectomy. A review of the literature indicated the relative infrequency of foreign suture material causing this problem. The suture used in the routine ligation of the cystic duct should be left to the technical preference of the surgeon.