Recurrence rate after highly selective vagotomy.
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Biomedical subjects
Publications and source records attributed to D C Busman.
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Serum gastrin levels were measured preoperatively and at several intervals postoperatively in 262 patients who underwent highly selective vagotomy for duodenal ulcer. An increase of serum gastrin levels was demonstrated postoperatively in all patients, irrespective of sex, length of history, acid secretion data or recurrence. At several years postoperatively, a highly significant secondary rise in serum gastrin levels was observed, which corresponded well to recent physiologic and morphologic data. The most suitable explanation appeared to be that the proximal gastric vagotomy (vagotomy of the fundus and corpus) abolished the vagally mediated inhibition of the G-cells in the antrum (disinhibition of the oxyntopyloric reflex). The serum gastrin values were always higher and the secondary postoperative increase was earlier for patients who had taken cimetidine preoperatively. Contrary to traditional expectations, no correlation at all was found between serum gastrin levels and acid secretion data. Recurrence could not be predicted on the basis of serum gastrin levels.
Clinical and laboratory results are presented of 229 patients treated by highly selective vagotomy for duodenal ulcer in a non-university teaching hospital. Sixty-two per cent of the operations were performed by residents as part of their training. After 1-8 years follow-up (97 per cent complete) there were 22 recurrences (9.6 per cent). The residents had fewer recurrences than the consultants, but their patients follow-up was shorter. The usual Visick grading is presented (1, 2: 83.5 per cent; 3, 4: 16.5 per cent) as well as an additional way of grading described by Visick in 1948 which suggests that 4 per cent appear to be permanent failures. Mortality rate was 0.4 per cent, complications rate was low and side effects were in general of minor importance. Laboratory results are presented showing that the basal acid output (BAO) was reduced permanently by 65 per cent, and the PAO by 50 per cent. In patients with recurrences BAO was not reduced and the PAO was less reduced than in the non-recurrence group. Metabolic parameters did not deteriorate. Basal serum gastrin rose after operation while serum vitamin B12 remained constant with a minimal tendency to decrease.
Opinion is fairly unanimous on the need for surgical treatment of disclocated olecranon fractures. However, opinions differ regarding the mechanical backgrounds and practical application of the presently widely used tension wiring. The article attempts to clarify the picture of the forces involved in the humero-ulnar joint. Basing on the points of attack of these forces and on the influence of the ligamentum collaterale ulnare, the fractures are subdivided into three groups with individual demands on the respective fixation method and the permissible post-operative exercise therapy. Post-operative plaster immobilisation is not indicated in these cases.
Retrospective examination of 27 patients with olecranon fractures who had undergone surgical treatment showed that--in agreement with theoretical considerations--osteosynthesis via tension wiring, although suitable for proximal fractures, is unsuitable for fractures of a more distal nature. A different method must be employed for distal fractures. Additional plaster immobilisation does not exercise any influence on consolidation, nor does it affect functional rehabilitation.
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