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Biomedical subjects

D C Gerke

Publications and source records attributed to D C Gerke.

At least 37 records · Page 2Linked to original sources
PubMed1986

A high-copper amalgam evaluated after three years in city and country practices.

The objective of the study was to compare the condition of Sybraloy restorations placed by the same operator in two different practice locations. Evaluations of the restorations were based on assessments for marginal fracture and staining, and for surface discoloration and roughness. Sybraloy restorations placed in a city practice were more satisfactory than those placed in a country practice. Surface discoloration proved to be unsatisfactory, especially in the country practice, but could be removed with light polishing.

Corrosion↗
PubMed1982

The comparative effects of prilocaine, lignocaine and cocaine on the response of the rabbit ear artery to adrenaline and noradrenaline.

The effects of prilocaine, lignocaine or cocaine together with either adrenaline or noradrenaline was tested by applying combinations of these preparations to an isolated rabbit ear artery and measuring changes in intra-arterial pressure. Potentiation of the response was greatest with combinations of local anaesthetic and adrenaline; with noradrenaline the response was significantly potentiated only when the lowest concentrations of cocaine were used. It is suggested that some of this effect could be attributed to the differential inhibition by the local anaesthetic agents of the neuronal uptake of the catecholamines. This inhibition was prominent with all combination which contained adrenaline, but only occurred with noradrenaline when that vasoconstrictor agent was combined with cocaine.

Animals↗
PubMed1980

Mouthguards for edentulous patients.

There are occasions when fully edentulous patients require mouthguards. The following paper describes both the constructions of a full upper and a lower denture-mouthguard and a case report involving such a prosthesis.

Adult↗
PubMed1978

The effects of agents modifying sympathetic nerve function on the response of the isolated rat tail artery to etilefrine and tyramine.

The effects of etilefrine on the ventral caudal artery of the rat have been examined in the presence of agents modifying sympathetic nerve function. Catecholamine levels were also measured in adjacent segments of artery to those studied pharmacologically and an attempt made to relate vascular response to etilefrine (and tyramine) with catecholamine content. Both guanethidine and reserpine produced significant attenuation of the vascular effects of etilefrine and tyramine. Pre-treatment with a monoamine oxidase inhibitor caused an increase in tissue catecholamine levels but, paradoxically, depressed the vascular response to etilefrine. The significance of some of the findings in terms of an indirect component to etilefrine's action are discussed.

Animals↗
PubMed1978

The effect of irradiation and heat on the content of adrenaline in commercially manufactured local anaesthetic solutions--a pilot study.

Carpules of commercially available local anaesthetic solutions containing adrenaline have been exposed to varying conditions of heat, ultra-violet and infra-red light over a period of two months. The adrenaline content in the solutions was assessed by fluorometric assay both at the commencement of study and at regular intervals over the period of exposure. Infra-red light appeared to have little or no effect on the concentration of adrenaline, while ultra-violet light, either alone or in combination with infra-red light, caused the adrenaline levels to diminish rapidly. The results suggest that the ultra-violet component of light is probably responsible for the breakdown of catecholamines in local anaesthetic solutions when these solution are stored in areas exposed to sunlight.

Epinephrine↗
PubMed1978

The use of mixtures of octapressin and adrenaline in local anaesthetic solutions to obtain more effective vasoconstriction.

The synergistic effects of felypressin with adrenaline have been studied using the isolated central artery of the rabbit ear as a vascular model. Sub-constrictor doses of felypressin were shown to increase adrenaline's vasoconstrictor effect on this vessel. It is therefore suggested that a mixture of felypressin and adrenaline be used in local anaesthetic solutions in order to provide more effective vasoconstriction.

Anesthetics, Local↗
PubMed1978

The indirect sympathomimetic activity of etilefrine--a comparison with tyramine and ephedrine using [3H] noradrenaline.

The indirect sympathomimetic activity of etilefrine has been examined using the ventral caudal artery of the rat. This vessel has a rich sympathetic innervation and lends itself to studies on [3H]noradrenaline efflux from these sites. Etilefrine possessed significant indirect activity on the artery and this action, although less than that of tyramine, was equivalent to that caused by ephedrine. Pretreatment of the vessels with a mixture of iproniazid, doca, cocaine and UO521 (3',4'-dihydroxy-2-methyl propiophenone) significantly enhanced[3H]-noradrenaline efflux from the artery.

Animals↗
PubMed1977

The effects of commercial local anaesthetic solutions on the isolated rabbit ear artery.

The response of an isolated artery preparation to commercial local anaesthetic solutions containing either prilocaine or lignocaine in the presence of adrenaline or noradrenaline has been examined. In low doses, both local anaesthetics were found to augment the constrictor response to adrenaline, wheras at higher doses the effect of adrenaline was significantly depressed by them. In contrast, noradrenaline's vasoconstrictor response was not potentiated by low doses of lignocaine, although higher dose levels caused a significant reduction in its vasoconstrictor effect.

Anesthetics, Local↗
PubMed1977

The effect of storage on the activity of adrenaline in local anaesthetic solutions: an evaluation using bioassay and fluorometric techniques.

The adrenaline content of local anaesthetic solutions has been assessed using a bioassay system and a fluorometric assay method. It was found that exposure of the solutions to daylight for a period of six months greatly reduced their adrenaline content, whereas storage of the same solutions under refrigeration or in the dark reduced the decrease in catecholamine content. Solutions containing adrenaline which were shown in the clinical situation to give inadequate anaesthesia were also tested. The analysis revealed a decline of catecholamine content in each solution.

Animals↗