Biomedical subjects

D C Hobbs

Publications and source records attributed to D C Hobbs.

21 records · Page 2Linked to original sources

PubMedDate not supplied

Piroxicam pharmacokinetics in man: aspirin and antacid interaction studies.

Pharmacokinetic studies with piroxicam, a nonsteroidal antiinflammatory agent, have been carried out following the administration of single and multiple oral doses. A plasma half-life of approximately 45 hours is observed, permitting the use of single daily doses in therapy. Enterohepatic recirculation of drug is suggested by the presence of multiple peaks in plasma concentration curves. Piroxicam is highly bound to serum proteins. The absorption and disposition of piroxicam are unaffected by the concomitant administration of aspirin and antiacids. Salicylate plasma levels are similarly unaffected by piroxicam administration.

Antacids↗

PubMedDate not supplied

Metabolism of sudoxicam by the rat, dog, and monkey.

Sudoxicam, N-(2-thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1, 1-dioxide, was prepared in radiolabeled form and administered to rats, dogs, and monkeys. Urine contained approximately 60, 25, and 49% of the label given to rats, dogs, and monkeys, respectively; the remainder was cleared via feces. In addition to some unchanged drug, urine from all species examined contained two major metabolites. These were identified from their mass spectra as the thiohydantoic acid and thiourea resulting from scission of the thiazole ring of sudoxicam.

Administration, Oral↗

PubMedDate not supplied

Metabolism of piroxicam by laboratory animals.

Piroxicam, a potent new nonsteroidal antiinflammatory agent, was radiolabeled in a biologically stable position by tritium exchange and administered at doses of 20 mg/kg to the rat, dog, and rhesus monkey. Metabolites were isolated from excreta by chromatographic methods and identified by their mass spectra and by comparison with authentic samples. Piroxicam is metabolized by cyclodehydration, by hydroxylation on the pyridyl moiety, and by a sequence of reactions involving amide hydrolysis, decarboxylation, ring contraction, and N-demethylation. In the rat, piroxicam is also metabolized by hydroxylation in two positions on the benzothiazine nucleus.

Animals↗