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Biomedical subjects

D C McLean

Publications and source records attributed to D C McLean.

9 recordsLinked to original sources
PubMed1994

Molecular cloning of an Onchocerca volvulus extracellular Cu-Zn superoxide dismutase.

Onchocerca volvulus, a human parasitic nematode, is the third leading cause of preventable blindness worldwide. This study describes the molecular cloning of a novel superoxide dismutase (SOD) from the parasite. This putative O. volvulus extracellular SOD (OvEcSOD) is 628 nucleotides (nt) long, including a 22-nt 5' spliced leader (SL1) and a portion encoding an N-terminal hydrophobic 42-amino-acid signal peptide. The remainder of the cDNA shares 71% identity with an O. volvulus cytosolic SOD sequence and is 3 nt longer. All residues involved in metal ion binding, active site formation, folding, and dimer formation in SODs are conserved. Data indicate the OvEcSOD and O. volvulus cytosolic SOD are separate gene products and that the OvEcSOD appears to possess the characteristics of a membrane-bound or secreted enzyme which may be involved in the parasite defense against phagocyte-generated reactive oxygen species.

Amino Acid Sequence↗
PubMed1987

Insect sting allergy.

Hymenoptera venom is a well recognized cause of allergic reactions. These allergic reactions are common and may at times be life threatening. Precautions such as avoidance and the possession (and use) of epinephrine can decrease the incidence and severity of such reactions. Venom immunotherapy is the treatment of choice in those patients who have had systemic allergic reactions and are shown to be vespid allergic by skin testing.

Adolescent↗
PubMed1977

Capacity of young males and females for running in desert heat.

Tolerance for sustained activity in the desert at about 40 degrees C was assessed on high school students, mostly athletically oriented and scholastically superior. The 14 males compared with the 12 females had an aerobic capacity greater by about one-half and a percentage of body fat smaller by about one-half. Each sex attained about the same percentage of aerobic capacity in their maximal sustained effort. This involved an increase in metabolic rate of 3 to 5 fold in females and 6 to 8 fold in males. In maximal sustained effort responses of males and females were alike in respect to rectal and skin temperatures and heart rate. At a rate at which nearly all walked for one hour, 100 m/min, there were no significant differences in metabolic rate, sweat rate nor in composition of sweat. Running at 120 m/min required maximal effort by most females; their maximal sweat rates ranged from 7.4 to 14.2 ml/m2.min. Most males were able to run at 160 m/min for one-half hor to one hour; their maximal sweat rates ranged from 11.3 to 14.6 m/m2.min. Superior capacity of males over females for sustained exercise in desert heat is related to their higher aerobic capacity and not to a difference in capacity for thermoregulation.

Adolescent↗