Biomedical subjects
D C Morley
Publications and source records attributed to D C Morley.
AIDS: Third World beware?
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Protrusio acetabuli prosthetica.
Protrusio acetabuli prosthetica is a form of hip replacement failure in which intrapelvic component migration occurs. Three degrees of the entity are defined as determined by (1) prosthetic migration medial to the ilioischial line and (2) integrity of the medial acetabular wall. Entities predisposing to protrusio acetabuli prosthetica include overreaming, multiple pelvic perforations, osteopenic bone states, infection, trauma, heredity or acquired bone deficiency states, overactivity, and hypertrophic membrane formation. Treatment of the condition is contingent upon (1) reestablishment of the radiographically determined anatomic position of the acetabulum and (2) construction of a medial prosthetic or biologic buttress. Recent techniques of biologic medial-wall formation utilize either allograft or autograft bone in one of three configurations--bulk, chipped or pulverized. In cases of severe intrapelvic hip protrusion, resection arthroplasty may be the only alternative.
Factors influencing in vitro production of colony-stimulating factor by mononuclear leukocytes from humans.
The purpose of this study was to identify factors that influence the production of colony-stimulating factor by leukocytes of humans. The use of nonadherent light-density bone marrow cells is semisolid agar cultures to assay the concentrations of colony-stimulating factor in the supernatant of monocyte and mononuclear leukocyte cultures made it possible to distinguish between colony-stimulating factor, which stimulates colony-forming cells directly, and monocyte-dependent stimulating activity, which acts indirectly, by increasing the monocyte production of colony-stimulating factor. Colony-stimulating factor was not detectable in the cytosol of monocytes; that detected in culture must, therefore, have been newly synthesized. Synthesis was enhanced independently by heat-inactivated human serum and by semipurified serum fractions enriched with monocyte-dependent stimulating activity. The kinetics of the production of colony-stimulating factor in the presence and absence of monocyte-dependent stimulating activity indicated that the latter facilitated monocyte production of the former. Factors released from neutrophils were shown to reduce the production of colony-stimulating factor and thr proliferation of colony-forming cells and thus may provide a feedback control mechanism limiting the proliferation of neutrophils.
Limitation of film strip and bangle test for identification of malnourished children.
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Continuing education for the health team in developing countries.
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Effect of lithium on granulopoiesis in culture.
Lithium carbonate therapy is associated with polymorphonuclear leukocytosis. In vitro studies have shown that lithium ions stimulate formation of granulocytic colonies. In a study undertaken to determine how lithium acts, colony-forming cells uncontaminated by monocytes (which elaborate colony-stimulating factor [CSF] in vitro) were obtained by means of a two-step cell separation procedure. The effects of lithium on colony formation were then studied in (a) cultures stimulated by humoral CSF, (b) cultures in which monocytes were relied upon to synthesize CSF de novo and (c) unstimulated cultures. Lithium enhanced the action of CSF but did not stimulate colony formation in the absence of CSF. In monocyte-stimulated cultures, colony formation increased with lithium concentrations up to 1 mmol/L but this increase paralleled that in CSF-stimulated cultures and therefore was not due to increased CSF production by monocytes. At higher concentrations of lithium, colony formation decreased in the monocyte-stimulated cultures but increased in the CSF-stimulated cultures. A lithium concentration of 4 mmol/L gave the greatest enhancing effect on colony formation in CSF-stimulated cultures and a concentration greater than 1 mmol/L inhibited de novo synthesis of CSF by monocytes.
An accurate weighing scale for all ages.
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Is the prestigious teaching hospital in the Third World a disaster?
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Measles in the developing world.
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Teaching aids at low cost: an organization for the production and distribution of audio-visual aids overseas.
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Measles and measles vaccine in pre-industrial countries.
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Administration of measles vaccine by dermojet.
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[A simple statistical method for achieving reliability in anthropometric measurements].
Most anthropometric studies fail to comment on the reliability of the measures. The authors assume that the complexity of the classical analysis of variance approach is one of the reasons for this. They therefore describe a simpler, yet scientifically sound method which assesses three sources of measurement error: intra and inter-observer as well as instrument errors. The measure of upper-arm-circumference of pregnant women, which has been proposed to be a predictor of birth-weight, is used as an example. Reliability was assessed by calculating agreement of a series of pairs of measurements. Inter and intra-observer-errors were found to be of the same size. Both types of human errors were statistically significantly greater than the error arising from the use of two different types of tapes (instrument error). It is hoped that other authors find this approach useful so that information on reliability in anthropometric studies becomes the rule rather the exception.