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Biomedical subjects

D C Stolinsky

Publications and source records attributed to D C Stolinsky.

At least 37 records · Page 2Linked to original sources
PubMed1981

Prolonged survival after cerebral metastasis of testicular carcinoma.

A 30-year-old man underwent orchiectomy in 1962 for a testicular carcinoma composed of choriocarcinomatous and teratocarcinomatous elements. Bilateral pulmonary metastases regressed completely on combination chemotherapy. However, a cerebral metastasis developed in 1963 and caused severe neurologic signs. At craniotomy a large mass of choriocarcinomatous tissue was incompletely removed. Further chemotherapy resulted in a complete remission. The patient remains free of disease more than 16 years later. The treatment of cerebral metastasis is discussed, with emphasis on the possibility of long-term survival and the role of surgery.

Adult↗
PubMed1980

Rotational therapy with a colchicine analog in chronic granulocytic leukemia.

9 patients with chronic granulocytic leukemia were treated sequentially with busulfan, 6-mercaptopurine, and trimethylcolchicinic acid methyl ether d-tartrate (TMCA; NSC-36354). Smoothness of control of the disease was similar with busulfan and 6-mercaptopurine, but it was significantly poorer with TMCA. Toxic effects of therapy and median survival were similar to those observed with conventional therapy.

Adolescent↗
PubMed1980

Paraneoplastic syndromes.

Neoplasms can produce a variety of remote effects on the host; these are referred to as paraneoplastic syndromes. The syndromes may affect any of the systems of the body, may precede or follow the diagnosis of the underlying neoplasm, and may or may not parallel the course of the neoplasm in severity. The diagnosis of and therapy for these syndromes can be challenging to a physician, but successful therapy may bring about worthwhile relief for the patient. In addition, the syndromes and the substances that cause them are sometimes useful in diagnosing and in following the course of certain neoplasms. Perhaps of greater importance, study of these remote effects of neoplasia may shed light on the nature of the neoplastic process itself.

Adult↗
PubMed1978

Emergencies in oncology. Current management.

Malignant neoplasms may cause life-threatening complications requiring prompt diagnosis and emergency therapy. Whether or not the underlying neoplasm is potentially curable, the physician can often provide worthwhile prolongation of life and dramatic symptomatic relief. Among the serious complications of neoplasia are superior vena cava obstruction, airway obstruction, pericardial tamponade, spinal cord compression, brain metastasis, meningeal involvement by cancer, hyperuricemia, hypercalcemia and hyperkalemia.

Airway Obstruction↗
PubMed1976

Effect of trimethylcolchicinic acid methyl ether d-tartrate (TMCA) on Hodgkin's and non-Hodgkin's lymphoma.

Trimethylcolchicinic acid methyl ether d-tartrate (TMCA; NSC-36351) was administered daily by mouth to 71 patients with malignant lymphomas. Partical (greater than 50%) responses were observed in eleven of 37 patients with Hodgkin's disesse, two of 22 patients with lymphocytic lymphoma, and one of two patients with mixed cell lymphoma. One complete and three partial responses were noted in nine patients with histiocytic lymphoma. Responses lasted from one to 91+ months (median: four months) and occurred in patients whose disease was resistant to alkylating agents, vinblastine, vincristine, procarbazine, prednisone or BCNU. Toxic effects included leukopenia, thrombocytopenia, nausea, diarrhea, stomatitis, alopecia and dermatitis.

Antineoplastic Agents↗
PubMed1976

Results with CCNU in resistant Hodgkin's and non-Hodgkin's lymphoma.

72 patients with advanced malignant lymphoma resistant to standard chemotherapy were treated with 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) at 130 mg/m2 orally every six weeks. Objective responses were noted in 13 of 39 evaluable patients with Hodgkin's disease, three of 15 patients with lymphocytic lymphoma, and one of seven patients with histiocytic lymphoma. Responses lasted one to 22 months (median: four months) and occurred in patients whose disease was resistant to alkylating agents, vinblastine, vincristine, corticosteroids, procarbazine, and bleomycin. Leukopenia and thrombocytopenia were frequent toxic effects of therapy.

Administration, Oral↗
PubMed1971

Semantics of care.

Explore the source record for details and available documents.

Personal Health Services↗
PubMedDate not supplied

Twelve-year remission of polycythemia vera following Hodgkin's disease and chemotherapy.

Polycythemia vera is a condition characterized by the overproduction of red blood cells, and in many cases of leukocytes and platelets as well, in the absence of hypoxia or other known inciting factors. The association of polycythemia vera and acute leukemia is well known, but the author is unaware of prior reports of polycythemia vera and Hodgkin's disease concurrent in the same patient.

Cyclophosphamide↗