Biomedical subjects

D C Wu

Publications and source records attributed to D C Wu.

58 records · Page 4Linked to original sources

PubMed1980

Surgical management of ventricular septal defect in infancy.

Symptomatic ventricular septal defects in infants who responded poorly to intensive medical therapy require surgical intervention. This paper aims to compare the results of the two stage approach of initial pulmonary artery banding followed by debanding and ventricular septal defect closure with primary intracardiac repair in infancy. Thirty-six infants underwent pulmonary artery banding between 1968-1979 with two operative deaths (5.6%). Eighteen patients underwent pulmonary artery debanding and closure of ventricular septal defect between 1971-1979 with five operative deaths (25.6%). However during 1978-1979 ten patients underwent 2nd stage repair with no operative death. During the same period primary intracardiac repair in infancy was carried out in nine infants with three operative deaths (33.3%). There appears to be still a place for two stage treatment of symptomatic ventricular-septal defect in critically ill infants certain situation.

Cardiac Surgical Procedures↗

PubMed1980

Surgery for mitral restenosis.

Four hundred and twenty-five patients underwent mitral valvotomy between 1960 and 1979, the majority by the closed method. Thirty-two patients required another operation for mitral restenosis. There was high incidence of reoperation after the 6th and 7th years (23.3%) and after the 9th and 10th years (26.4%) postoperatively. Sixteen patients (47%) with restenosis underwent a second closed mitral valvotomy with a satisfactory result, 12 patients (35.4%) required valve replacement, and 6 patients (17.6%) had an open valvotomy. Another valvotomy for pure mitral restenosis can give satisfactory results, but where the valve is severely deformed or incompetent, valve replacement is preferred.

Adolescent↗

PubMedDate not supplied

Utility of brushing cytology in the diagnosis of Helicobacter pylori infection.

OBJECTIVE: We performed brushing cytology during routine gastroendoscopic examinations to evaluate the utility of gastric brushing cytology in the diagnosis of Helicobacter pylori infection. STUDY DESIGN: The brushing cytology materials were obtained from the antrum of the stomach in 107 patients. The urea breath test, biopsy urease test and histology with hematoxylineosin staining were also performed on each patient. We then compared the results of brushing cytology with those of the three other tests (13C urea breath test, biopsy urease test, histology). RESULTS: Fifty-nine of 103 patients (57%) were diagnosed as positive for H pylori organisms using brushing cytology. Using positive or negative results from any two of the other three tests as the gold standard, a true positive result was found in 57 cases, a true negative in 43 cases, a false positive in 2 cases and a false negative in 1 case. The sensitivity and specificity of brushing cytology were 98% and 96%, respectively. CONCLUSION: Gastric brushing cytology provides an accurate, inexpensive and easy technique in the rapid detection of H pylori infection. Brushing cytology also has the advantage of being applicable to diagnostic endoscopy without waiting days for results.

Biopsy↗

PubMedDate not supplied

Evaluation of an office-based urine test for detecting Helicobacter pylori: a Prospective Pilot Study.

BACKGROUND/AIMS: To ascertain the reliability of a newly developed office-based urine test, the RAPIRUN test, used for detection of H. pylori infection. METHODOLOGY: Urine specimens from 142 consecutive patients undergoing gastroendoscopy (77 men, 65 women; mean 52.0 years) were tested with RAPIRUN at the same time. The total reaction time for the urine test is 20 min. None of the patients had received any H. pylori eradicating treatment. The H. pylori status was evaluated based on 5 different tests: culture, histology, biopsy urease test, 13C-urea breath test, and the RAPIRUN test. A commercial office-based kit using an immunochromatographic technique was used to examine urine samples for H. pylori antibody. H. pylori status was defined as positive when the culture was positive or if 2 of the other 3 tests (histology, biopsy urease test, and 13C-urea breath test were positive. RESULTS: Of 93 patients with H. pylori infection, 88 were tested as positive by RAPIRUN (sensitivity 94.6%). Of 48 patients without infection, 43 were found to be negative by RAPIRUN (specificity 89.6%). One case with an invalid urine test was excluded. CONCLUSIONS: This urine test is a rapid, inexpensive, reliable and easy-to-use tool for the diagnosis of H. pylori infection in untreated patients. It can be used for mass screening of patients' H. pylori status, particularly in children, postgastrectomy patients, uncooperative patients, and patients undergoing bismuth or proton pump inhibitor treatment.

Adenocarcinoma↗