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Biomedical subjects

D C van der Zee

Publications and source records attributed to D C van der Zee.

At least 37 records · Page 2Linked to original sources

One-stage Duhamel-Martin procedure for Hirschsprung's disease: a 5-year follow-up study.

BACKGROUND/PURPOSE: With the introduction of the Endo-GIA stapling device the 1-stage Duhamel-Martin procedure became feasible for neonates and infants. Early results were promising. So far there were no meaningful data on the long-term functional results. This study shows the 5-year follow-up results after 1-stage Duhamel-Martin procedure for Hirschsprung's disease in neonates and infants. The results are compared with a historical group of patients from the same institution undergoing a 3-stage procedure. METHODS: Between September 1991 and December 1993 Hirschsprung's disease was diagnosed in 29 children. In 22 of them the disease was found within the first 2 months of life. In 19 children aganglionosis was restricted to the rectosigmoid colon. In 10 the innervation disturbance extended further, twice with involvement of the distal ileum. Initial treatment consisted of daily rectal irrigation. Postoperative follow-up on a regular out-clinic basis was 6 years (range, 5 to 7 years). Patients were scored for fecal continence, soiling, the use of laxatives, cannulae or rectal irrigation, enterocolitis, gain of body weight, and length. RESULTS: There were no intraoperative complications. The median postoperative stay was 7.7 days. Seven children encountered complications for which admission was necessary. Ultimately, 15 children have normal spontaneous defecation. Eight children display irregular soiling, without using laxatives. At 5-year follow-up 6 children are still on some sort of laxative or rectal irrigation. Mean growth and body weight is along the P50 and P50 to 90, respectively. These functional results are no different from those in the patients after 3-stage Duhamel-Martin procedure. CONCLUSIONS: There appears to be no difference in functional outcome after 1- or multiple-stage Duhamel-Martin procedure for Hirschsprung's disease after 5 to 7 years. The majority of children seem to fare well with restrictive need of laxatives. The advantage of a 1-stage procedure is the prevention of stoma-related complications, 1 or 2 additional operations, and extra scar formation.

Digestive System Surgical Procedures↗

Laparoscopy in infants and children: a prospective study on feasibility and the impact on routine surgery.

BACKGROUND/PURPOSE: The feasibility of laparoscopy in children and its impact on routine pediatric surgery are not well established. The purpose of this study was to determine the role of laparoscopy in a university department of pediatric surgery. METHODS: All children undergoing laparoscopy during the period of 1 year were included in a prospective trial. Data on patients, the operation, technical problems, intraoperative events, and the postoperative course were documented using standardized questionnaires. All patients underwent at least 1 follow-up assessment 2 weeks after the operation. All conventional abdominal operations performed during the same period were analyzed for comparison purposes. RESULTS: Of 244 abdominal operations performed during the study period, 147 (60.2%) were laparoscopies. One hundred twenty-three (83.7%) of these included a laparoscopic operation, and 24 (16.3%) were diagnostic procedures. Of 26 types of laparoscopic operations 3 were performed more than 15 times (fundoplication, appendectomy, pyloromyotomy), and 9 types were performed once. Problems with instruments and devices led to a mean time loss of 15.1 minutes in 15.6% of the procedures. The conversion rate was 10.1% mainly because of complicated appendicitis. Fifty-six children (38.1%) weighed less than 10 kg, and the conversion rate did not correlate with the body weight. There was 1 (0.07%) intraoperative event. A small bowel perforation was identified immediately and resolved with an uneventful course. Postoperative complications included an incisional hernia in 3 children and an incisional leakage of liquor in 1 child with a ventriculoperitoneal drain. There was a reprolaps after laparoscopic correction of an ileostomy in 1 child and fever in another. In 3 newborns the diagnosis was missed during laparoscopy and had to be established by laparotomy later with an uneventful course. Primary conventional operations were mainly restricted to bowel resection and anastomosis performed in 52 of 97 laparotomies. CONCLUSIONS: The authors showed that 60% of abdominal operations in children can be performed via laparoscopy. Most types of laparoscopic operations are not performed frequently, but the feasibility of the technique in routine use is excellent. However, the performance of instruments should be improved further, and laparoscopy for establishing the diagnosis in newborns remains difficult.

Abdomen↗

The value of 24-h pH study in evaluating the results of laparoscopic antireflux surgery in children.

BACKGROUND: The performance of laparoscopic antireflux surgery is steadily increasing among pediatric surgeons. Different techniques are being used. However, due to a lack of standardized follow-up methods, postoperative results are difficult to compare. In this study, we describe the results of postoperative 24-h pH study as an objective criterion for evaluating the results of laparoscopic Thal antireflux surgery. METHODS: In a prospective study, 53 patients underwent a laparoscopic Thal procedure. Preoperatively, all patients were subjected to 24-h pH monitoring, an upper GI series, and esophagogastroscopy. pH monitoring was performed 3 months postoperatively to evaluate the effect of the fundoplication. Esophagogastroscopy was repeated in case of preoperative esophagitis. RESULTS: In one patient, the laparoscopy was converted to an open procedure. Feeding was commenced on day 1 in 49 of the 53 children. Mean hospitalization time was 4.4 days. One patient was reoperated for a too-tight fundoplication, and two patients died of unrelated causes. Ultimately, 44 of 50 children (88%) were free of symptoms; however, 11 of 41 children (25%) still displayed pathological reflux on pH monitoring. CONCLUSIONS: The Thal fundoplication can be performed laparoscopically in children. Children have a quick recovery, and hospitalization is short (4.4 days). At follow-up, nearly 90% of the children are free of symptoms. However, 25% still have pathological reflux as measured with pH monitoring. Therefore, questionnaires alone are not a sufficient means of measuring outcome postoperative. pH monitoring is a valuable additional tool for the objective postoperative evaluation of the results of (laparoscopic) antireflux procedures.

Child↗

Management of adhesive bowel obstruction in children is changed by laparoscopy.

BACKGROUND: With new advances in diagnostic and therapeutic tools, the early management of adhesive bowel obstruction has become feasible. METHODS: In a retrospective study, 20 children with adhesive bowel obstruction were investigated to assess the possible advantages of the laparoscopic approach. RESULTS: Laparoscopy was performed in nine children. Six of them were managed laparoscopically. Recovery was uneventful. In two children, extensive adhesions warranted elective conversion. The single complication occurred in a child with obstruction of the colon due to perforation caused by a small instrument. Eleven children underwent primary laparotomy for adhesive obstruction. Five of them had a single band and might have benefited from a laparoscopic approach. CONCLUSIONS: Laparoscopic management of adhesive bowel obstruction in children is feasible and safe in experienced hands. Early management saves the child a great deal of discomfort and allows a quick recovery with early discharge.

Adolescent↗

[Good results of laparoscopic Thal fundoplication for treatment of gastroesophageal reflux in children].

OBJECTIVE: Evaluation of the results of laparoscopic fundoplication according to Thal as a treatment for gastro-oesophageal reflux in children. DESIGN: Prospective, descriptive. SETTING: Department of paediatric surgery, Wilhelmina Children's Hospital, Utrecht, the Netherlands. METHODS: Between November 1993 and May 1996, 53 children with reflux and an average age of 6 years underwent laparoscopic fundoplication according to Thal; in 23 of them a gastrostomy was created as well. The most important symptoms were vomiting and lack of growth. There were 18 children with primary reflux and 35 with secondary reflux, 28 of whom had psychomotor retardation. Preoperatively all patients were subjected to 24-hour oesophageal pH-monitoring, upper GI series and oesophagogastroscopy. Pathological reflux was defined as a pH < 4 during 5% or more of the total time measured (24 hours). pH-monitoring was repeated three months postoperatively to evaluate the effect of the fundoplication and esophagogastroscopy was repeated in case of preoperative oesophagitis. RESULTS: In one patient the laparoscopic approach was converted peroperatively because of bleeding that had stopped on exploration. Enteral feeding could be recommenced on day one in 49 of 53 children. The mean hospitalisation time was 4.4 days. One patient was reoperated for a too tight fundoplication and two patients died of unrelated causes. The mean follow-up period for the other 50 patients was 11 months (1-35). On follow-up, 42 of them (84%) were free of symptoms, while 31 of 41 children (76%) in whom pH-monitoring could be done 3 months postoperatively displayed no recurrence of pathological reflux. CONCLUSION: Thal fundoplication can be performed laparoscopically in children. Enteral feeding becomes possible again quickly and the period of hospitalisation is short.

Adolescent↗

Trocar fixation during endoscopic surgery in infants and children.

The slipping of trocars is a major problem, especially in pediatric laparoscopic surgery. Although the suturing of a trocar, along with its valve housing, to the fascia or skin is common, this technique only serves to prevent the trocar from being pulled out. We have found that the simple procedure of winding a +/- 1-cm broad tape several times around the base of the trocar, which has been sutured to the fascia or skin, will prevent the trocar, from being pushed in, even during lengthy operations. The tape that we use is derived from sterile disposable drapes and is therefore not only readily available but also an inexpensive solution to a chronic problem.

Abdominal Muscles↗

Is laparoscopic pyloromyotomy superior to open surgery?

BACKGROUND: We set out to determine whether laparoscopic pyloromyotomy (LPM) is superior to open pyloromyotomy (OPM) in babies with hypertrophic pyloric stenosis (HPS). METHODS: We performed a retrospective study of 36 LPM and 36 OPM. Both groups were comparable in terms of sex, age and weight on admission, and blood pH on admission and prior to surgery. In the LPM group, three trocars were used; in the OPM group, a small right upper quadrant transverse muscle-cutting laparotomy was carried out. RESULTS: LPM produces a better cosmetic result, seems to produce less postoperative discomfort, and results in the absence of conversion in a shorter hospital stay. However, the duration of the operation was significantly longer (32 versus 18 min). Moreover, LPM clearly entailed more complications (three mucosal perforations against two, and two reoperations against none in the open group). CONCLUSIONS: The actual series does not favor the laparoscopic approach over the open one, in view of the relatively high complication rate. Babies who are operated laparoscopically, however, seem to have less postoperative discomfort, a shorter hospital stay, and a better cosmetic result. As we are confident that the complication rate and duration of the operation will drop with further experience, we will continue to do LPM. LPM is not easy and should only be carried out when substantial experience has been gained in the field of pediatric laparoscopic surgery.

Female↗

Laparoscopic clipping of the median sacral artery in huge sacrococcygeal teratomas.

Huge sacrococcygeal teratomas in the newborn can cause significant morbidity and even death due to cardiac failure, hemorrhage, or both. Surgical removal is the treatment of choice, but can indicate these events. Ligation of the median sacral artery, which always supplies the tumor, prior to its removal has been advocated, but in the past this procedure required a formal laparotomy. Nowadays, it can be easily accomplished laparoscopically, as this case report demonstrates.

Blood Loss, Surgical↗

Laparoscopic treatment of intestinal malrotation in children.

BACKGROUND: Laparoscopic treatment of intestinal malrotation in children is difficult, and most of our pediatric surgeon colleagues active in the field of laparoscopic surgery tell us that more often than not they must convert to an open procedure. Initially, we experienced much difficulty too, but after modification we were able to master the technique, and now we feel confident. We here describe the actual technique we use. METHODS: Our experience encompasses nine children treated during the past 18 months. Five of the children presented in the newborn period and four later. During laparoscopic surgery, it is of paramount importance to concentrate not on the loops of bowel, but on the duodenum. By starting to identify the duodenum, mobilizing it, and carrying on the mobilization of the small bowel down until the whole small bowel has been seen, the pathologic anatomy is easily unraveled. Moreover, an existing volvulus is automatically reduced and the bowel automatically put in a nonrotation position in the abdomen. RESULTS: All patients have done well, and no complications have been noted. Operative time has been reduced to about 1 hour. CONCLUSIONS: Laparoscopic treatment of intestinal malrotation in children is not so difficult provided certain rules, as described, are followed.

Humans↗

Cetrimide overdose.

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Anticestodal Agents↗

Maternoembryonic transfusion and congenital malformations.

There is an increasing number of reports relating chorionic villus sampling (CVS) to transverse limb reduction defects or the oromandibular limb hypogenesis complex. In addition, a correlation has been established between the severity of the defect and the gestational age when CVS is performed. Several hypotheses have been proposed for the increased incidence of congenital malformations after CVS including vascular disruption. Recently, it has been suggested that maternoembryonic transfusion can occur after CVS and that this can lead to a local antibody-mediated reaction, followed by local pathogenetic cell degeneration, i.e., apoptotic cell death, due to vascular disruption. This increased apoptotic cell death will ultimately result in congenital malformations. This paper describes an experimental model that can explain the pathogenesis of congenital malformations after CVS. The model designed uses a whole rat embryo culture technique and intracardiac injection of antisera, mimicking transplacental transfusion after CVS. Injection of antibodies directed against blood group antigens is capable of inducing increased apoptotic cell death. Immunological staining gives evidence of involvement of antibody-mediated reactions in the occurrence of apoptotic cell death. The dorsal aortae in 10-day-old rat embryos of 10-somite stages of development consist of a continuous endothelial cell layer. The effect of intracardiac injection of antisera on the dorsal aortae is only transient. Smaller vessels such as the pharyngeal arch arteries or arteries of the limbs still have fenestrated endothelium and are therefore more vulnerable to the pathogenetic effect of the reaction after transplacental transfusion causing vascular disruption. Development of the vascular pattern and differentiation of the vascular wall reduce the risk of severe malformations later on in pregnancy, although the risk of malformations remains throughout pregnancy. Thus, intracardiac injection of antisera simulating maternoembryonic transfusion such as after CVS can lead to an antibody-mediated reaction with vascular disruption early in pregnancy inducing apoptotic cell death. Increased cell death may ultimately result in congenital malformations, such as transverse limb defects or the oromandibular limb hypogenesis complex.

Animals↗

Laparoscopic Thal fundoplication in mentally retarded children.

BACKGROUND: An increasing number of reports indicate that Thal fundoplication is the procedure of choice in mentally retarded children. With the advent of laparoscopy, Nissen's fundoplication seems to have been repopularized. However, the choice of the operative technique should be based on the merits of the procedure itself rather than the laparoscopic feasibility. The aim of this study is to determine if laparoscopic Thal fundoplication is beneficial for mentally retarded children. METHODS: Between November 1993 and 1994 laparoscopic Thal fundoplication was performed in 15 mentally handicapped children; 13 also had a feeding gastrostomy. Age varied from 1.5 to almost 17 years (mean 7 years). Mean weight was 18 kg (5-50 kg). All patients underwent an upper GI study and endoscopy as well as pre- and 3 months postoperative pH study. Indications for the procedure were reflux esophagitis in 11 and feeding problems with silent reflux in 4. RESULTS: The laparoscopic procedure was converted in the second patient because of bleeding in the hiatus. No further procedure-related intra- or postoperative complications occurred. The mean hospitalization was 3.7 days. No symptomatic postoperative gastroesophageal reflux has been observed. All children have undergone postoperative pH studies, which displayed silent reflux in two. Gastrostomy feeding is well tolerated. CONCLUSION: We conclude that Thal fundoplication can be performed laparoscopically in mentally retarded children. The laparoscopic results are comparable to the open Thal procedure.

Aged↗

Duhamel-Martin procedure for Hirschsprung's disease in neonates and infants: one-stage operation.

BACKGROUND: A retrospective study was performed to demonstrate that a one-stage Duhamel-Martin procedure is feasible for Hirschsprung's disease, even in neonates and infants. METHODS: In a 2 1/2-year period, 32 children with Hirschsprung's disease were treated according to the method of Duhamel-Martin. In 22 of them the diagnosis had been established within the first 2 months of life. RESULTS: Twenty-nine children did not receive a preliminary enterostomy. In the three neonates who did have a preliminary enterostomy, it was closed during the Duhamel-Martin procedure. In the last 2 years, no enterostomies have been performed. CONCLUSION: The one-stage Duhamel-Martin procedure is now feasible in almost all children, irrespective of age and weight.

Anastomosis, Surgical↗