PubMed Health⌕ Search

Biomedical subjects

D Călugăru

Publications and source records attributed to D Călugăru.

10 recordsLinked to original sources
PubMed2006

[Does the ocular hypertension need treatment].

The authors review the risk factors that influence conversion of ocular hypertension into primary open-angle glaucoma. They are represented mainly by advanced age and higher intraocular pressure, central corneal thickness as well as greater values of vertical and horizontal cup/disc ratios. Therapy must be immediately performed if there is a moderate or high conversion risk (e.g. elderly age, greater intraocular pressure, central corneal thinnness, greater cup/disc ratio) (10% of cases). Should these factors be missing (more than 90% of the patients) then the treatment is not necessary, the only thing that has to be done is thorough monitoring of these patients.

Antihypertensive Agents↗
PubMed2006

[Optic nerve disc drusen].

Optic nerve head drusen represents a frequent condition, with unknown pathogenesis, mostly asymptomatic. Here, we present a patient with visual impairment, who has reacted well to anti-inflammatory and vasodilator treatment.

Anti-Inflammatory Agents↗
PubMed2006

[Choroidal hemangioma and epiretinal membrane].

Choroidal hemangiomas are benign vascular hamartomas developed from birth, but undetected until the 4th and 5th decade. They have been seldom described in association with epiretinal membranes. Here we present a patient with associated pathology choroidal hemangioma with atypical fluorescein angiography pattern, undetected on ocular echography hence the difficulties in establishing a positive diagnosis and epiretinal membrane observed both clinically and on fluorescein angiography. Visual acuity is impaired by cystoid macular edema, with a complicated pathogenetic mechanism.

Choroid Neoplasms↗
PubMed2004

[Timolol topical ophthalmic combination].

The primary standard therapy in patients with open-angle glaucoma and ocular hypertension is carried out by means of monotherapy with synthetic prostaglandin analogues. Most of the glaucoma patients need more than one medication for adequate intraocular pressure control. Timolol represents the basic component of these combinations. Timolol topical ophthalmic combinations with dorzolamide (Cosopt), pilocarpine, latanoprost (Xalacom), travoprost and unoprostone are thoroughly described. Most antiglaucoma medications achieve on one side directly baroprotection by decreasing intraocular pressure and on the other side they produce indirectly vasoprotection, that is secondary to intraocular pressure lowering. The Cosopt, due to its Dorzolamide component, makes an exception since it produces directly both baroprotection by aqueous humor flow suppression and vasoprotection by increasing the blood flow within the retina, choroid, optic nerve head and retrobulbar area. Given these considerations as well as the fact that the ocular hypotensive effect of both the Cosopt and the latanoprost are equally potent, a question seems reasonable according to accepted standard i.e. Cosopt or latanoprost as primary glaucoma therapy?

Administration, Topical↗
PubMed2004

[Presumed ocular histoplasmosis syndrome].

Presumed ocular histoplasmosis syndrome is a macular hemorrhagic choroiditis of the young adult. The etiology of this syndrome is uncertain, but can be correlated with some positive reactions to histoplasmosis. The study was carried out on 12 patients, each of them was investigated by functional and objective ocular examinations, laboratory tests, fluorescein angiography and ultrasound examinations. The clinical signs of this syndrome of presumed ocular histoplasmosis were: macular focal lesions, subretinian hemorrhages, detachment of the retinal neurosensorial layer, presence of disseminated choroiditis scars and subretinian neovascularization. The correct evaluation of the choriocapillary perfusion is helpful to institute a proper therapy.

Adult↗
PubMed2004

[Latanoprost topical ophthalmic combinations].

Latanoprost became the first line therapeutic agent in glaucoma treatment being the best sold worldwide anti-glaucoma medication. When adequate intraocular pressure decrease can not be achieved with latanoprost monotherapy, then its combinations are to be used. Latanoprost combinations are grouped in to non-fixed and fixed variants. Non-fixed combinations mean concomitant therapy,that is giving the two or more medications using different bottles. The medications used for latanoprost non-fixed combinations are represented by timolol 0.5%, pilocarpine 2%, acetazolamide dispensed systemically and locally, dipivefrin 0.1%, unoprostone 0.12% and brimonidine 0.2%. Fixed combinations mean administering the two mixed medications using one single bottle. At the present time there is only one fixed combination of latanoprost i.e. its combination with timolol 0.5% whose trading name is Xalcom.

Acetazolamide↗
PubMed2001

[Prevalence of glaucoma suspect in patients with central vein occlusion].

PURPOSE: To prospectively study in a 10 year follow-up period the dynamics of the prevalence of the glaucoma suspect in patients with central retinal vein occlusion. METHODS: The study group consisted of 147 patients without diabetes who sustained a unilateral occlusion of the central retinal vein not treated by pan-retinal photocoagulation. As control group 100 age-matched patients belonging to the general population without central retinal vein occlusion and diabetes were used. RESULTS: From an initial frequency of 10.8% the prevalence of the glaucoma suspect had a progressive elevation that hit the highest value of 20.4% in the 5 month following the onset of the occlusion. The decrease of the prevalence down to 4.7% by the end of the follow-up period was accounted for by the fact that in 9 cases a neovascular glaucoma occurred, in 6 cases the central retinal vein occlusion accompanied by glaucoma suspect developed toward an occlusion with normal intraocular pressure and in 8 patients the glaucoma suspect converted into a primary open-angle glaucoma. The prevalence of the glaucoma suspect in patients of the control group was low, ranging between 1 and 4%. CONCLUSIONS: The central retinal vein occlusion influences the onset as well as the development of glaucoma suspect. Glaucoma suspect associated with the central retinal vein occlusion represents a risk factor for the occurrence of both the neovascular glaucoma and the primary open angle glaucoma.

Aged↗
PubMed2000

[The hierarchization of the prognostic factors in uveal malignant melanoma].

PURPOSE: To retrospectively study the prognostical factors, that influence disease development as well as survival in patients suffering of uveal malignant melanoma. METHODS: 100 cases of uveal malignant melanoma were thoroughly reviewed clinically and histopathologically. The analysis of the results were carried out by means of the statistically correlated methods. RESULTS: Factors having a negative prognostical influence upon the patient's survival were classified following their importance, the most significant of them being the histopathologically necrotic cellular type. CONCLUSIONS: Classifying the prognostically negative factors in patients with uveal malignant melanoma enabled to choose the most important of them in order to draw up a clinical record card suitable for ensuring a patient, whose eye had been enucleated due to an uveal malignant melanoma.

Female↗
PubMed2000

[A survival analysis of patients with malignant uveal melanoma].

PURPOSE: Survival rate estimate in patients with uveal malignant melanoma. METHODS: 100 cases of uveal malignant melanoma were retrospectively reviewed clinically and histopathologically. Survival rate assessment of the patients was carried out by means of uni and multivariate analysis. Univariate evaluation was performed using the Kaplan-Meier's method and multivariate analysis by means of the proportional hazards model of Cox. RESULTS: Univariate analysis disclosed some significant factors predicting survival rates such as: the period of time elapsed between occurring the first disease symptoms and the objective appearance of uveal melanoma, personal history connected with melanoma, the size, shape and extrascleral extension of the tumor, the Callender's cell type, the reticulin and melanin amount existing within the tumor, the necrosis extension into the tumor and development or not of the metastases. Multivariate analysis succeeded in disclosing a hierarchy of factors predicting survival rates headed by the histopathologically necrosis cell type. CONCLUSIONS: There are not significant differences between sexes, different age groups and professions with regard to survival rates of the patients with uveal malignant melanoma. Multivariate analysis represents the main means of assessment of the part played by a combination of different prognostical factors in survival of uveal malignant melanoma patients.

Age Distribution↗