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Biomedical subjects

D Cannata

Publications and source records attributed to D Cannata.

81 records · Page 5Linked to original sources
PubMedDate not supplied

[Sudden cardiac death in subjects with healthy heart. Role of heart-mind interactions].

The Authors report the significant progress that has been made in the past few decades in defining the connections between the central nervous system and the cardiovascular system and the mechanisms by which neuroadrenergic influences over cardiac function can lead to heart disease. Moreover, the question of sudden cardiac death, particularly in individuals without a prior history of clinical heart disease, is analysed in the light of present knowledge concerning the deleterious effects on cardiac electrophysiologic properties of psychosocial and behavioural factors.

Arrhythmias, Cardiac↗
PubMedDate not supplied

Combination therapy with subcutaneous interleukin-2 and interferon-alpha in advanced renal cancer patients with poor prognostic factors.

Sixteen patients with metastatic renal cell carcinoma were treated with a combination of low-dose subcutaneous interleukin-2 (IL-2) and recombinant interferon (IFN)-alpha. One treatment course included 6 weeks of treatment followed by a 2-week rest. Patients received therapy as outpatients. All patients were assessable for toxicity and response assessment. Nine patients experienced severe toxicities resulting in dosage modification. The major treatment-limiting side effects were gastrointestinal, cutaneous, fever and flu-like symptoms. One patient (6%) had partial remission and six patients (37.5%) had disease stabilization. Overall median survival was 8 months. In our study IL-2 and IFN-alpha showed a low activity and a quite high toxicity. It seems that the prognostic factors per se rather than treatment options might impact the treatment results in advanced renal cancer patients.

Adult↗
PubMedDate not supplied

Somatuline (BIM 23014) and tamoxifen treatment of postmenopausal breast cancer patients: clinical activity and effect on insulin-like growth factor-I (IGF-I) levels.

Somatostatin analogues have been shown to suppress some hormones and growth factors involved in breast tumour growth and a direct in vivo and clinical antimumour effect has recently been reported. In our study the effects of tamoxifen, combined with a depot somatostatin analogue in 33 postmenopausal untreated breast cancer patients, have been evaluated. Blood samples were obtained before treatment, after 14 days and then monthly, in order to evaluate the behaviour of serum IGF-I, GH and somatuline levels. The drug combination resulted in a significant and synergistic reduction of plasma IGF-I concentration. No significant changes of serum GH were observed. 12.5% of patients exhibited a complete response and 37.5% a partial response for an overall objective response rate of 50% (95% CL 35-69%). The high remission rate reported, the absence of overlapping side effects between tamoxifen and somatuline and the synergistic activity on IGF-I suppression justify a further evaluation of the drug-combination.

Aged↗
PubMedDate not supplied

[Doppler evaluation of diastolic function in hypertrophic cardiomyopathy].

Diastolic function may play a significant role in patients affected by hypertrophic cardiomyopathy, because abnormalities in diastolic function, even in presence of a normal systolic function, may determine the clinical features of the disease. Doppler ecocardiography, using a non-invasive and not highly expensive method, easily allows to analize the indexes of diastolic function, as soon as some morpho-functional parameters, represented by extent and localization of the myocardial hypertrophy and presence or absence of obstruction in the left ventricular outflow, which have always been considered relevant in the prognosis together with the typical arrhythmic abnormalities of the disease. The aim of this study was to investigate the behaviour of Doppler ecocardiographic parameters of diastolic function in 38 patients with hypertrophic cardiomyopathy and to analize whether they might be correlated with the morpho-functional patterns and clinical features of the disease, represented by the NYHA functional class and occurrence of ventricular tachycardia during 48 hour ambulatory electrocardiographic monitoring. Diastolic function abnormalities, although occurring in most patients, do not seem to be related with clinical conditions and/or with the typical morpho-functional patterns of the disease; however, an increase in the left atrial size together with a specific increase in the rate of deceleration of flow velocity in early diastole that were detected in patients with ventricular tachycardia, by suggesting a relation between diastolic dysfunction and arrhythmogenic substrate, remarks the importance of the analysis of diastolic function for a better prognostic evaluation of the hypertrophic cardiomyopathy.

Adolescent↗