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Biomedical subjects

D Carles

Publications and source records attributed to D Carles.

68 records · Page 4Linked to original sources
PubMed1983

[Primary carcinoid of the larynx].

Primary carcinoid of the larynx is an extremely rare neoplasm. Only seven cases could be traced in the literature so far. The authors report another case in a 71 year-old male patient. Gross examination revealed a large ulcerated tumor of the right part of the supraglottic larynx. Microscopically, the tumor was composed of nests and sheets of relatively uniform cells with round nuclei. A Grimelius stain showed positively stained granules in the cytoplasm of the cells. One cervical lymph node presented little metastatic foci of the tumor cells. A review of the medical literature showed that all laryngeal carcinoid were pathologically malignant and the treatment of choice is the surgical excision.

Aged↗
PubMed1982

[Systematic study of limb anomalies in a population of 35,600 consecutive newborn infants].

During the surveillance of a consecutive sample of 35.600 liveborn infants in an urban hospital, limb anomalies were specially analysed. Polydactyly (28 cases), syndactyly (14 cases) and absence deformities (20 cases) looked not rare. No specific human teratogen have been recognized but this epidemiologic study is still in progress. The effect of chronic exposure to volatile anesthesics in operating rooms is evoked in two ectrodactylies.

Arm↗
PubMed1978

[Organ culture of human skin using dermis from cadavers].

An original method for organ culture of human skin epithelial cells using as a support human skin grafts obtained from the Human tissue Band of "C.H.R. de Bordeaux" is described. Methods and results of this technic which seems to represent a forward step relative to traditional practices are exposed.

Cadaver↗
PubMedDate not supplied

Contribution of transvaginal ultrasonography and fetal cerebral MRI in a case of congenital cytomegalovirus infection.

Cytomegalovirus is the most common cause of congenital viral infection. In utero this infection is usually suspected on the basis of ultrasound findings. We present a case in which routine ultrasound examination demonstrated a decrease in fetal cephalic dimensions at 32 weeks' gestation in an asymptomatic patient. Transvaginal ultrasound revealed echogenic vessels in the thalami and lesions in the subependymal region. Suspected diagnosis of fetal cytomegalovirus infection was confirmed by positive titers of anti-cytomegalovirus-IgM antibodies in fetal blood and amniotic-fluid PCR studies. Fetal cerebral MRI demonstrated parenchymal atrophy and polymicrogyria. The parents decided to terminate the pregnancy, and necropsy confirmed the diagnosis. Suspicion of CMV fetal infection should prompt transvaginal ultrasound and fetal brain MRI.

Adult↗
PubMedDate not supplied

Prenatal diagnosis of schizencephaly by fetal magnetic resonance imaging.

Schizencephaly is a neuronal migration anomaly characterized by gray matter lined clefts extending from the ventricle to the cortical surface leading to specific lesions, well demonstrated by imaging. The lips of the clefts can be fused or separated. Prognosis is related to the extend of the involved cortex. Both genetic and acquired factors can be responsible for this pathology. Three cases of antenatal diagnosed open schizencephaly are reported. Two cases are unilateral and one is bilateral. A cerebral anomaly has been detected in all cases by routine ultrasonography (US) revealing a ventricular dilatation with cortical associated abnormalities. Prenatal magnetic resonance imaging (MRI) permitted the diagnosis in the 3 cases. All cases had led to abortion because of the importance of the cortical defect. The aim of this report is to point out the importance of fetal MRI in the diagnosis of migration disorder and to discuss the medical implications. Indeed, MRI is better suited than US for the prenatal diagnosis of schizencephaly, being able to detect normal and abnormal brain cellular migration, especially with fast imaging (HASTE sequences). With its multiplanar imaging capability, MRI demonstrates the cleft extending from the pial surface to the ventricular ependyma and thus provides characteristic diagnosis of this disorder. Moreover, ventricular dilatation, a frequent anomaly detected by US should be completed with MRI in order to research a neuronal migration disorder.

Brain↗
PubMedDate not supplied

[Anatomo-pathologic diagnosis of neonatal malformations of the urinary tract. 1: Malformations of the kidney parenchyma].

Congenital anomalies of the urinary tract are of great pathological importance and account for about 10,9 per cent of all fetal and neonatal autopsies. This paper reports 17 cases of such lesions compiled from 156 consecutive autopsies of newborn infants performed during 33 months at C.H.R. de Bordeaux (France). Each malformation is discussed, using embryological classification. These lesions can occur independently but usually they are associated with other organ abnormalities. Whenever, an hereditary syndrome must be seek after. In a first part, we present the anomalies of the kidney proper. In a second part, we shall present the anomalies of the excretory apparatus, bladder and urethra.

Abnormalities, Multiple↗
PubMedDate not supplied

[Anatomo-pathological diagnosis of neonatal malformations of the urinary tract. II. Excreto-urinary tract malformations].

Congenital anomalies of the urinary tract are of great pathological importance and account for about 10.9 per cent of all fetal and neonatal autopsies. This paper reports 17 cases of such lesions compiled from 156 consecutive autopsies of newborn infants performed during 33 months at C.H.R. de Bordeaux. Each malformation is discussed, using embryological classification. These lesions can occur independently but usually they are associated with other organ abnormalities. Whenever, an hereditary syndrome must be seek after. In a first part, we have presented the anomalies of the kidney proper. In a second part, we shall present the anomalies of the excretory apparatus, bladder, and urethra.

Abnormalities, Multiple↗
PubMedDate not supplied

Diprosopia revisited in light of the recognized role of neural crest cells in facial development.

OBJECTIVE: The aim of this study is to compare the theory of embryogenesis of the face with human diprosopia. This peculiar form of conjoined twinning is of great interest because 1) only the facial structures are duplicated and 2) almost all cases have a rather monomorphic pattern. The hypothesis is that an initial duplication of the notochord leads to two neural plates and subsequently duplicated neural crests. In those conditions, derivatives of the neural crests will be partially or totally duplicated; therefore, in diprosopia, the duplicated facial structures would be considered to be neural crest derivatives. If these structures are identical to those that are experimentally demonstrated to be neural crest derivatives in animals, these findings are an argument to apply this theory of facial embryogenesis in man. METHODS: Serial horizontal sections of the face of two diprosopic fetuses (11 and 21 weeks gestation) were studied macro- and microscopically to determine the external and internal structures that are duplicated. Complete postmortem examination was performed in search for additional malformations. RESULTS: The face of both fetuses showed a very similar morphologic pattern with duplication of ocular, nasal, and buccal structures. The nasal fossae and the anterior part of the tongue were also duplicated, albeit the posterior part and the pharyngolaryngeal structures were unique. Additional facial clefts were present in both fetuses. Extrafacial anomalies were represented by a craniorachischisis, two fused vertebral columns and, in the older fetus, by a complex cardiac malformation morphologically identical to malformations induced by removal or grafting of additional cardiac neural crest cells in animals. CONCLUSION: These pathological findings could identify the facial structures that are neural crest derivatives in man. They are similar to those experimentally demonstrated to be neural crest derivatives in animals. In this respect, diprosopia could be considered as the end of a spectrum, whereas the other end is agnathia-holoprosencephaly complex. This assumption has to be discussed, but we want to draw attention to the fact that diprosopia must not be considered as a curious form of conjoined twinning, but as a major means of bringing us a better knowledge of the facial embryogenesis in man.

Abnormalities, Multiple↗
PubMedDate not supplied

Meconium ileus and intestinal atresia in fetuses and neonates.

A collaborative study was performed to determine the different types and mechanisms of intestinal abnormalities during gestation. Cases had to fulfill one or more of the following three criteria: (1) meconium ileus, (2) intestinal stenosis or atresia, and (3) meconium peritonitis. Esophageal atresia, anorectal atresia, and abdominal wall defects were excluded. One hundred two cases were reviewed from the autopsies of 42 induced abortions, 22 stillborns, and the surgical findings in 38 neonates. Meconium ileus was detected mainly during the second trimester (28/38), and was associated with cystic fibrosis (15), fetal blood deglutition (4), infection (6), or multiple-abnormalities (10), in which three chromosomal aberrations were found. Intestinal stenosis or atresia was more commonly detected during the third trimester of gestation (46/56). Sixteen of the 30 duodenal malformations were associated with trisomy 21, whereas in the 26 small intestinal atresias, signs of distress or ischemia were most frequently detected. Only 8 of 25 meconium peritonitis cases were isolated. A total of 20 cystic fibrosis cases could be proved. In this series, functional abnormalities were observed predominantly in the second trimester and associated mainly with cystic fibrosis or amniotic fluid abnormalities. Anatomic lesions were commonly detected later on and associated with ischemic conditions, chromosomal aberrations, and even cystic fibrosis.

Constriction, Pathologic↗