The separation of rabbit anti-dinitrophenyl IgG antibodies on the basis of combining site depth.
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Animals↗
Biomedical subjects
D Carson
Publications and source records attributed to D Carson.
Immunochemical analysis of the cross-reacting idiotypes of mouse myeloma proteins with anti-dextran activity and normal anti-dextran antibody.
The idiotype of the mouse myeloma protein with anti-alpha-1,3 dextran activity, J558, has been characterized by a solid-phase radioimmunoassay. The idiotype of the J558 protein depends on a specific light and heavy chain interaction and is altered in the presence of the hapten, nigerose. Cross-reacting idiotypes were found on another mouse myeloma protein with alpha1,3 dextran specificity, normal anti-dextran antibody, and certain reconstructed myeloma proteins composed of the J558 heavy chain and heterologous light chains.
Amino Acid Sequence↗
Intracranial EEG monitoring in Landau-Kleffner syndrome associated with left temporal lobe astrocytoma.
A 3 1/2-year-old boy developed partial complex seizures with right-sided motor activity, occasionally secondarily generalized at age 18 months. Initial EEG showed left-sided focal epileptiform discharges. Seizures became refractory to antiepileptic drugs (AEDs). At age 3 years, there was severe language deterioration consistent with Landau-Kleffner syndrome (LKS). At that time, an EEG showed almost continual generalized spikes and polyspikes, worse during sleep. Video-EEG showed generalized tonic seizures associated with generalized EEG ictal activity. Magnetic resonance imaging (MRI) showed a cystic and solid lesion of the left hippocampal and parahippocampal gyri without surrounding edema. Subdural strip electrodes under the left temporal and overlying the left frontal lobes demonstrated interictal spikes simultaneously in all recording contacts. Ictal EEG activity occurred in the temporal electrodes 0.2-1 s before appearing in the frontal electrodes. After left temporal lobectomy with subtotal resection of a low-grade astrocytoma, he had an immediate marked decrease in seizures. In 1 month he was seizure-free, and in 6 months had no further seizures and markedly improved language. These findings provide further evidence that left temporal structural epileptogenic lesions may contribute significantly to the pathophysiology of LKS.
Aphasia↗
Evaluation of Ames DCA 2000 for the rapid measurement of HbA1c in an outpatient clinic.
Comparison of the Ames DCA 2000, a new device for the rapid measurement of HbA1c, with the established laboratory method (Dako HbA1c system) was made in 58 children routinely attending a diabetic outpatient clinic. Results showed that DCA 2000 and laboratory estimations of HbA1c were closely correlated throughout the range of values (R = 0.95). The mean difference between values was 1.83% with a 95% range of agreement of 0.23-3.4%. The DCA 2000 can be used to provide a rapid estimate of HbA1c upon which decisions on changes in treatment can be based at diabetic clinics.
Child↗