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Biomedical subjects

D Celener

Publications and source records attributed to D Celener.

35 records · Page 2Linked to original sources
PubMed1986

Effects of sex and age on pancreatic secretion.

The secretory response of the exocrine pancreas to an intravenous bolus of secretin (1.0 U/kg) was studied in healthy men and women below and above 45 years of age. We studied the secretory pattern, i.e., electrolyte and enzyme secretion in 8 sequential, 10-min collections and cumulative values for each parameter. Within the male group, no significant changes were observed, except for higher amylase and lipase secretions in the older subjects. On the other hand, females over 45 yr old had secretory patterns that showed a decline of flow and of bicarbonate concentration and output. No significant secretory differences were observed in the groups of younger males and females. When the over-45 groups of men and women were compared, the women exhibited a significant decrease in bicarbonate concentration and output. Moreover, this group of women had a cumulative 80-min output of bicarbonate and lipase significantly below these parameters in the men. Possible mechanisms are discussed.

Adult↗
PubMed1984

Action of amiodarone over the extension and reversibility of experimental myocardial infarction in pigs.

The purpose of the present work is to evaluate the action of a benzofuran derivative, Amiodarone, on an experimental acute infarction model. Six pigs were intravenously administered 1 mg/kg Amiodarone (A) 20 minutes before inducing ischemia (I) by occlusion of the anterior descending coronary artery, which was maintained for 90 minutes. A similar dose level was repeated 20 minutes before ligation release (R). Similarly, another six animals received a placebo and formed the Control Group (C). The extent of myocardial injury was assessed by summations of ST segments (Sigma ST) and R (Sigma R) and Q (Sigma Q) waves of electrocardiographic epicardial mappings, as well as by serum levels for SGOT and LDH. Systemic blood pressure, pulmonary pressure, right atrial pressure, systemic resistance and cardiac output were also controlled. Two hundred and ten minutes after R, the animal was sacrificed for the purpose of carrying out morphological and histochemical studies. No significant differences were observed in the blood pressure of either group. During I, systemic resistance values suffered a drop in the Amiodarone Group A, whereas they increased in both groups after reperfusion. Pulmonary pressure was higher in Group A. Cardiac output showed a similar behavior in both groups up to R, when it significantly decreased in animals receiving Amiodarone. The Sigma ST and the Sigma Q were higher in the Control Group C, whereas the Sigma R was higher in Group A. The SGOT and LDH levels were higher during R in Group C. Histochemistry showed a higher activity for SDH and LDH in treated animals. Due to its action on afterload, its contractility and its direct myocardial action, Amiodarone limited the extent of necrosis and increased the recoverable amount of myocardium.

Journal Article↗
PubMed1981

[Trophic and functional changes of the pancreas induced by chronic truncal vagotomy].

The effects of chronic truncal vagotomy on the pancreatic gland was studied in male adult Wistar rats. Two to three months after parasympathetic decentralization, the gland weight was found to be significantly increased by nearly 100%. This trophic effect is mainly due to the proliferation of young acinar cells. Concomitantly, there is a decrease of the ductular mass and of the Langerhans islets. Choline acetylase activity was decreased by about 35% to 40% in the vagotomized pancreas. Further, enzyme concentration was found to be greater in the head than in the body and tail of the gland, thus suggesting a higher nerve density of vagal cholinergic fibers in the former than in the latter. Basal pancreatic secretion of the decentralized gland showed a significant increase in the flow rate with no significant changes in both bicarbonate concentration and output. Protein concentration was significantly reduced at 60 minutes; protein output remained unchanged. The most remarkable finding was the fall in both lipase concentration and output (60-70%) when compared with control values. These findings may be related to clinical manifestations after long-term vagotomy.

Animals↗
PubMed1978

Chronic nonspecific duodenitis (bulbitis).

"Bulbitis" was classified by fiberoptic endoscopy in: superficial, erosive and pseudopolypoid. Endoscopic diagnosis of "bulbitis" is reliable, as good agreement was obtained in 100 cases tabulated according to histological grading. Erosive "bulbitis" implies a severe histopathological compromise.

Duodenal Diseases↗
PubMed1978

Does secretin influence rat colonic absorption and secretion?

In rats, a secretin (Jorpes) intravenous infusion superimposed on an intracolonic sodium acetate perfusion elicits, with respect to control values, a significant depression of Na+ absorption (0.16 mEq./h-0.00 mEq./h.) and mucus secretion (230-40 mg.). When the hormone is superimposed upon an intracolonic infusion of acetic acid, mucus secretion is also significantly inhibited (790-340 mg.). The influence of secretin on organic anion movement was pH related. At pH values of 7.0, absorption was unchanged (0.34--0.33 mEq./h.), at pH values of 2.9, absorption was significantly reduced (0.67-0.41 mEq./h). The secretin impairment of colonic mucus secretion could influence the transport of watersoluble (Na+) and lipid soluble (acetic acid) substances, probably through changes at the "unstirred layer" level.

Acetates↗
PubMed1977

Histochemical study of cholinergic activities in exocrine pancreas of dogs. Modifications related to chronic alcoholism.

An histochemical study has been made of pancreatic biopsies from 5 dogs with gastric and pancreatic Thomas cannulae. 3 dogs received 2 g kg-1 day-1 ethanol for 3, 4 and 48 months; 2 dogs which did not received alcohol served as controls. Acetylcholinesterase has been studied by the histochemical method of Koelle. Choline acetyl transferase by the method of Burt. Our results suggest that there is less acetylcholinesterase activity in the pancreas of alcoholic dogs than in control dogs. This is as more pronounced when the alcohol consumption is prolonged. On the contrary, the intensity of the histochemical reaction for choline acetyl transferase is greater in alcoholic dogs than in controls. Although histochemical methods are only semi-quantitative, these results suggest that the cholinergic tone of the exocrine pancreas is increased in chronic alcoholic dogs. This has already been suggested by previous physiological experiments performed on the same animals.

Acetylcholinesterase↗