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Biomedical subjects

D Chance

Publications and source records attributed to D Chance.

3 recordsLinked to original sources

An opinion survey of reported benefits from the use of stereolithographic models.

PURPOSE: The aim of the study was to determine the possible benefits from 3-dimensional epoxy stereolithographic (SL) models produced from computed tomography (CT) and magnetic resonance imaging (MRI) data. MATERIALS AND METHODS: Surgeon's opinions about the use of SL models for diagnosis, treatment planning, practicing surgery preoperatively, within the operating room during surgical procedures, and for the construction of custom titanium implants or surgical devices were tabulated, using a 2-page survey. RESULTS: Most of the surgeons found SL models useful in all phases of planning and implementation of surgical procedures. Sixty-five percent found that exposure to the SL model changed the way in which they approached the patient's surgery. They also determined that there was a median timesavings of 20% in expended operating room and anesthesia time. Sixty-two percent of surgeons believed the models were important for proper diagnosis. CONCLUSIONS: Most surgeons using 3-dimensional epoxy SL models for surgical procedures found them beneficial for diagnosis, treatment planning, as a reference during surgery, and in the fabrication of custom implants and surgical devices that afforded surgical solutions previously not available. Patients were believed to have received better care, because the surgeons had more knowledge of their unique anatomy before surgery. Through the use of these models, the patients experienced shorter surgical procedures, with more predictable results.

Attitude of Health Personnel↗

Effect of combinations of acyclovir with vidarabine or its 5'-monophosphate on herpes simplex viruses in cell culture and in mice.

The combination of various concentrations of acyclovir and vidarabine or its 5'-monophosphate usually produced an additive interaction with various strains of herpes simplex virus types 1 and 2 in Vero cells. Similarly, certain combinations of these drugs were more effective than the individual drugs in decreasing the mortality and increasing the mean day of death of mice inoculated intracerebrally with herpes simplex virus type 2. Neither antagonism nor interference was noted for any of the in vitro or in vivo combinations. The increased antiviral activity was determined not to be secondary to toxic effects of the drugs. Although viruses resistant to either vidarabine or acyclovir developed readily in cell culture, no evidence of cross-resistance was obtained. Furthermore, in the presence of the two drugs, mutants resistant to vidarabine, acyclovir, or vidarabine/acyclovir could not be isolated. These findings suggest that combinations with these antivirals, which are currently being evaluated singly for the therapy of severe forms of herpetic infection, could prove clinically useful if increasing numbers of resistant viral strains are observed.

Acyclovir↗