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Biomedical subjects

D Chandanayingyong

Publications and source records attributed to D Chandanayingyong.

14 recordsLinked to original sources
PubMed1990

Massive chemotherapy and autologous bone marrow transplantation in Burkitt's lymphoma: the first two patients successfully treated in Thailand.

Massive chemotherapy and autologous bone marrow transplantation (ABMT) have been successfully used for the treatment of Burkitt's lymphoma. We report our first success with such treatment in two children with Burkitt's lymphoma in Thailand. Both patients had massive abdominal tumors with ascites and minimal bone marrow metastasis at the first presentation. They received induction chemotherapy and intensive treatment including central nervous system prophylaxis with cranial irradiation and intrathecal methotrexate until being in complete remission before starting massive chemotherapy, comprising the combination of BCNU, cytosine arabinoside, cyclophosphamide and 6-thioguanine followed by ABMT. Both patients recovered completely following intensive supportive treatments post ABMT and are still good health without evidence of the disease for 18 and 8 months after transplantation respectively. The role of massive chemotherapy and ABMT for the treatment of non-Hodgkin's lymphoma especially Burkitt's lymphoma was discussed.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1979

Further study of Rh, Kell, Duffy, P, MN, Lewis and Gerbiech blood groups of the Thais.

Blood and saliva from unselected blood donors at the Blood Bank, Siriraj Hospital were studied. Two Kell positive, two Rh negative and one Gerbiech negative were found, which could be considered as rare blood type in Thailand. The commonest Rh gene complex was CDe (R11 and the presence of CDE (Rz) in this study are the usual pattern of people in Southeast Asia. Fya is very common as in other people of Asia. In the Lewis system, the incidence of Le (a + b -) was 28.48% which agree well with our previous report 30.9%. There were 410 out of 1,668, (23.17%) who were found to be Lea non-secretor and 95 of them have Lewis antibodies in their sera. Aberrant secretion patterns were also found in this study, 5 people were found to secrete A or B substances according to their blood groups but no H substance was detectable. Further investigation of Lewis groups and secretion in Thailand are needed.

Blood Donors↗
PubMed1979

Unexpected red cell antibodies in donors and patients at Siriraj Hospital.

The incidence of unexpected red cell antibodies in patients and donors at Siriraj Hospital were found to be 4.91% and 4.33% respectively. Anti Lewis, anti P1 and anti Mia were the most common antibodies detected. Antibodies of Rh system were the next, in which anti E was more common than anti D. Anti Jka, Jkb, Fyb, Dia, S and rare antibodies such as anti K, Ge1, Mta and H were also detected in this study.

Blood Donors↗
PubMed1977

The incidence of HLA antigens in leprosy.

HLA antigens were studied in 36 patients, with leprosy, 20 cases of lepromatous and 16 cases of tuberculoid type. Eleven out of 36 (30.55%) had BW40 as compared to 9.33% of 150 controls. The frequency of BW40 in tuberculoid patients (31.25%) was not different from that in lepromatous cases (30%).

Humans↗
PubMed1977

A case of Oh (Bombay) blood found in a Thai-Muslim patient.

This is a report of a case of an inherited Lewis a + b - Oh (Bombay) blood found in a Thai-Muslim patient. The propositus and her brother inherited the suppressant xx (or hh) genes from her parents; the gene frequency could not be surveyed.

Blood Group Antigens↗
PubMed1975

Studies on anti-Mi-a and the MiIII complex.

Some Ms/Ms MiIII red cells react weakly with rabbit anti-N but not with human anti-N sera. Specificities of different anti-Mi-a within the Miltenberger complex have been defined by absorbtion studies with different Mi classes.

Animals↗