PubMed Health⌕ Search

Biomedical subjects

D Chandra

Publications and source records attributed to D Chandra.

At least 55 records · Page 3Linked to original sources
PubMed1986

Age dependent changes in the expression of Drosophila mitochondrial proteins.

A subset of 43 [35S]methionine labeled mitochondrial proteins, identified on two dimensional electrophoresis gels of whole body extracts of adult Drosophila, were compared between two age groups. These flies, which except for their spermatocytes consist entirely of postmitotic cells, were 6 days old and 38 days old, with the mean life span of this inbred strain being 32.5 days. Qualitative changes in any of these mitochondrial polypeptides were not found, but significant quantitative differences were observed. Quantitation of the 43 mitochondrial proteins was carried out by computer assisted microdensitometry of autoradiograms of the gel patterns. The total amount of isotope incorporated into the mitochondrial proteins of the senescent flies decreased to 71% of that of the young insects. This decrease was heterogeneously distributed among the 43 proteins; however, six remained unchanged and one protein (mol. wt = 75; pI = 7.4) was increased 2.4 times in the senescent flies. These data clearly provide evidence that the age-dependent changes in the expression of mitochondrial proteins are quantitative and not qualitative.

Aging↗
PubMed1986

Antagonism of acute feeding response to 2-deoxyglucose and 5-thioglucose by GABA antagonists: the relative role of ventromedial and lateral hypothalamus.

The effect of GABA antagonists picrotoxin and bicuculline was studied on hyperphagia caused by 2-DG and 5-TG. The GABA antagonists were administered either SC or into the VMH or LH through stereotaxically implanted chronic cannulae. The peripheral as well as VMH injection antagonised the hyperphagia significantly. In contrast, injection of these agents into the LH failed to produce any effect. These findings show that in a glucoprivic state there might be an increased GABAergic activity in the VMH.

Animals↗
PubMed1984

Inhibition of insulin hyperphagia by gamma aminobutyric acid antagonists in rats.

The effects of GABA antagonists, picrotoxin and bicuculline were studied on hyperphagia caused by insulin in free feeding rats. It was found that peripheral administration of GABA antagonists inhibited this hyperphagia. These agents were administered in the VMH and LH through stereotaxically implanted cannulae. It was found that the food intake was inhibited when injected into the VMH, but not in the LH. These findings suggest that LH plays a relatively passive role as compared to VMH, where GABA appears to be an important neurotransmitter.

Animals↗
PubMed1970

A clinical and epidemiological study of an epidemic of febrile illness with haemorrhagic manifestations which occurred at Kanpur, India, in 1968.

An epidemic of febrile illness associated with haemorrhagic manifestations and shock occurred at Kanpur, India, during 1968. The epidemic was widespread in the city, involving about one-tenth of the population; cases were more frequent in thickly populated localities with poor sanitary conditions. Those affected were mainly adolescents and adults of both sexes and multiple cases occurred in families. The disease was characterized by the sudden onset of fever, associated with severe headache and low backache. A number of patients had bradycardia, vomiting and diarrhoea and macular skin rashes associated with itching. A small percentage of the patients had haemorrhagic manifestations in the form of haematemesis, haemoptysis, melaena, haematuria and bleeding per vaginum. The mortality was very low. Dengue type 4 virus has been implicated in the epidemic.

Adolescent↗