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Biomedical subjects

D Chaouat

Publications and source records attributed to D Chaouat.

53 records · Page 3Linked to original sources
PubMed1980

[Pathogenesis of polymyositis (author's transl)].

There are few convincing arguments for a direct intervention of humoral immunity mediated by specific antibodies or circulating immune complexes. Arguments in favour of a cytotoxic reaction are stronger. The likelihood of an infectious origin is supported by the presence of cell inclusions resembling myxovirus or picorna virus of the coxsackie group, and toxoplasmas may also be involved. The high incidence of associated cancers has given rise to speculations on the relationship between the two diseases, such as: myotoxic substances secreted by malignant tumours, delayed hypersensitivity reaction to a common antigen, or different effects of a single hypothetic causal agent.

Animals↗
PubMed1980

[Giant cell thromboangiitis in a patient taking an oral contraceptive (author's transl)].

Pathological examination in a patient who developed an ischemic cerebrovascular accident while taking an oral contraceptive demonstrated widespread lesions in the right and left carotid regions. Histological examination revealed the presence of an obliterating thromboangiitis in the arterial walls, with subendothelial fibrosis of the intima, arterial thrombosis, and a marked giant cell reaction where the lesions were in contact with the internal elastic layer. Immunological and biological anomalies confirmed the inflammatory nature of the lesion with the presence of anti-ethinyl estradiol antibodies in the serum and circulating blood immune complexes. These biological and histological results suggest the immunological nature of the mechanism of origin of the cerebrovascular accident in this case.

Adult↗
PubMed1978

[Reflex algodystrophy of the lower limbs during pregnancy].

Four cases of neurotrophic rheumatism during the course of pregnancy are reported. Observations in 9 cases from the literature allowed the isolation of the principal features of this sort of algodystrophy. It occurs in the last trimester of pregnancy, attacking usually and almost exclusively the lower limbs, especially the left hip. There is rapid resolution after delivery, occasionally preceded by a rebound in the post-partum period. Responsability of pregnancy as the cause of the neurotrophic rheumatism is not in much doubt. It apparently arises from a shift of mechanical factors linked with the uterine enlargement which without doubt causes pressure of the pelvic sympathetics.

Adult↗
PubMedDate not supplied

Dropped head syndrome. Three case-reports.

Dropped head syndrome is characterized by gradual forward sagging of the head due to weakness of the neck extensor muscles. We report three cases in elderly patients seen by rheumatologists at our institution. There was some evidence suggestive of a neurogenic process, whereas most reported cases of dropped head syndrome have been ascribed to myopathy. Dropped head syndrome can probably be produced by multiple causes. The close ties between dropped head syndrome and acquired camptocormia in adults are discussed.

Aged↗
PubMedDate not supplied

[Chronotherapy of tenoxicam].

A study was carried out in order to investigate the chronotherapy (dosing time dependency) of an NSAID, the tenoxicam administered in ankylosing spondylitis, rheumatoid arthritis and osteoarthritis of the hip. These variations in efficacy exist as much for pain as for stiffness and maximum efficacy is obtained with administration at 8 am or 12 pm. Since the tolerance was good, we recommend midday as an optimal once-a-day dosing time.

Adult↗
PubMedDate not supplied

[Idiopathic neuroarthropathy in a woman (author's transl)].

The authors report a case of idiopathic and sporadic neuroarthropathy in a 53 year - old woman and point out the rarety of the disease in women unstead of familial Thevenard disease and diabetic neuroarthropathy.

Acrodermatitis↗
PubMedDate not supplied

[Involvement of the central nervous system in Behçet's syndrome. Report of two cases (author's transl)].

After presenting two personal observations, the authors underline the fact that the neurological manifestations of Behçet's disease are more frequent than they were supposed to be. Their symptoms are overly manifold but have in common constant abnormality in the cerebrospinal fluid when an attack occurs. The affection is a very serious one demanding an early and well established diagnosis only to be obtained thanks to a clinical examination. Corticosteroïd therapy (1 mg/kg per day) either alone or associated with immuno-suppressive therapy may check the attack. Preventing relapses implies a non-stop treatment. Immuno-suppressive therapy seems to be the most efficient one.

Adrenal Cortex Hormones↗
PubMedDate not supplied

[Iatrogenic arthritis after intestinal by-pass as a treatment for obesity (author's transl)].

The authors report three observations of patients having suffered from arthralgias as an aftermath of intestinal by-pass for treatment of refractory obesity. They remind the main troubles cropping up after such surgical treatment and refer to the data already existing in the literature dealing with articular manifestations. They think this pathology is in keeping with arthritis already reported in inflammatory colitis and they suggest a similar pathogeny.

Adult↗
PubMedDate not supplied

[Subacute benign edematous polyarthritis in the elderly].

Subacute edematous polyarthritis of the elderly is a recently described syndrome. The condition is characterized by its sudden onset and by the presence of important edema of the four limbs, symmetrical polyarthritis, marked inflammatory syndrome, and negative serological test for the rheumatoid factor. Men are predominantly affected, and many of them are carrying the HLA B-7 antigen. The illness subsides within a few months without sequelae. It seems that this syndrome should be clearly distinguished from late onset rheumatoid arthritis and polymyalgia rheumatica.

Acute Disease↗