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Biomedical subjects

D Chenoweth

Publications and source records attributed to D Chenoweth.

At least 19 recordsLinked to original sources
PubMed1989

Nafamstat mesilate attenuates pulmonary hypertension in heparin-protamine reactions.

Rapid protamine reversal of heparin anticoagulation in awake sheep caused, after 1 min, a approximately 15-fold increase of arterial plasma thromboxane B2 (TxB2) levels, a 4-fold rise of pulmonary vascular resistance (PVR), a 2-fold rise of pulmonary arterial pressure, and after 3 min, a 2-fold rise of ovine arterial plasma complement C3a levels (P less than 0.05). Infusion of nafamstat mesilate (FUT-175), a protease and complement pathway inhibitor, before protamine reduced these increases by approximately 60-90% (P less than 0.05). FUT-175 did not modify heparin + protamine-induced leukopenia, suggesting that FUT-175 incompletely blocked C5a production. We also learned that infusing protamine first and heparin 5 min later did not increase either plasma C3a or TxB2 levels or PVR while the activated clotting time increased only minimally. Thus, in awake sheep, the sequence of heparin and protamine infusion influences complement activation and pulmonary vasoconstriction. FUT-175 pretreatment reduces thromboxane release and pulmonary vasoconstriction probably by limiting complement activation.

Animals↗
PubMed1989

Nurses' intervention in specific risk factors in high risk employees. An economic appraisal.

1. Occupational health nurses can lower employees' health risks through appropriate screening, education, and monitoring efforts at the worksite. 2. In addition to health promotion as well as benefits education, influencing the demand for health care, creating cost efficient services, and informing employees on how, when, and why to use cost efficient health care services, are the foundations for successful health care cost management. 3. To respond to growing accountability issues, nurses need to quantitatively evaluate the overall impact of their efforts on employees' health status and corporate health care costs. 4. The occupational health nurse can be an effective health care cost manager by using appropriate strategies and resources consistently.

Adult↗
PubMed1988

Identification of the C5a des Arg cochemotaxin. Homology with vitamin D-binding protein (group-specific component globulin).

The chemotactic activity of human C5a des Arg is enhanced significantly by an anionic polypeptide (cochemotaxin) in normal human serum and plasma. The cochemotaxin attaches to sialic acid residues within the oligosaccharide chain of native C5a des Arg to form a complex with potent chemotactic activity for human PMN. We investigated the nature of the cochemotaxin and found that vitamin D-binding protein is the putative cochemotaxin. Vitamin D-binding protein enhanced the chemotactic activity of native C5a des Arg, but had no effect on the chemotactic activity of either native C5a or FMLP. Sialic acid prevented both enhancement by vitamin D-binding protein of the chemotactic activity of native C5a des Arg and formation of C5a des Arg-vitamin D-binding protein complexes, detected by molecular sieve chromatography. Furthermore, vitamin D-binding protein and cochemotaxin exhibited identical molecular weights, isoelectric points, antigenic reactivity, and amino acid composition.

Amino Acids↗